The National Academies of Sciences, Engineering and Medicine (NASEM), in collaboration with the Kavli Foundation and Issues in Science and Technology, will host a hybrid symposium in Fall 2022 on research and higher education institutions for the next 75 years. The symposium will be a follow up to the February 2020 symposium “The Endless Frontier: The Next 75 Years in Science,” which celebrated the 75th anniversary of Vannevar Bush’s report. The 2022 symposium will spotlight the transformations of the research and higher education institutions needed in the next 75 years to better address complex, global challenges like climate change and the interface between emerging technologies and society, in addition to pandemics, nurture the future workforce, advance innovations, and serve as trusted, responsible members of society. Some of the issues to be discussed could include: new entities needed for research and technology translation; capacity and flexibility of community colleges and vocational training institutions to support larger technical workforce; higher education structures and programs to address STEM diversity; and innovative organizational structures of research centers to address complex missions. Given the global nature of science, the symposium will include presentations from international perspectives, identifying examples that may serve to inform the needed transformations in the United States. This activity will produce a written proceedings and hold extensive communication activities.