Evaluation of the Protocol for the IRIS Toxicological Review of Inorganic Arsenic

Meeting

Inorganic Arsenic Meeting

July 16, 2019

6:00 AM - 5:30 PM (EDT)

Past

Agenda

About

The National Academies of Sciences, Engineering, and Medicine has convened a committee of experts to conduct a study that will review the U.S. Environmental Protection Agency Integrated Risk Information System program’s approaches to conducting a toxicological assessment of inorganic arsenic.

Additional Information

Is it a Closed Session event?

Partially Closed

The following committee members were present at the closed sessions of the event

Aaron Barchowsky, Hugh Barton, Margaret Karagas, Ana Navas-Acien, Michael Pennell, Karen Robinson, J. Christopher States, Daniele Wikoff, Carol Wood, and Robert Wright

The following topics were discussed in the closed sessions:

1) Committee’s statement of task and its approach to its task.
2) Information presented during the open session.
3) Committee assignments and project schedule.

The following materials (written documents) were made available to the committee in the closed sessions:

iAs-1
Steven Lamm, Center for Epidemiology and Environmental Health
July 9, 2019
Email with attachments
J. Ahn, H. Ferdosi, and SH. Lamm. 2017. Poster: Aortic Elasticity and Arsenic Exposure – a step function rather than a linear function. Presented at SOT.

iAs-2
Thomas B. Starr, TBS Associates
July 11, 2019
Email with attachment
Starr, TB. 2019. Technical Comments on the USEPA Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment. Submitted to Docket ID No. EPA-HQ-ORD-2012-0830 for Inorganic Arsenic.

iAs-3
William Adams, Arsenic Science Task Force
July 11, 2019
Email with attachment

Arsenic Science Task Force. 2019. Comments on the “Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment” [EPA-HQ-ORD-2012-0830; FRL-9994-24-ORD].

iAs-4
Samuel M. Cohen, University of Nebraska Medical Center
July 12, 2019
Email with attachment
Cohen, SM. 2019. Comments to EPA regarding the draft protocol for the inorganic arsenic risk assessment. (Docket: EPA-HQ-ORD-2012-0830)

iAs-5
Joyce S. Tsuji, Exponent
July 12, 2019
Email with attachment
a. Tsuji, JS. 2019. Comments on EPA’s Updated Problem Formulation and Protocol for the Inorganic Arsenic IRIS Assessment. Docket ID No. EPA–HQ–ORD–2012– 0830 for Inorganic Arsenic.
b. Tsuji, JS, V Perez, MR Garry, and DD Alexander. 2014. Association of low-level arsenic exposure in drinking water with cardiovascular disease: A systematic review and risk assessment. Toxicology 323: 78–94.
c. Tsuji, JS, MR. Garry, V Perez, and ET Chang. 2015. Low-level arsenic exposure and developmental neurotoxicity in children: A systematic review and risk assessment. Toxicology 337: 91–107.
d. Tsuji, JS, ET Chang, PR Gentry, HJ Clewell, P Boffetta, and SM Cohen. 2019. Dose-response for assessing the cancer risk of inorganic arsenic in drinking water: the scientific basis for use of a threshold approach. Critical Reviews in Toxicology, DOI: 10.1080/10408444.2019.1573804.

iAs-6
Lorenz R. Rhomberg, Gradient
July 12, 2019
Email with attachment
Rhomberg, LR, JE Goodman, and JM Cohen. 2019. Comments on EPA's Updated Problem Formulation and Protocol for the Inorganic Arsenic Integrated Risk Information System Assessment. Submission to EPA Docket ID: EPA-HQ-ORD-2012-0830.

iAs-7
Dahnish Shams, Office of Research and Development, U.S. EPA
July 15, 2019
Email with attachments
a. Thayer, K. 2019. Introduction and Role of the Protocol in the IRIS Systematic Review Process. PowerPoint Presentation
b. Lee, J, I Druwe, J Gift, and A Davis. 2019. Updated Problem Formulation and Scoping. PowerPoint Presentation
c. Lee, J, E Kirrane, and T Luben. 2019. Systematic Review Methods Used to Prioritize Health Outcomes. PowerPoint Presentation
d. Davis, A, and J Gift. 2019. Inorganic Arsenic IRIS Dose-Response Analyses. PowerPoint Presentation.
e. Summary of Public Comments Received on IRIS Inorganic Arsenic Protocol for Transmittal to NAS Committee. Docket: EPA-HQ-ORD-2012-0830-0040

iAs-8
Janice S. Lee, Office of Research and Development, U.S. EPA
July 16, 2019
Poster
Lee, JS, I Cote, T Luben, E Kirrane, R Jones, J Gift, JA Davis, I Druwe, A Turley, M Cawley, R Blain, S Eftim, and K Thayer. 2019. Systematic Review Methods and Hazard Characterization for the Updated Problem Formulation and Protocol for the Inorganic Arsenic (iAs) IRIS Assessment (Poster 1).

