An ad hoc planning committee of the National Academies of Sciences, Engineering, and Medicine will organize a workshop to review federal agency research on perfluoroalkyl and polyfluoroalkyl substances and to identify research and data gaps. Topics may include the following:

1) Human health hazards, including

a. Identification and characterization of health effects or bioactivities of interest in human populations.

b. Criteria/factors to be considered when addressing a variety of different health effects within the decision-making process (e.g., severity vs. dose).

c. Approaches for extrapolating from animal health effects to human health effects.

d. Toxicokinetic and toxicodynamic issues related to extrapolating across species. For example, will toxicokinetic research increase understanding related to the default assumption of toxicity increasing in direct relationship with the half-life of PFAS? Will toxicodynamic research increase understanding of cross-species sensitivity for health effects (such as immune, liver, thyroid, reproductive/development effects)?

e. Approach(es) for identification and use of PFAS additivity, synergism, or antagonism.

f. Potential benefits of defining a class-based approach to characterizing PFAS health effects.

2) Human exposures, including

a. Approaches for prospective biomonitoring of human populations at greatest risk.

b. Identification of exposure sources and potential exposure pathways including the determination of relative source contribution and fate and transport for the different exposure pathways (e.g., water, air).

c. Consideration of potential ecotoxicological and ecotoxicokinetic issues which may impact human exposures, e.g. through agricultural or subsistence food web pathways.