Sex Differences in Brain Disorders: Emerging Transcriptomic Evidence: Proceedings of a Workshop (2021)
Chapter: Appendix B: Workshop Agenda
B
Workshop Agenda
Sex Differences in Brain Disorders:
Emerging Transcriptomic Evidence and Implications for
Therapeutic Development—A Virtual Workshop
September 23, 2020
Virtual via Zoom
Workshop Objectives: This public workshop will bring together experts and key stakeholders from academia, government, industry, and nonprofit organizations to explore emerging evidence regarding differences in transcriptomic abnormalities that occur in the brains of men versus women with a variety of brain disorders, including depression, posttraumatic stress disorder, drug addiction, neurodegenerative conditions, and others.
Invited presentations and discussions will be designed to:
- Review the landscape of emerging evidence regarding sex differences in transcriptomic abnormalities in a variety of brain disorders, and discuss how this can be used to advance understanding of brain disorder pathophysiology.
- Explore ramifications for therapeutic development for these disorders, including identification of new targets, implications for preclinical and clinical study design, regulatory considerations, and potential sex-specific treatments.
- Discuss open research questions and opportunities to move the field forward.
| 10:00am |
Welcome and Overview of Workshop
ERIC NESTLER, Icahn School of Medicine at Mount Sinai, Workshop Chair |
SESSION I: CURRENT LANDSCAPE OF EMERGING TRANSCRIPTOMIC EVIDENCE FOR SEX DIFFERENCES IN BRAIN DISORDERS
Objectives:
- Provide an overview of the current landscape of emerging evidence regarding sex differences in transcriptomic abnormalities in a variety of brain disorders.
- Consider how this evidence can be used to advance understanding of brain disorder pathophysiology.
| 10:15am |
Session Overview
RITA VALENTINO, National Institute on Drug Abuse, Session Co-Moderator |
Part A: Stress- and Reward-Related Disorders
| 10:20am |
Depression
MARIANNE SENEY, University of Pittsburgh |
| 10:35am |
Posttraumatic Stress Disorder
MATTHEW GIRGENTI, Yale School of Medicine |
| 10:50am |
Addiction
DEENA WALKER, Oregon Health & Science University |
| 11:05am |
Pain
THEODORE PRICE, The University of Texas at Dallas |
| 11:20am |
Panel Discussion:
The speakers above will be joined by panelists: FARAH LUBIN, The University of Alabama at Birmingham ORNA ISSLER, Icahn School of Medicine at Mount Sinai ROHAN PALMER, Emory University |
| 11:40am | General Discussion |
| 12:00pm |
Lunch Break
Attendees will reconvene at 12:40pm for the following lunchtime talk and discussion. |
|
BRAIN Initiative Cell Census Network—Applications to Understanding Sex Differences JOHN NGAI, National Institutes of Health |
Part B: Neurodevelopmental and Neurodegenerative Disorders
| 1:00pm |
Panel Overview
LI GAN, Weill Cornell Medical College, |
| 1:05pm |
Autism
DONNA WERLING, University of Wisconsin–Madison |
| 1:20pm |
Schizophrenia
PANAGIOTIS ROUSSOS, Icahn School of Medicine at Mount Sinai |
| 1:35pm |
Alzheimer’s Disease
TIMOTHY HOHMAN, Vanderbilt University |
| 1:50pm |
Tauopathies
LI GAN, Weill Cornell Medical College |
| 2:05pm |
Panel Discussion
The speakers above will be joined by panelists: BARBARA STRANGER, Northwestern University Feinberg School of Medicine BETH STEVENS, Harvard University NILÜFER ERTEKIN-TANER, Mayo Clinic |
| 2:25pm | General Discussion |
| 2:45pm | BREAK |
SESSION II: MOVING FORWARD—THERAPEUTIC DEVELOPMENT AND POLICY IMPLICATIONS
Objectives:
- Explore ramifications for therapeutic development for brain disorders, including identification of new targets, implications for preclinical and clinical study design, regulatory considerations, and potential sex-specific treatments.
- Discuss open research questions and opportunities to move the field forward.
| 3:00pm |
Session Overview
STEVIN ZORN, MindImmune Therapeutics, Inc., |
| 3:05pm |
Speakers
JANINE CLAYTON, National Institutes of Health KAVEETA VASISHT, Food and Drug Administration DAVID MICHELSON, Regenacy Pharmaceuticals MELISSA LAITNER, Society for Women’s Health Research |
| 3:55pm | Panel Discussion |
| 4:15pm | General Discussion |
| 4:35pm |
Synthesis of Key Workshop Themes and Future Directions
ERIC NESTLER, Icahn School of Medicine at Mount Sinai, Workshop Chair |
| 5:00pm | ADJOURN WORKSHOP |
