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Appendix B
Workshop Agendas

Workshop on Perspectives on the Medical Use of Marijuana:
Basic and Clinical Science

December 14-16, 1997 Beckman Center, Irvine, California

AGENDA

Sunday, December 14,1997

2:00 p.m.  Introduction
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health

2:30 p.m.  Public Input Session, 5 minutes per person
Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan

5:30 p.m.  ADJOURN

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Monday, December 15, 1997

CANNABINOID NEUROSCIENCE

8:30 a.m.  Moderator: Stanley Watson, IOM Study Investigator,
University of Michigan

8:45 a.m.  Neuropharmacology of Cannabinoids and Their Receptors
Steven R. Childers, Wake Forest University School of Medicine

9:15 a.m.  Precipitated Cannabinoid Withdrawal and Sensory Processing of Painful Stimuli
J. Michael Walker, Brown University

9:45 a.m.  Role of Cannabinoids in Movement
Clara Sanudo, Brown University

10:15 a.m. Tolerance and Cannabinoid-Opioid Interactions
Sandra P. Welch, Medical College of Virginia

10:45 a.m. BREAK

MEDICAL USES OF MARIJUANA:
CLINICAL DATA AND BASIC BIOLOGY

11:10 a.m. Moderator: John A. Benson, Jr., IOM Study Investigator,
Oregon Health Sciences University

11:15 a.m. Profile of Medical Marijuana Users
John Mendelson, University of California at San Francisco

11:45 a.m. Immune Modulation by Cannabinoids
Norbert Kaminski, Michigan State University

12:15 p.m. Psychological Effects of Marijuana Use
Charles R. Schuster, Wayne State University

12:45 p.m. LUNCH

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1:45 p.m.  Marijuana and Glaucoma
Paul Kaufman, University of Wisconsin

2:15 p.m.  Effects of Marijuana and Cannabinoids in Neurological Disorders
Paul Consroe, University of Arizona Health Sciences Center

2:45 p.m.  Neural Mechanisms of Cannabinoid Analgesia
Howard Fields, University of California at San Francisco

3:15 p.m. Pain Management
Michael Rowbotham, University of California at San Francisco

3:45 p.m.  Wasting Syndrome Pathogenesis and Clinical Markers
Donald Kotler, St. Luke's-Roosevelt Hospital

4:15 p.m.  Clinical Experience with Marijuana
Stephen O'Brien, East Bay AIDS Center

4:45 p.m. ADJOURN

Tuesday, December 16,1997

MEDICAL USES OF MARIJUANA:
CLINICAL DATA AND BASIC BIOLOGY

8:30 a.m.  Moderator: John A. Benson, Jr., IOM Study Investigator,
Oregon Health Sciences University

8:45 a.m.  Marijuana in AIDS Wasting: Tribulations and Trials Donald I. Abrams,
University of California at San Francisco

9:15 a.m.  Nausea and Vomiting: Underlying Mechanisms and Upcoming Treatments Alan D. Miller, The Rockefeller University

9:45 a.m.  Postchemotherapy Nausea and Antiemetics
Richard J. Gralla, Ochsner Cancer Center

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10:15 a.m. BREAK

SUMMARY VIEWS

10:30 a.m. Marijuana Is Different from THC: A Review of Basic Research and State Studies of Antiemesis
Richard E. Musty, University of Vermont

11:00 a.m. Medical Uses of Crude Marijuana: Medical and Social Issues
Eric A. Voth, The International Drug Strategy Institute

11:30 a.m. General Questions Moderator:
John A. Benson, Jr., IOM Study Investigator

12:00 noon ADJOURN

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Workshop on Acute and Chronic Effects of Marijuana Use

January 22-23, 1998
New Orleans Marriott Hotel
New Orleans, Louisiana

AGENDA

Thursday, January 22, 1998

2:00 p.m.  Introduction
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health

