Since 1990, the Academies has been engaged in a program of workshops, exchange visits, and scientific consultations with the Iranian Academy of Sciences, the Iranian Academy of Medical Sciences, and other institutions in Iran. A report describing these activities was published in 2010.

Both the Iranian Academies and the U.S. National Academies of Sciences, Engineering, and Medicine continue to foster cooperative relations between scientific and intellectual leaders and government officials from both nations through meetings of experts, individual visits in both directions, and continued consultations. Areas of near-term interest include climate change, resilient cities, and water and air pollution.