Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop (2023)
Chapter: Appendix B: Agenda
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Appendix A: References
B
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
B
Agenda
EXPLORING SLEEP DISTURBANCE IN
CENTRAL NERVOUS SYSTEM DISORDERS
The Keck Center, 500 Fifth Street, NW
Washington, DC 20001
NOVEMBER 2, 2022
ROOM 100
| 9:30–9:35 | Welcome |
| Frances Jensen, University of Pennsylvania; Co-Chair, Forum on Neuroscience and Nervous System Disorders |
|
| 9:35–9:45 | Workshop Overview |
| Louis Ptáček, University of California, San Francisco; Workshop Co-Chair | |
| Heather Snyder, Alzheimer’s Association; Workshop Co-Chair | |
| 9:45–10:15 | Keynote Talk: Current State of Knowledge regarding the Mechanisms, Function, and Characterization of Sleep, including Changes across the Human Life Span |
| Amita Sehgal, University of Pennsylvania; Planning Committee Member |
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
SESSION 1—SLEEP DISORDERS AND SLEEP DISRUPTION IN CNS DISORDERS
- Examine the prevalence and nature of sleep disturbances across CNS disorders to include insomnias, hypersomnias, disorders of the sleep/wake schedule, and parasomnias.
- Discuss methodological gaps in sleep research and the need for standardization and harmonization of approaches.
| 10:15–10:20 | Session Overview |
| Kathleen Merikangas, National Institute of Mental Health; Planning Committee Member; Session Moderator |
|
| 10:20–10:50 | Overview |
| Phyllis Zee, Northwestern University Feinberg School of Medicine | |
| Understanding and Addressing Underlying Determinants of Disparities in Sleep | |
| Dayna Johnson, Emory University | |
| Measurements of Sleep and Rest Activity: Where Are We and Where Would We Like to Go? | |
| Nathaniel Watson, University of Washington School of Medicine | |
| 10:50–11:25 | Moderated Panel Discussion and Audience Q&A |
| Discussants: | |
| Uma Rao, University of California, Irvine; Planning Committee Member | |
| Karla Dzienkowski, Restless Legs Syndrome Foundation | |
| 11:25–11:40 | Break |
SESSION 2—UNDERLYING MECHANISMS OF SLEEP
- Consider opportunities to better understand underlying mechanisms of sleep by leveraging advances from ongoing efforts (e.g., BRAIN Initiative) to integrate behavioral outputs with brain network and neural circuit activity.
- Explore how a genes-first approach can illuminate the bidirectional relationship between disturbed sleep and CNS disorders.
- Consider the impact of altered circadian timing on sleep quantity and quality and associated comorbidities, for example, CNS disorders.
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
| 11:40–11:45 | Session Overview |
| Louis Ptáček, University of California, San Francisco; Workshop Co-Chair; Session Moderator |
|
| 11:45–12:25 | Circadian Timing |
| Erik Herzog, Washington University in St. Louis | |
| Model Systems | |
| David Raizen, University of Pennsylvania | |
| A Genes-First Approach | |
| Ying-Hui Fu, University of California, San Francisco | |
| Neural Circuitry and Cortical Activity | |
| Luis De Lecea, Stanford University | |
| 12:25–1:00 | Moderated Panel Discussion and Audience Q&A |
| Discussant: | |
| John Hogenesch, University of Cincinnati; Cincinnati Children’s Hospital Medical Center | |
| 1:00–2:00 | Lunch |
SESSION 3 (PART A)—RISK AND MITIGATABLE TARGETS FOR BRAIN DISORDERS (PSYCHIATRY)
- Consider potential relationships among disturbed sleep, CNS disorders, and environmental factors associated with both disturbed sleep and increased risk for CNS disorders, including discussing related disparities and approaches to disentangling causal versus contributing factors.
