An ad hoc committee will organize and conduct a public workshop to discuss fundamental aspects of experimental design of research using animals and animal models, aimed at improving reproducibility. The workshop will include invited speakers to provide background and context on how to ensure that animal studies are of sufficient quality and relevance, and described in adequate detail for the findings to provide an evidence base for any decision to proceed into clinical trials or other outcomes of public importance. The ad hoc committee will develop a workshop agenda, select and invite speakers and discussants, and moderate the workshop discussions. An individually-authored brief summary of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.