An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine will undertake a study to assess options presented in the document Options for Consideration of Chronic Disease Endpoints for Dietary Reference Intakes: Summary Report from a Joint US/Canadian-sponsored Expert Panel and determine guiding principles for the inclusion of chronic disease endpoints for food substances that will be used by future committees in establishing Dietary Reference Intakes. The committee shall provide justification for the selection (and non-selection) of options that served as the basis for the guiding principles.