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The National Cancer Policy Forum convened a public workshop that included presentations and panel discussions exploring strategies to reduce tobacco-related cancer incidence and mortality. Tobacco use is responsible for more than 440,000 deaths each year and is the leading cause of preventable deaths in the United States. Around 30 percent of tobacco-related deaths in the United States are due to cancer. Tobacco use increases the incidence of many types of cancer and also can affect treatment outcomes. New efforts are needed to reduce smoking initiation and encourage cessation, including among individuals who have been diagnosed with cancer.