An ad hoc committee of the National Academies of Sciences, Engineering, and Medicine will convene to review and assess NASA's processes for long-term risk assessment and management for currently anticipated crewed missions with respect to cancer (excluding current and post mission effects of radiation) due to exposure to space radiation. Specifically, the committee will:

• Review the data on the association between radiation exposure and cancer risk, and consider the best ways for NASA to apply the data to manage the risk assessment process to currently anticipated crewed missions. With respect to NASA processes, the review will consider a broad range of factors and analytic techniques that may include uncertainty management utilizing confidence intervals around cancer mortality, radiation quality factor determination and utilization, and the use of the dose and dose-rate effectiveness factor (DDREF).
• Review and assess NASA's proposed process and strategies for managing cancer risks as a result of exposure to space radiation. Provide a written report with recommendations on the best process and strategies for NASA to use in addressing and managing the uncertainties of long-term cancer risks due to radiation exposure in crewed space missions beyond low Earth orbit.

In conducting the review the committee will consider the following:

• NASA's present processes for assessing uncertainty from radiation risk exposure in crewed space missions compared to terrestrial methods for clinical applications, and how data from ground-based research on the relationship between radiation exposure and cancer risk should inform NASA's approach to risk management for crewed missions.
• How to consistently manage the uncertainty of space radiation exposure risk assessments across spaceflight with respect to anticipated NASA space missions, and known clinical risks.
• How to express what is needed in the form of a radiation risk management process or approach NASA could apply to determine astronaut eligibility for crewed missions.

Based on the committee's review and assessment of NASA's proposed strategies, the committee will make recommendations to NASA for assessing and managing the processes for addressing space radiation risk for astronauts.