The COVID-19 pandemic has placed renewed focus on strengthening the capability of U.S. foreign and development policy. Similarly, great power competition, urgent existential threats such as climate change, and rapidly advancing emerging technologies underscore the importance of assessing how science, technology and health are integrated into American diplomatic and development missions – and whether the U.S. DOS and USAID are maximally leveraging STH to meet pressing challenges in a changing world. This workshop will explore strengthening the role of STH at DOS and USAID and achieve U.S diplomatic and development goals in the next 5-10 years.