Carcinogens and Anticarcinogens in the Human Diet: A Comparison of Naturally Occurring and Synthetic Substances (1996)
Chapter: Appendix C: Chemical Compounds Occurring in Dietary Plants that Have Been . . .
Appendix C
Chemical Compounds Occurring in Dietary Plants that Have Been Reported to Inhibit Carcinogenesis in Vivoa
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
Amino acid |
Cysteine |
1,2-Dimethylhydrazine |
Mouse (po) |
|
|
(DL)-Tryptophan |
Benzidine |
Mouse (po) |
|
Arylheptanoid |
Curcumin |
Methylazoxymethanol; N-Methyl-N'nitroso-urea; Benzo(a)pyrene; TPA; TPA; 20-Methylcholanthrene; DMBA + Croton oil |
Mouse (po); Rat (po); Rat (po); Mouse (ext); Mouse (ip); Mouse (sc); Mouse (ext) |
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
Benzenoid |
Gingerol |
Azoxymethane |
Rat (po) |
|
Carotenoid |
Canthaxanthin |
Benzo(a)pyrene; DMBA |
Mouse (po); rat (po) |
|
Carotenoid |
-Carotenal, 8-Apo |
Benzo(a)pyrene |
Mouse (po) |
|
|
-Carotene |
Spontaneous liver CA |
Mouse (po) |
|
|
-Carotene |
Benzo(a)pyrene; N-methyl-N'-nitroso-urea; DMN-OAC; DMBA |
Mouse (ext); Rat; Hamster (po); Mouse (ext) |
|
|
Fucoxanthin |
N-Ethyl-N'-Nitro-N-nitroso-guanidine |
Mouse (po) |
|
Coumarin |
Aesculetin |
DMBA |
Rat (po) |
|
|
Coumarin |
Benzo(a)pyrene |
Mouse (po) |
|
|
Umbelliferone |
Benzo(a)pyrene |
Mouse (po) |
|
Cyclitol |
Myoinositol |
|
Mouse (po) |
|
|
Phytic acidc |
DMBA |
Rabbit (po) |
|
Diterpene |
Cafestol |
DMBA |
Hamster (po) |
|
|
Cafestol Palmitate |
DMBA |
Rat (po) |
|
|
Kahweol |
DMBA |
Hamster (po) |
|
Flavonoid |
Amorphinospirone |
TPA |
Mouse (ext) |
|
|
Apigenin |
DMBA/TPA |
Mouse (ext) |
|
|
Myricetin |
DMBA + Benzo(a)pyrene + TPA |
Mouse |
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
|
Quercetinc |
Azoxymethanol; DMBA; Teleocidin; Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol epoxide |
Mouse (po); Rat (po); Mouse (ext); Mouse (ext); Mouse (ip); Mouse (ip) |
|
|
Robinetin |
Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol |
Mouse (ext); Mouse (ip); Mouse (ip) |
|
|
Rutin |
Azoxymethanol |
Mouse (po) |
|
Indole Alkaloid |
Indole-3-carbinol |
4-Nitroquinoline-1-oxide; Diethylnitrosamine +; N-methylnitrosourea +; N,N-dibutyl-nitrosamine; Spontaneous mammary tumors |
Rat (po); Rat (po); Mouse (po) |
|
Isoflavonoid |
Biochanin A |
Benzo(a)pyrone |
Mouse (ip) |
|
Lactone |
-Angelicalactone |
Benzo(a)pyrene |
Mouse (po) |
|
Lignan |
Sesamin |
DMBA |
Rat (po) |
|
Monoterpene |
Carveol |
DMBA |
Rat (po) |
|
|
Limonenec |
DMBA; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone; Same; N-Ethyl-N-Hydroxy-nitrosamine |
Rat (po); Rat (po); Rat (ip); Rat (po) |
|
|
(-) Menthol |
DMBA |
Rat (po) |
|
|
para-Mentha-2-8-dien-1-ol |
Benzo(a)pyrene |
Mouse (po) |
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
Organic acid |
Fumaric acid |
N-Methyl-N'-nitroso-urea; N-Methyl-N-benzylnitrosoamine; N-Ethyl-N-nitrosurea; 3'-Methyl-4-(Dimethylamino)azobenzene |
