The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use (2020)
Chapter: Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients
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Previous Chapter:
Appendix F: Compounded Bioidentical Hormone Therapy Formulations with a Single Active Ingredient
Next Chapter: Appendix H: Boxed Warnings on U.S. Food and Drug AdministrationApproved Estrogen and Testosterone Products
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 1 | Dehydroepiandrosterone Pregnenolone | Capsule | Dehydroepiandrosterone Sodium Sulfate Anhydrous; Pregnenolone | 15 mg; 75 mg |
| 2 | Dehydroepiandrosterone Pregnenolone | Suspension | Dehydroepiandrosterone Sodium Sulfate Anhydrous; Pregnenolone | 16 mg/1 mL; 40 mg/1 mL |
| 3 | Dehydroepiandrosterone Testosterone | Cream | Testosterone; Dehydroepiandrosterone | 20 mg/1 mL; 200 mg/1 mL |
| 4 | Dehydroepiandrosterone Testosterone | Gel | Dehydroepiandrosterone; Testosterone | 15 mg/1 mL; 4 mg/1 mL |
| 5 | Dehydroepiandrosterone Testosterone | Lozenge | Testosterone; Dehydroepiandrosterone | 2 mg; 15 mg |
| 6 | Estradiol Progesterone | Capsule | Estradiol; Progesterone | 0.25 mg; 100 mg |
| 7 | Estradiol Progesterone | Cream | Estradiol; Progesterone | 0.4 mg/1 mL; 40 mg/1 mL |
| 8 | Estradiol Progesterone | Cream | Estradiol; Progesterone | 0.65 mg/1 mL; 125 mg/1 mL |
| 9 | Estradiol Progesterone | Cream | Estradiol; Progesterone | 1.2 mg/1 mL; 150 mg/1 mL |
| 10 | Estradiol Progesterone | Cream | Estradiol; Progesterone | 4.2 mg/1 mL; 200 mg/1 mL |
| 11 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.09 mg; 0.36 mg |
| 12 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.25 mg; 0.25 mg |
| 13 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.25 mg; 1 mg |
| 14 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.3 mg; 0.3 mg |
| 15 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.5 mg; 0.5 mg |
| 16 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.625 mg; 0.625 mg |
| 17 | Estradiol Estriol | Capsule | Estradiol; Estriol | 0.75 mg; 3 mg |
| 18 | Estradiol Estriol | Capsule | Estriol; Estradiol | 1.25 mg |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 19 | Estradiol Estriol | Capsule | Bi-Estrogen Oral Capsule: (Estriol/Estradiol) 60/40 or 70/30 or 80/20 | 1.25 mg; 2.5 mg |
| 20 | Estradiol Estriol | Capsule | Estradiol; Estriol | 1.5 mg; 1.5 mg |
| 21 | Estradiol Estriol | Capsule | Estriol; Estradiol | 2.5 mg |
| 22 | Estradiol Estriol | Capsule | Estriol; Estradiol | 5 mg |
| 23 | Estradiol Estriol | Cream | Bi-Est 50:50 (50% Estradiol, 50% Estriol) Cream | 0.25 mg; 0.5 mg; 0.75 mg; 1 mg |
| 24 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.1 mg/0.5 g; 0.1 mg/0.5 g |
| 25 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.1 mg/0.5 g; 0.1 mg/0.5 g |
| 26 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.1 mg/0.5 g; 0.1 mg/0.5 g |
| 27 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.1 mg/1 mL; 0.4 mg/1 mL |
| 28 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.125 mg/1 mL; 0.5 mg/1 mL |
| 29 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.15 mg/0.5 g; 0.15 mg/0.5 g |
| 30 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.2 mg/1 mL; 0.8 mg/1 mL |
| 31 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.25 mg/1 mL; 0.25 mg/1 mL |
| 32 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.25 mg/1 mL; 1 mg/1 mL |
| 33 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.375 mg/1 mL; 0.375 mg/1 mL |
| 34 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.4 mg/1 g; 0.4 mg/1 g |