- Explore the potential of sleep as a modifiable target by drugs, devices, and behavioral modifications, as well as a measurable marker related to CNS function, including standardization and common data format requirements to facilitate deeper and cross-therapeutic understanding of sleep.
| 2:00–2:05 | Session Overview |
| John Spiro, Simons Foundation; Planning Committee Member; Session Moderator | |
| 2:05–2:45 | Neurodevelopmental Disorders |
| Ashura Buckley, National Institute of Mental Health Schizophrenia | |
| Dara Manoach, Harvard Medical School | |
| Mood Disorders |
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
| Andrew Krystal (via Zoom), University of California, San Francisco | |
| Industry Perspective | |
| Margaret Moline, Eisai Pharmaceuticals | |
| 2:45–3:20 | Moderated Panel Discussion and Audience Q&A |
| 3:20–3:35 | Break |
| 3:35–4:05 | Biomarkers of Sleep and Sleep Disturbance |
| Aarti Sathyanarayana, Northeastern University | |
| Vadim Zipunnikov, Johns Hopkins University | |
| John Hogenesch, University of Cincinnati; Cincinnati Children’s Hospital Medical Center | |
| 4:05–4:40 | Moderated Discussion and Audience Q&A |
| 4:40–5:00 | Day 1 Synthesis and Preview of Day 2 of the Workshop |
| Louis Ptáček, University of California, San Francisco; Workshop Co-Chair | |
| Heather Snyder, Alzheimer’s Association; Workshop Co-Chair |
NOVEMBER 3, 2022
ROOM 100
| 9:30–9:35 | Welcome and Recap of Day 1 Themes |
| Louis Ptáček, University of California, San Francisco; Workshop Co-Chair | |
| Heather Snyder, Alzheimer’s Association; Workshop Co-Chair |
SESSION 3 (PART B)—RISK AND MODIFIABLE TARGETS FOR BRAIN DISORDERS (NEUROLOGY)
- Consider potential relationships among disturbed sleep, CNS disorders, and environmental factors associated with both disturbed sleep and increased risk for CNS disorders, including discussing related disparities and approaches to disentangling causal versus contributing factors.
- Explore the potential of sleep as a modifiable target by drugs, devices, and behavioral modifications, as well as a measurable marker related to CNS function, including standardization
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
- and common data format requirements to facilitate deeper and cross-therapeutic understanding of sleep.
| 9:35–9:40 | Session Overview |
| Percy Griffin, Alzheimer’s Association; Planning Committee Member; Part 2 Session Moderator | |
| 9:40–10:20 | Neurodegenerative Disorders |
| Erik Musiek, Washington University School of Medicine in St. Louis | |
| Influence of Light on Sleep and Health | |
| Tiffany Schmidt, Northwestern University | |
| Central Nervous System Hypersomnias and Progress in Understanding Narcolepsy | |
| Thomas Scammell, Beth Israel Deaconess Medical Center | |
| Industry Perspective | |
| Hao Wang, Takeda; Planning Committee Member | |
| 10:20–11:15 | Moderated Panel Discussion and Audience Q&A |
| Discussants: | |
| Ying-Hui Fu, University of California, San Francisco | |
| 11:15–12:15 | Lunch |
SESSION 4—SYNTHESIS AND POTENTIAL NEXT STEPS
- Synthesize key themes from the workshop.
- Discuss research gaps and opportunities for cross-disciplinary collaboration between sleep experts and those focused on CNS disorders along the basic to clinical spectrum.
| 12:15–12:20 | Session Overview |
| Clifford Saper, Harvard University; Beth Israel Deaconess Medical Center; Session Moderator | |
| 12:20–1:20 | Panel Discussion |
| Marishka Brown, National Heart, Lung, and Blood Institute | |
| Brian Fiske, Michael J. Fox Foundation for Parkinson’s Research; Planning Committee Member | |
| Morten Grunnet, H. Lundbeck A/S | |
| Matthew Pava, Defense Advanced Research Projects Agency |
Suggested Citation:
"Appendix B: Agenda." National Academies of Sciences, Engineering, and Medicine. 2023. Exploring Sleep Disturbance in Central Nervous System Disorders: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/26938.
| Amita Sehgal, University of Pennsylvania; Planning Committee Member | |
| Andrew Varga, Icahn School of Medicine at Mount Sinai; American Academy of Sleep Medicine | |
| 1:20–1:55 | Audience Q&A |
| 1:55–2:00 | Concluding Remarks |
| Louis Ptáček, University of California, San Francisco; Workshop Co-Chair | |
| 2:00 | Adjourn |
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