Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations (2020)

Chapter: Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee

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Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Appendix C

Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee

Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Abraham and Baird, 2012 U.S. active-duty service members X Asthma;
COPD;
Pneumonia
Abraham et al., 2012 U.S. service members X Respiratory Symptoms (ICD-9-CM 786);
Asthma;
COPD;
Chronic Bronchitis
Abraham et al., 2014 U.S. service members X AFHSC Respiratory Symptoms (ICD-9-CM 786);
Asthma;
COPD
Baird et al., 2012 U.S./active-duty Army personnel X Respiratory Symptoms (ICD-9-CM 786);
Sinusitis and Rhinitis;
Asthma;
COPD;
Acute Bronchitis (ICD-9CM 460–466)
Banoei et al., 2019 U.S. veterans X X Interstitial Lung Disease (sarcoidosis)
Barth et al., 2014 U.S. veterans X NewGen Sinusitis and Rhinitis;
Asthma;
Chronic Bronchitis		 X
Page 244 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Barth et al., 2016a U.S. veterans X NewGen Sinusitis and Rhinitis;
Asthma;
Chronic Bronchitis		 X
Barth et al., 2016b U.S. veterans X Mortality
Bollinger et al., 2015 U.S. veterans X Mortality
Butzko et al., 2019 U.S. veterans X WRIISC Pulmonary Function Testing X
Davy et al., 2012 Australian Defence Force active-duty personnel X Pulmonary Function Testing;
COPD		 X
DelVecchio et al., 2015 U.S. active-duty Army personnel X Asthma
Díaz Santana et al., 2017 U.S. veterans X NewGen Sleep Apnea
Dion et al., 2013 U.S. Army soldiers X Vocal Cord Dysfunction X
Eick et al., 2011 U.S. active-duty service members X Pneumonia
Falvo et al., 2016a U.S. veterans X WRIISC Pulmonary Function Testing X
Falvo et al., 2016b U.S. veterans X WRIISC Pulmonary Function Testing
Forbes et al., 2019 U.S. active-duty service members X Interstitial Lung Disease (sarcoidosis)
Gwini et al., 2016 Australian veterans X Sleep Apnea;
Asthma		 X
Hines et al., 2013 U.S. veterans X VA Depleted Uranium Surveillance Program Respiratory Symptoms (frequent cough, coughing up phlegm, shortness of breath, wheezing);
Sinusitis and Rhinitis;
Pulmonary Function Testing;
Asthma;
Emphysema		 X
Holley et al., 2016 U.S. service members, National Guard/reserves X Pulmonary Function Testing X
Page 245 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Hooper et al., 2008 U.S. active-duty veterans of Gulf War X Sinusitis and Rhinitis;
Interstitial Lung Disease (sarcoidosis);
Pneumonia
Jani et al., 2017a U.S. service members X AH&OBP Registry/WRIISC Respiratory Symptoms (dyspnea, decreased exercise tolerance) X
Jani et al., 2017b U.S. service members X AH&OBP Registry Constrictive Bronchiolitis X
Khalil et al., 2018 U.S. veterans X Gulf War Era Cohort and Biorepository Respiratory Symptoms (difficulty breathing, shortness of breath, frequent coughing without a cold, wheezing in chest);
Sleep Apnea;
COPD;
Emphysema;
Constrictive Bronchiolitis;
TB;
Cancers
King et al., 2011 U.S. active-duty Army soldiers X Constrictive Bronchiolitis X
Krefft et al., 2017 U.S. veterans X Respiratory Symptoms (cough, chest tightness, wheezing, shortness of breath, decreased exercise tolerance);
Pulmonary Function Testing;
Emphysema;
Constrictive Bronchiolitis;
Interstitial Lung Disease (hypersensitivity pneumonitis)		 X
Krefft et al., 2020 U.S. service members X Pulmonary Function Testing;
Emphysema;
Constrictive Bronchiolitis;
Interstitial Lung Disease (hypersensitivity pneumonitis)		 X
Lindheimer et al., 2019 U.S. veterans X WRIISC Pulmonary Function Testing X
Page 246 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Liu et al., 2016 U.S. service members X AH&OBP Registry Asthma;
COPD;
Emphysema;
Chronic Bronchitis		 X
Madar et al., 2017 U.S. military personnel X X Pulmonary Function Testing;
Constrictive Bronchiolitis;
Interstitial Lung Disease (sarcoidosis, acute eosinophilic pneumonia, pulmonary alveolar proteinosis, idiopathic interstitial pneumonia)		 X
Matthews et al., 2014 U.S. active-duty service members X Pulmonary Function Testing;
COPD;
Emphysema		 X
Maule et al., 2018 Veterans (Australia, Denmark, United Kingdom, United States) X Respiratory Symptoms (coughing, wheezing, shortness of breath);
Sinusitis and Rhinitis;
Asthma
Morris et al., 2014 U.S. active-duty service members X STAMPEDE Respiratory Symptoms (dyspnea, cough, wheeze, sputum production);
Pulmonary Function Testing
Morris et al., 2019 U.S. active-duty Army personnel X STAMPEDE Respiratory Symptoms (dyspnea, cough, wheezing, sputum production, exercise intolerance);
Pulmonary Function Testing		 X
Morris et al., 2020 U.S. service members X STAMPEDE Respiratory Symptoms (exertional dyspnea, cough, wheeze, sputum production, decreased exercise tolerance);
Pulmonary Function Testing;
Constrictive Bronchiolitis		 X
OIF SAPEG, 2003 U.S. active duty military personnel, Reserve/National Guard X Interstitial Lung Disease (acute eosinophilic pneumonia) X
Page 247 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Peacock et al., 1997 U.S. veterans X Comprehensive Clinical Evaluation Program Sleep Apnea
Pugh et al., 2016 U.S. veterans X Asthma;
COPD;
Interstitial Lung Disease		 X
Rivera et al., 2018 U.S. service members, Reserve/National Guard X Millennium Cohort Study Asthma X
Rohrbeck et al., 2016 U.S. active-duty service members X Respiratory Symptoms (ICD-9-CM 786);
Sleep Apnea;
Cancers
Roop et al., 2007 U.S. active-duty Army soldiers X Asthma X
Saers et al., 2017 Swedish military personnel X Respiratory Symptoms (wheeze, wheeze with breathlessness, wheeze without a cold, nocturnal chest tightness, nocturnal breathlessness, nocturnal cough);
Chronic Bronchitis		 X
Sharkey et al., 2015 U.S. service members X AFHSC Respiratory Symptoms (ICD-9-CM 786);
Asthma;
COPD;
Acute Bronchitis		 X
Sharkey et al., 2016 U.S. service members X AFHSC Respiratory Symptoms (ICD-9-CM 786);
Asthma;
COPD		 X
Shorr et al., 2004 U.S. active-duty service members X Interstitial Lung Disease (acute eosinophilic pneumonia) X
Sine et al., 2018 U.S. active-duty service members X Interstitial Lung Disease (acute eosinophilic pneumonia) X
Smith et al., 2008 U.S. active-duty service members X Millennium Cohort Study Sinusitis and Rhinitis;
Sleep Apnea;
Asthma;
Emphysema;
Chronic Bronchitis
Page 248 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Referencea Population 1990–1991 Gulf War Post-9/11 Study Populationb Outcomes Assessedc Smoking Status Collectedd
Smith et al., 2009 U.S. service members, Reserve/National Guard X Millennium Cohort Study Respiratory Symptoms (persistent or recurring cough or shortness of breath);
Asthma;
Emphysema;
Chronic Bronchitis		 X
Smith et al., 2012 U.S. service members X Millennium Cohort Study Respiratory Symptoms (persistent or recurring cough or shortness of breath);
Asthma;
Emphysema;
Chronic Bronchitis		 X
Soltis et al., 2009 U.S. active-duty service members X Acute Bronchitis
Szema et al., 2010 U.S. veterans X Asthma
Szema et al., 2011 U.S. veterans X Pulmonary Function Testing X
Taylor and Ross, 2019 British active-duty service personnel X Respiratory Symptoms (shortness of breath, wheeze, cough);
Sinusitis and Rhinitis
Weinstein et al., 2016 U.S. active-duty service members X Pulmonary Function Testing
Woods et al., 2018 U.S. active-duty Army personnel Asthma X
Zundel et al., 2019 U.S. veterans X Asthma;
Chronic Bronchitis		 X

