Examining Glucagon-Like Peptide-1 Receptor (GLP-1R) Agonists for Central Nervous System Disorders: A Workshop

Workshop

September 10, 2024

9:00 AM - 4:30 PM (ET)

Past

Materials

About

A planning committee of the National Academies of Sciences, Engineering, and Medicine hosted a one-day public workshop that brought together leaders and experts from academia, industry, government, philanthropic foundations, and disease-focused non-profit organizations across disciplines (e.g., neuroscience, pharmacology, medicine, and endocrinology) to examine potential applications of glucagon-like peptide-1 receptor (GLP-1R) agonists in central nervous system disorders, such as dementia, Parkinson’s disease, substance and alcohol use disorders, and pain.

Invited presentations and discussions:

Reviewed the current state of knowledge regarding the mechanisms of action of GLP-1R agonists and their therapeutic applications across different disease areas.
Discussed available scientific evidence on the clinical efficacy of GLP-1R agonists, among other considerations, for treating various central nervous system disorders, including neurodegenerative diseases, and alcohol and substance use disorders, and for pain management.
Examined regulatory challenges and opportunities surrounding the application of GLP-1R agonists as therapeutic treatments for central nervous system disorders.
Highlighted current research gaps and consider opportunities to move the field forward.

A planning committee developed the agenda for the workshop, selected and invited speakers and discussants, and moderated the discussions. Following the workshop, proceedings of the presentations and discussions will be prepared by a designated rapporteur in accordance with institutional guidelines.

The recordings from the workshop will be available within 7-10 business days after the workshop concludes.

Contact

Kimberly Ogun

kogun@nas.edu

Location

Keck Center

500 5th St NW

Washington DC 20001, USA

Disclaimer

It is essential to the National Academies mission of providing evidence-based advice that participants in any of our meetings or events avoid political or partisan statements or commentary and maintain a culture of mutual respect. The statements and presentations during our meetings or events are solely those of the individual participants and do not necessarily represent the views of other participants or the National Academy of Sciences, which is a non-partisan, tax exempt organization that includes under its Charter the National Academy of Engineering and National Academy of Medicine, and that operates the National Research Council.

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Examining Glucagon-Like Peptide-1 Receptor (GLP-1R) Agonists for Central Nervous System Disorders: A Workshop

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Examining Glucagon-Like Peptide-1 Receptor (GLP-1R) Agonists for Central Nervous System Disorders: A Workshop