iAs-9
Ingrid L. Druwe, Office of Research and Development, U.S. EPA
July 16, 2019
Poster
Druwe, IL, JA Davis, L Burgoon, J Gift , I Cote, and JS Lee. 2019. Building an Adverse Outcome Pathway Network for Arsenic-Induced Bladder Cancer (Poster 2).

iAs-10
Janice S. Lee, Office of Research and Development, U.S. EPA
July 16, 2019
Poster
El Masri, H, T Hong, C Henning, W Mendez Jr., E Hudgens, D Thomas, and JS Lee. 2019. Evaluation of a Physiologically-based Pharmacokinetic (PBPK) Model for Inorganic Arsenic (iAs) Exposure Using Data from Two Diverse Human Populations (Poster 3).

iAs11
Jeff Gift, Office of Research and Development, U.S. EPA
July 16, 2019
Poster
Hobbie, K, JA Davis, K Shao, C Henning, W Mendez, Jr., JS Lee, I Cote, I Druwe, and J Gift. 2019. Analyzing Study-Specific Estimates of Exposures Associated with a Defined Relative Risk vs U.S. Background Exposure (RRBs) for Inorganic Arsenic (iAs) Health Outcome (Poster 4).

iAs12
Jeff Gift, Office of Research and Development, U.S. EPA
July 16, 2019
Poster
Mendez, Jr., W, JA Davis, K Shao, JS Lee, I Cote, I Druwe, and J Gift. 2019. The Application of Model Averaging Methods to Assess the Suitability of Taiwanese Studies for Predicting U.S. Bladder and Lung Cancer Risk from Inorganic Arsenic (iAs) Intake (Poster 5).

iAs-13
J. Allen Davis, Office of Research and Development-Cincinnati, U.S. EPA
July 16, 2019
Poster
Allen, B, J Gift, K Shao, K Hobbie, W Mendez, Jr., JS Lee, I Cote, I Druwe, and JA Davis. 2019. Bayesian Hierarchical Meta-Regression of Epidemiologic Studies: Dose and Response Pre-Analysis (Poster 6.)

iAs-14
J. Allen Davis, Office of Research and Development-Cincinnati, U.S. EPA
July 16, 2019
Poster
Allen, B, J Gift, K Shao, K Hobbie, W Mendez, Jr., JS Lee, I Cote, I Druwe, and JA Davis. 2019. Bayesian Hierarchical Meta-Regression of Epidemiologic Studies: Dose-Response Modeling and Target Population Predictions (Poster 7).

iAs-15
Kevin L. Bromberg, US Small Business Administration
July 16, 2019
Email with attachment
Bromberg, KL. 2019. Written Comments to the National Research Council Evaluation of the Protocol for the IRIS Toxicological Review of Inorganic Arsenic.

iAs-16
Steven Lamm, Center for Epidemiology and Environmental Health
July 16, 2019
Email with attachments
a. Lamm, SH, IJ Boroje, H Ferdosi, and J Ahn. 2019. Non-Linearity and Data Effects in Arsenic Risk. PowerPoint Presentation
b. Lamm, SH, IJ Boroje, H Ferdosi, and J Ahn. 2019. Submission to: Docket ID No. EPA–HQ–ORD–2012– 0830 for Inorganic Arsenic.
c. Kramer Z., IJ Boroje, H Ferdosi, J Ahn, and SH Lamm. 2019. Low Arsenic Levels in Drinking Water Sources and Prostate Cancer Risk in US Counties (2009-2013) –a Linear-Quadratic Fit (Poster)

Date of posting of Closed Session Summary:

July 25, 2019

Contact

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Location

National Academy of Sciences Building

2101 Constitution Ave NW

Washington DC 20418, USA

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Evaluation of the Protocol for the IRIS Toxicological Review of Inorganic Arsenic

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