The Food Forum of the National Academies of Sciences, Engineering, and Medicine hosted a public workshop that reviewed current knowledge in the field of nutrigenomics as it relates to nutrition. The workshop explored the influence of genetic and epigenetic expression on nutritional status, including the potential impact of personalized nutrition on health maintenance and chronic disease prevention. The workshop also investigated the clinical implications of nutrigenomics, key public health and regulatory policy considerations presented in the context of emerging nutrigenomics applications to personalized nutrition, and the challenges to globalization of public health guidance that may be informed by nutrigenomic research.