On September 22, 2022 the National Academies of Sciences, Engineering and Medicine (NASEM), in collaboration with the Kavli Foundation and Issues in Science and Technology, will host the “Endless Frontier Symposium 2022: Research and Higher Education Institutions for the Next 75 Years.” This symposium is a follow up to the February 2020 symposium, and will bring together experts and leaders from across the world to consider transformations needed from research and higher education institutions in the next 75 years to better address complex, global challenges like the impacts of pandemics, advancing innovation, building and nurturing capacity, and so much more.