| 35 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.4 mg/1 mL; 0.4 mg/1 mL |
| 36 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.4 mg/1 mL; 1.6 mg/1 mL |
| 37 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.5 mg/1 g; 2 mg/1 g |
| 38 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.5 mg/1 g; 2 mg/1 g |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 39 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.5 mg/1 g; 2.5 mg/1 g |
| 40 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.5 mg/1 mL; 0.5 mg/1 mL |
| 41 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.5 mg/1 mL; 2 mg/1 mL |
| 42 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.6 mg/1 mL; 0.6 mg/1 mL |
| 43 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.8 mg/1 mL; 0.8 mg/1 mL |
| 44 | Estradiol Estriol | Cream | Estradiol; Estriol | 0.8 mg/1 mL; 3.2 mg/1 mL |
| 45 | Estradiol Estriol | Cream | Estradiol; Estriol | 1 mg/1 mL; 1 mg/1 mL |
| 46 | Estradiol Estriol | Cream | Estradiol; Estriol | 1 mg/1 mL; 4 mg/1 mL |
| 47 | Estradiol Estriol | Cream | Estradiol; Estriol | 1.2 mg/1 mL; 1.2 mg/1 mL |
| 48 | Estradiol Estriol | Cream | Estradiol; Estriol | 1.25 mg/1 mL; 1.25 mg/1 mL |
| 49 | Estradiol Estriol | Cream | Bi-Estrogen Cream: (Estriol/Estradiol) 50/50 or 60/40 or 70/30 or 80/20 | 1.25 mg/0.1 mL; 2.5 mg/0.1 mL |
| 50 | Estradiol Estriol | Cream | Estradiol; Estriol | 1.5 mg/1 mL; 3.5 mg/1 mL |
| 51 | Estradiol Estriol | Cream | Estradiol; Estriol | 2 mg/1 g; 3 mg/1 g |
| 52 | Estradiol Estriol | Cream | Estradiol; Estriol | 2 mg/1 mL; 2 mg/1 mL |
| 53 | Estradiol Estriol | Cream | Estriol; Estradiol | 2 mg/g; 0.5 mg/g |
| 54 | Estradiol Estriol | Cream | Estradiol; Estriol | 2.5 mg/1 mL; 2.5 mg/1 mL |
| 55 | Estradiol Estriol | Cream | Estradiol; Estriol | 3 mg/1 mL; 2 mg/1 mL |
| 56 | Estradiol Estriol | Cream | Estradiol; Estriol | 5 mg/1 mL; 5 mg/1 mL |
| 57 | Estradiol Estriol | Cream | Estradiol; Estriol | 6.25 mg/1 mL; 6.25 mg/1 mL |
| 58 | Estradiol Estriol | Gel | Estradiol; Estriol | 1.25 mg/1 mL; 1.25 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 59 | Estradiol Estriol | Gel | Estriol; Estradiol | 2 mg/mL; 0.5 mg/mL |
| 60 | Estradiol Estriol | Lozenge | Estriol; Estradiol | 0.3125 mg; 0.9375 mg |
| 61 | Estradiol Estriol | Lozenge | Estriol; Estradiol | 0.5 mg; 0.125 mg |
| 62 | Estradiol Estriol | Lozenge | Estriol; Estradiol | 0.6 mg; 0.15 mg |
| 63 | Estradiol Estriol | Ointment | Estradiol; Estriol | 0.5 mg/1 g; 2 mg/1 g |
| 64 | Estradiol Estriol | Ointment | Estradiol; Estriol | 0.5 mg/1 g; 2 mg/1 g |
| 65 | Estradiol Estriol | Ointment | Estradiol; Estriol | 1 mg/1 g; 1.5 mg/1 g |
| 66 | Estradiol Estriol | Solution | Estradiol; Estriol | 1.25 mg/1 mL; 1.25 mg/1 mL |
| 67 | Estradiol Estriol | Solution | Estradiol; Estriol | 2 mg/1 mL; 8 mg/1 mL |
| 68 | Estradiol Estriol | Solution | Estriol; Estradiol | 2 mg; 0.25 mg/mL |
| 69 | Estradiol Testosterone | Cream | Estradiol; Testosterone | 0.3 mg/1 mL; 1 mg/1 mL |
| 70 | Estradiol Testosterone | Cream | Estradiol; Testosterone | 0.3 mg/1 mL; 1 mg/1 mL |
| 71 | Estradiol Testosterone | Cream | Estradiol; Testosterone | 0.4 mg/1 mL; 2 mg/1 mL |
| 72 | Estradiol Testosterone | Cream | Estradiol; Testosterone | 0.5 mg/1 mL; 0.75 mg/1 mL |
| 73 | Estradiol Testosterone | Ointment | Estradiol; Testosterone | 0.3 mg/1 g; 0.1 mg/1 g |
| 74 | Estradiol Testosterone | Ointment | Estradiol; Testosterone | 0.3 mg/1 g; 1 mg/1 g |
| 75 | Estradiol Testosterone | Ointment | Estradiol; Testosterone | 1 mg/1 g; 0.5 mg/1 g |
| 76 | Estriol Progesterone | Cream | Progesterone; Estriol | 25 mg/1 g; 3 mg/1 g |