2:30 p.m.  Public Input Session, 5 minutes per person Moderator: Stanley Watson, Jr., IOM Study Investigator, University of Michigan

4:30 p.m. ADJOURN

Friday, January 23, 1998

8:30 a.m.  Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University

HEALTH CONSEQUENCES OF MARIJUANA USE

9:00 a.m.  Health Consequences of Marijuana Use: Epidemiological Studies Stephen Sidney, Kaiser Permanente, Oakland, CA

9:30 a.m.  Immunity, Infections, and Cannabinoids Thomas Klein, University of South Florida

10:00 a.m. Pulmonary Effects of Smoked Marijuana Donald Tashkin, Unversity of California at Los Angeles

10:30 a.m. BREAK

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10:45 a.m. Is Marijuana Carcinogenic?: Epidemiological and Biological Evidence

Panel Discussion
Stephen Sidney Donald Tashkin

12:00 noon    LUNCH

EFFECTS OF MARIJUANA ON BEHAVIOR

1:30 p.m.  Marijuana: Addictive and Amotivational States, the Scientific Evidence
John Morgan, City University of New York Medical School

2:00 p.m.  Marijuana's Acute Behavioral Effects in Humans
Richard Foltin, Columbia University

2:30 p.m.  Tolerance and Dependence Following Chronic Administration of Oral THC or Smoked Marijuana to Humans
Margaret Haney, Columbia University

3:00 p.m.  Patterns of Continuity and Discontinuity of Marijuana Use in Relationship to Other Drugs
Robert Pandina, Rutgers University

3:30 p.m.  ADJOURN

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Workshop on Prospects for Cannabinoid Drug Development

February 23-24, 1998
National Academy of Sciences Building
Washington, D.C.

AGENDA

Monday, February 23,1998

1:30 p.m.  Introduction
Constance Pechura, IOM Division Director, Neuroscience and Behavioral Health

2:00 p.m.  Public Input Session, 5 minutes per person
Moderator: John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University

5:30 p.m.  ADJOURN

Tuesday, February 24,1998

8:30 a.m.  Introduction Constance Pechura, IOM Division Director Neuroscience and Behavioral Health

Moderator: Stanley J. Watson, Jr., IOM Study Investigator, University of Michigan

OVERVIEWS OF PRECEDING WORKSHOPS

8:45 a.m.  Acute and Chronic Effects of Marijuana
Billy R. Martin, Medical College of Virginia

9:25 a.m.  Perspectives on the Medical Use of Marijuana
Eric B. Larson, University of Washington Medical School

9:55 a.m.  The Neurobiology of Cannabinoid Dependence
George F. Koob, Scripps Research Institute

10:25 a.m. BREAK

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DRUG DEVELOPMENT

10:45 a.m. Regulatory Requirements Affecting Marijuana
J. Richard Crout, Crout Consulting

11:15 a.m. Marinol and the Market
Robert E. Dudley, Unimed Pharmaceuticals, Inc.

11:45 a.m. Development of Cannabis-based Therapeutics
Dave Pate, HortaPharm, B.V.

12:15 p.m. LUNCH

DRUG DELIVERY

1:30 p.m.  Alternative Drug Delivery Technologies for the Therapeutic Use of Marijuana
Phyllis I. Gardner, ALZA Corporation, Stanford University

2:00 p.m.  Delivery of Analgesics via the Respiratory Track
Reid M. Rubsamen, Aradigm Corporation

2:30 p.m.  Current Concepts for Delivery of THC
Mahendra G. Dedhiya, Roxanne Laboratories, Inc.

3:00 p.m.  D⁹-THC-Hemisuccinate in Suppository Formulation: An Alternative to Oral and Smoked
THC Mahmoud A. ElSohly, University of Mississippi, ElSohly Laboratories, Inc.

3:30 p.m. Concluding Remarks
John A. Benson, Jr., IOM Study Investigator, Oregon Health Sciences University

3:45 p.m. ADJOURN