Hamster (po); Rat (po); Rat (po); Rat (po) |
|
Phenolic acid |
Gallic acid |
|
Mouse (po) |
|
|
Protocatechuic acid |
Azoxymethane |
Rat (po) |
|
Phenylpropanoid |
Caffeic acid |
4-Nitroquinoline-1-oxide Benzo(a)pyrene |
Rat (po); mouse (po) |
|
|
Chlorogenic acid |
4-Nitroquinoline-1-oxide |
Rat (po) |
|
|
Cinnamic acid, ortho-hydroxy |
Benzo(a)pyrene |
Mouse (po) |
|
|
Eugenolc |
DMBA |
Mouse (ext) |
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
|
Diallysulfide |
Nitrosomethylbenzylamine; DMBA; DMBA; DMBA or TPA; MNNG; 1,2-Dimethylhydrazine; Diethylnitrosamine; + N-methylnitrosourea; + N,N-dibutylnitrosamine; N-Nitrosodiethylamine; 4-(Methylnitrosoamino)-1 butanone; N-Nitrosodimethylamine |
Rat (po); Hamster (po); Rat (po); Mouse (ext); Rat (po); Mouse (po); Pig (po); Rat (ip); Rat (ip); Rat (ip) |
|
|
Benzyl isothiocyanate |
Diethylnitrosamine; Diethylnitrosamine; Benzo(a)pyrene; NNK; 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone |
Rat (po); Mouse (po); Mouse (po); Mouse (po); Mouse (po) |
|
|
Isothiocyanate, Phenethyl |
4-(Methylnitrosamino)-1-(3- pyridyl)-1- butanone; N-Nitrosomethylbenqyl-amine; Same; NNK |
Mouse (po); Rat (po); Mouse (po); Mouse (po) |
|
|
Sinigrin |
4-Nitroquinoline-1-oxide |
Rat (po) |
|
Tannin |
Ellagic acid |
4-(methylnitrosamino-1-(3- Pyridyl)-1- butanone; 4-Nitroquinoline-1-oxide; N-Nitrosobenzmethylamine; Azoxymethane; DMBA; Benzo(a)pyrene; Benzo(a)pyrene; Benzo(a)pyrene diol epoxide; Benzo(a)pyrene diol epoxide; 3-Methylcholanthrene |
Mouse (po); Rat (po); Rat (po); Rat (po); Rat (po); Mouse (ext); Mouse (ip); Mouse (ext); Mouse (ip); Mouse (po) |
|
Class |
Compound Name |
Inducer |
Species (Routeb) |
|
|
(-)-Epigallocatechin-3- gallate |
X-ray; Spontaneous liver tumors; N-Ethyl-N'Nitro-N- nitrosoguanidine; Nitrosamine-4-(methyl- nitrosamino)-1-(3- pyridyl)-1-butanone |
Rodents; Mouse (po); Mouse (po); Mouse (po); Mouse (po) |
|
|
Tannic acid |
DMBA + benzo(a)pyrene +; TPA; Benzo(a)pyrene |
Mouse; Mouse (po) |
|
Triterpene |
Glycyrrhetinic acid |
Teleocidin; Azoxymethane; Methylazoxymethane; DMBA; DMBA or TPA |
Mouse (ext); Rat (po); Mouse (po); Mouse (po); Mouse (ext) |
|
|
Limonin |
DMBA |
Hamster (ext) |
|
|
Oleanolic acid |
Azoxymethane; DMBA; TPA |
Rat (po); Mouse (ext); Mouse (ext) |
|
|
Ursolic acid |
DMBA; TPA |
Mouse (ext); Mouse (ext) |
|
Triterpene glycoside |
Glycyrrhizin |
DMBA |
Mouse (po) |
|
Xanthine Alkaloid |
Caffeinec |
Estradiol + progesterone; Diethylstilbestrol |
Mouse (po) rat (ip) |
|
a Data obtained from the NAPRALERT database of natural products. On-line access is available through the Scientific and Technical Network (STN) of Chemical Abstract Services. Data presented are intended to be illustrative but may not be complete. b The following abbreviations are used to indicate route:
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c Plant species containing this compound are listed in Appendix A. |
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