| A&E | architect and engineer |
| ADRB | Architectural Design Review Board |
| AML | Advance Measurements Laboratory |
| ANS | American National Standard |
| ARRA | American Recovery and Reinvestment Act |
| BCI | building condition index |
| BCR | benefit-cost ratio |
| CBO | Congressional Budget Office |
| CFMO | Chief Facilities Management Officer |
| CHP | combined heat and power |
| CI | condition index |
| CMR | construction and major renovations |
| CRF | construction of research facility |
| CRV | current replacement value |
| CTL | Communications Technology Laboratory |
| CUP | central utility plant |
| D-B | design-build |
| DCC | Data Center Coalition |
| DOC | Department of Commerce |
| DoD | Department of Defense |
| DOE | Department of Energy |
| DSRC | David Skaggs Research Center |
| EISA | Energy Independence and Security Act |
| EM | electron microscopy |
| EPA | Environmental Protection Agency |
| ERDC | Army Engineering Research and Development Center |
| ERM | Enterprise Risk Management |
| ERMO | enterprise risk management office |
| ESCO | energy service company |
| ESPC | energy saving performance contract |
| FACA | Federal Advisory Committee Act |
| FCI | facility condition index |
| FEMP | Federal Energy Management Program |
| FF&E | furniture, fixtures, and equipment |
| FIM | facility information system |
| FMEA | failure mode and effect analysis |
| FMF | facilities modernization fund |
| FRPC | Federal Property Management Reform Act |
| FRPP | Federal Real Property Plan |
| FSRM | facilities, sustainment, restoration, and modernization |
| GAO | Government Accountability Office |
| GPL | general purpose laboratory |
| GPRA | Government Performance and Results Act |
| GPS | Global Positioning System |
| GSA | General Services Administration |
| GSF | gross square feet |
| HAC | House Appropriations Committee |
| HVAC | heating, ventilation, and air conditioning |
| IDIQ | indefinite delivery/indefinite quantity |
| IFMA | International Facility Management Association |
| IS | institutional support |
| ISO | International Organization for Standardization |
| IT | information technology |
| LNG | liquified natural gas |
| MEP | Hollings Manufacturing Extension Partnership |
| NASA | National Aeronautics Space Administration |
| NBS | National Bureau of Standards |
| NIH | National Institutes of Health |
| NHPA | National Historic Preservation Act |
| NIST | National Institute of Standards and Technology |
| NFRL | National Fire Research Laboratory |
| NOAA | National Oceanic and Atmospheric Administration |
| NRC | National Research Council |
| NRHP | National Register of Historic Places |
| NSF | net square feet |
| NTIA | National Telecommunications and Information Administration |
| O&M | operations and maintenance |
| OFPM | Office of Facilities and Property Management |
| OMB | Office of Management and Budget |
| OMR | operations, maintenance, and repair |
| OSTP | Office of Science and Technology Policy |
| POR | programs of requirements |
| R&D | research and development |
| RCM | reliability centered maintenance |
| RV | replacement value |
| SCMMR | safety, capacity, maintenance, and major repairs |
| SHPO | State Historic Preservation Office |
| SI | international system of units |
| STRS | Scientific and Technical Research and Services |
| TCO | total cost of ownership |
| TEM | transmission electron microscope |
| UESC | utility energy service contract |
| USACE | U.S. Army Corps of Engineers |
| VCAT | Visiting Committee on Advanced Technology |
| WCF | working capital fund |