February 11, 2021
Web Meeting

11:00 AM (EST)

Opening Remarks

Lisa Bero, Committee Chair

11:05

IRIS Assessments Prior to the Development of the Current IRIS Handbook

Jonathan Samet, Colorado School of Public Health

Questions from Committee Members

12:00 PM

Opportunity for Public Comment

12:20

End of Public Session

April 16, 2021
Web Meeting

10:00 AM (EDT)

Welcome

Lisa Bero, Committee Chair

10:05

Perspectives on EPA’s IRIS Assessment Handbook

Kris Thayer (EPA)

10:50

Committee Discussion with EPA Personnel

Kris Thayer, Xabier Arzuaga, Allen Davis, Laura Dishaw, Catherine Gibbons, Barbara Glenn, Karen Hogan, Dustin Kapraun, Andrew Kraft, Elizabeth Radke, Andy Shapiro, George Woodall, and Erin Yost

11:50

Opportunity for Public Comment

12:50 PM

End of Open Session

Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version
2022

Consensus

Download PDF

You must be logged in to download this publication.

Select Book Type

Paperback - $22.50
Ebook - $18.89

Buy the book

Request an exam or desk copy

The U.S. Environmental Protection Agency's (EPA) Integrated Risk Information System (IRIS) program develops human health assessments that focus on hazard identification and dose-response analyses for chemicals in the environment. The ORD Staff Handbook for Developing IRIS Assessments (the handbook) provides guidance to scientists who perform the IRIS assessments in order to foster consistency in the assessments and enhance transparency about the IRIS assessment process. At the request of the EPA, this report reviews the procedures and considerations for operationalizing the principles of systematic reviews and the methods described in the handbook for determining the scope of the IRIS assessments, evidence integration, extrapolation techniques, dose-response analyses, and characterization of uncertainties.

Publication information

110 pages · 7 x 10 · paperback
ISBN Paperback: 0-309-09088-1
ISBN Ebook: 0-309-09092-X
DOI: https://doi.org/10.17226/26289

Suggested citation

National Academies of Sciences, Engineering, and Medicine. 2022. Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version. Washington, DC: The National Academies Press.

Import this citation to:

Bibtext
EndNote
Reference manager

First Name
Last Name
Email (required)
I agree to receive emails from the National Academies (required)

We respect your privacy and will never share your information.

Search this publication

Front Matter i-xii
Summary 1-12
1 Introduction 13-18
2 Overview of Organization and Content of the Handbook 19-32
3 Planning Assessments 33-51
4 Study Evaluation 52-63
5 Evidence Synthesis 64-69
6 Evidence Integration 70-75
7 Hazard Considerations and Study Selection for Deriving Toxicity Values 76-81
References 82-87
Appendix A: Committee Member Biosketches 88-91
Appendix B: 2020 IRIS Handbook Organization and Contents and EPA Questions to the Committee 92-96
Appendix C: Open Session Agendas 97-98

Log In

Former MyNAP users: You'll need to reset your password on your first login to MyAcademies. Click "Forgot password" below to receive a reset link via email. Having trouble? Visit our FAQ page to contact support.

Members of the National Academy of Sciences, National Academy of Engineering, or National Academy of Medicine should log in through their respective Academy portals.

Email (required)
Password (required)

Don't have an account?

Register

Email (required)
New password (required)
Retype password (required) Password must be at least 8 characters
I accept the terms of use
terms of use

Thank You

Thank you for creating a MyAcademies account!

Enjoy free access to thousands of National Academies' publications, a 10% discount off every purchase, and build your personal library.

Forgot Password

Enter the email address for your MyAcademies (formerly MyNAP) account to receive password reset instructions.

Email (required)

Reset Requested

We sent password reset instructions to your email . Follow the link in that email to create a new password. Didn't receive it? Check your spam folder or contact us for assistance.

Reset Password

New password (required)
Retype password (required) Password must be at least 8 characters

Reset Password

Your password has been reset.

Verify email

Verify Your Email Address

We sent a verification link to your email. Please check your inbox (and spam folder) and follow the link to verify your email address. If you did not receive the email, you can request a new verification link below

Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version (2022)

Chapter: Appendix C: Open Session Agendas

Appendix C

Open Session Agendas

February 11, 2021
Web Meeting

April 16, 2021
Web Meeting

Publication information

Suggested citation

My Academies

Review of U.S. EPA's ORD Staff Handbook for Developing IRIS Assessments: 2020 Version (2022)

Chapter: Appendix C: Open Session Agendas

Appendix C Open Session Agendas

February 11, 2021 Web Meeting

April 16, 2021 Web Meeting

Appendix C

Open Session Agendas

February 11, 2021
Web Meeting

April 16, 2021
Web Meeting