* “Newly Reviewed” studies are those that have not been addressed in previous National Academies reports.

a Full citations may be found in the References section of Chapter 4.

b Study populations of cohorts that were specified in the Statement of Task are noted.

c Only those outcomes that are addressed in the report are listed. A study may have also addressed other outcomes.

d An “X” indicates that information on smoking was collected, but this does not necessarily mean that it was collected consistently or used in analyses.

NOTE: AFHSC, Armed Forces Health Surveillance Center; AH&OBP, Airborne Hazards and Open Burn Pit; COPD, chronic obstructive pulmonary disease; ICD-9-CM, International Classification of Diseases, 9th edition, Clinical Modification; NewGen, National Health Study for a New Generation of U.S. Veterans; STAMPEDE, Study of Active Duty Military for Pulmonary Disease Related to Environmental Deployment Exposures; TB, tuberculosis; WRIISC, VA War Related Illness and Injury Study Center.

Page 243 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Page 248 Cite Bookmark
Suggested Citation: "Appendix C: Epidemiologic Studies of Respiratory Health Outcomes in Southwest Asia Theater Veterans Newly Reviewed* by the Committee." National Academies of Sciences, Engineering, and Medicine. 2020. Respiratory Health Effects of Airborne Hazards Exposures in the Southwest Asia Theater of Military Operations. Washington, DC: The National Academies Press. doi: 10.17226/25837.
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Next Chapter: Appendix D: Committee Member and Staff Biographical Sketches
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