| 77 | Estriol Testosterone | Cream | Testosterone; Estriol | 0.5 mg/1 g; 2 mg/1 g |
| 78 | Estriol Testosterone | Cream | Estriol; Testosterone | 1 mg/1 g; 3 mg/1 g |
| 79 | Estriol Testosterone | Cream | Estriol; Testosterone | 1 mg/1 g; 3 mg/1 g |
| 80 | Estriol Testosterone | Cream | Estriol; Testosterone; Desonide | 10 mg/1 g; 2.5 mg/1 g; 0.5 mg/1 g |
| 81 | Estriol Testosterone | Cream | Testosterone; Estriol | 4 mg/1 g; 6 mg/1 g |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 82 | Estriol Testosterone | Gel | Testosterone; Estriol | 0.25 mg/1 g; 0.5 mg/1 g |
| 83 | Estriol Testosterone | Gel | Estriol; Testosterone | 0.25 mg/1 mL; 2 mg/1 mL |
| 84 | Estriol Testosterone | Ointment | Lidocaine Hydrochloride; Testosterone; Estriol | 50 mg/1 g; 0.5 mg/1 g; 2.5 mg/1 g |
| 85 | Estriol Testosterone | Suppository | Estriol; Testosterone | 2 mg; 0.5 mg |
| 86 | Pregnenolone Progesterone | Cream | Progesterone; Pregnenolone | 150 mg/1 mL; 5 mg/1 mL |
| 87 | Progesterone Testosterone | Capsule | Progesterone; Methyltestosterone | 100 mg; 1.25 mg |
| 88 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 2 mg/1 g; 100 mg/1 g |
| 89 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 2 mg/1 g; 200 mg/1 g |
| 90 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 2 mg/1 g; 50 mg/1 g |
| 91 | Progesterone Testosterone | Cream | Progesterone; Testosterone | 20 mg/0.5 g; 1.25 mg/0.5 g |
| 92 | Progesterone Testosterone | Cream | Progesterone; Testosterone | 225 mg/1 mL; 0.5 mg/1 mL |
| 93 | Progesterone Testosterone | Cream | Progesterone; Testosterone | 30 mg/1 mL; 0.25 mg/1 mL |
| 94 | Progesterone Testosterone | Cream | Progesterone; Testosterone | 30 mg/1 mL; 2 mg/1 mL |
| 95 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 4 mg/1 g; 200 mg/1 g |
| 96 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 4 mg/1 g; 50 mg/1 g |
| 97 | Progesterone Testosterone | Cream | Testosterone; Progesterone | 4 mg/1 g; 70 mg/1 g |
| 98 | Testosterone Cypionate; Testosterone Propionate | Injection | Testosterone Cypionate; Testosterone Propionate | 160 mg/200 mg; 40 mg/200 mg |
| 99 | Testosterone Cypionate; Testosterone Propionate | Injection | Testosterone Propionate; Testosterone Cypionate | 20 mg/1 mL; 200 mg/1 mL |
| 100 | Testosterone Cypionate; Testosterone Propionate | Injection | Testosterone Propionate; Testosterone Cypionate | 20 mg/1 mL; 200 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 101 | Dehydroepiandrosterone; Estradiol; Estriol | Cream | Estriol; Estradiol; 7-Keto-Dehydroepiandrosterone | 1.25 mg/1 mL; 1.25 mg/1 mL; 20 mg/1 mL |
| 102 | Dehydroepiandrosterone; Estriol; Progesterone | Lozenge | Estriol; Progesterone; 7-Keto-Dehydroepiandrosterone | 1 mg; 10 mg; 10 mg |
| 103 | Dehydroepiandrosterone; Estriol; Progesterone | Lozenge | Estriol; Progesterone; 7-Keto-Dehydroepiandrosterone | 1 mg; 15 mg; 10 mg |
| 104 | Dehydroepiandrosterone; Pregnenolone; Progesterone | Capsule | Progesterone; Dehydroepiandrosterone Sodium Sulfate Anhydrous; Pregnenolone | 100 mg; 10 mg; 10 mg |
| 105 | Dehydroepiandrosterone; Pregnenolone; Progesterone | Cream | Progesterone; Pregnenolone; Dehydroepiandrosterone | 125 mg/1 mL; 10 mg/1 mL; 10 mg/1 mL |
| 106 | Dehydroepiandrosterone; Pregnenolone; Progesterone | Cream | Dehydroepiandrosterone; Progesterone; Pregnenolone | 5 mg/1 mL; 100 mg/1 mL; 10 mg/1 mL |
| 107 | Dehydroepiandrosterone; Progesterone; Testosterone | Cream | 7-Keto-Dehydroepiandrosterone; Testosterone; Progesterone | 2 mg/1 g; 1 mg/1 g; 160 mg/1 g |
| 108 | Estradiol; Progesterone; Testosterone | Capsule | Progesterone; Estradiol, Testosterone | |
