Review of Acute Human-Toxicity Estimates for Selected Chemical-Warfare Agents (1997)
Chapter: Lethal Effects (LCt50)
5—
Review of Acute Human-Toxicity Estimates for GF
GF (cyclohexyl methylphosphonofluoridate) is an organophosphate nerve agent. The physical and chemical properties, toxicokinetics, and toxicity of GF are discussed in detail by CDEPAT(1994), Marrs et al. (1996), and Somani (1994). Human-toxicity estimates have been derived for percutaneous vapor exposures, vapor inhalation exposures, and for percutaneous liquid exposures. Only a few toxicity end points were considered; they include lethality and cholinesterase (ChE) inhibition in humans and animals. The subcommittee's assessment of the scientific validity of CDEPAT's proposed human-toxicity estimates for GF is discussed below.
Percutaneous Vapor Exposure
Lethal Effects (LCt50)
CDEPAT's proposed LCt50 estimate for percutaneous exposure to GF vapor is 2,500 mg-min/m3, assuming exposure durations of 30 to 50 min and