| 109 | Estradiol; Progesterone; Testosterone | Capsule | Estradiol; Methyltestosterone; Progesterone | 0.85 mg; 1.5 mg; 175 mg |
| 110 | Estradiol; Progesterone; Testosterone | Capsule | Estradiol; Progesterone; Methyltestosterone | 1.1 mg; 165 mg; 1 mg |
| 111 | Estradiol; Progesterone; Testosterone | Capsule | Estradiol; Methyltestosterone; Progesterone | 1.3 mg; 2.75 mg; 160 mg |
| 112 | Estradiol; Progesterone; Testosterone | Capsule | Estradiol; Methyltestosterone; Progesterone | 1.9 mg; 1 mg; 170 mg |
| 113 | Estradiol; Progesterone; Testosterone | Cream | Estradiol; Testosterone; Progesterone | 0.4 mg/1 mL; 2.2 mg/1 mL; 85 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 114 | Estradiol; Progesterone; Testosterone | Cream | Estradiol; Testosterone; Progesterone | 0.55 mg/1 mL; 1.5 mg/1 mL; 95 mg/1 mL |
| 115 | Estradiol; Progesterone; Testosterone | Cream | Estradiol; Testosterone; Progesterone | 0.65 mg/1 mL; 1.5 mg/1 mL; 125 mg/1 mL |
| 116 | Estradiol; Progesterone; Testosterone | Cream | Estradiol; Testosterone; Progesterone | 0.7 mg/1 mL; 1.5 mg/1 mL; 135 mg/1 mL |
| 117 | Estradiol; Progesterone; Testosterone | Cream | Estradiol; Testosterone; Progesterone | 2 mg/1 mL; 0.5 mg/1 mL; 125 mg/1 mL |
| 118 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 0.25 mg; 2 mg; 0.25 mg |
| 119 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 2.5 mg |
| 120 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 2.5 mg |
| 121 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 2.5 mg |
| 122 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 2.5 mg |
| 123 | Estradiol Estriol; Estrone | Capsule | Estradiol; Estriol; Estrone | 2.5 mg |
| 124 | Estradiol Estriol; Estrone | Cream | Estradiol; Estriol; Estrone | 0.25 mg/g; 2 mg/g; 0.25 mg/g |
| 125 | Estradiol Estriol; Estrone | Cream | Estriol; Estradiol; Estrone | 10 mg/1 mL; 1.25 mg/1 mL; 1.25 mg/1 mL |
| 126 | Estradiol Estriol; Estrone | Gel | Estradiol; Estriol; Estrone | 2.5 mg/0.1 mL |
| 127 | Estradiol Estriol; Estrone | Injection | Estradiol; Estriol; Estrone | 2.5 mg/mL |
| 128 | Estradiol Estriol; Estrone | Solution | Estradiol; Estriol; Estrone | 0.25 mg/mL; 2 mg/mL; 0.25 mg/mL |
| 129 | Estradiol Estriol; Estrone | Solution | Estradiol; Estriol; Estrone | 2.5 mg/0.1 mL |
| 130 | Estradiol Estriol; Estrone | Tablet | Estradiol; Estriol; Estrone | 2.5 mg |
| 131 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.05 mg; 125 mg; 0.45 mg |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 132 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.06 mg; 100 mg; 0.24 mg |
| 133 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.06 mg; 125 mg; 0.24 mg |
| 134 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.08 mg; 100 mg; 0.32 mg |
| 135 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.1 mg; 100 mg; 0.1 mg |
| 136 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.1 mg; 70 mg; 0.4 mg |
| 137 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.12 mg; 50 mg; 0.28 mg |
| 138 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.15 mg; 80 mg; 0.15 mg |
| 139 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.16 mg; 50 mg; 0.64 mg |
| 140 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.25 mg; 50 mg; 1 mg |
| 141 | Estradiol Estriol; Progesterone | Capsule | Estriol; Estradiol; Progesterone | 0.32 mg; 0.08 mg; 125 mg |
| 142 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.5 mg; 120 mg; 0.5 mg |
| 143 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 0.5 mg; 125 mg; 0.5 mg |
| 144 | Estradiol Estriol; Progesterone | Capsule | Estradiol; Progesterone; Estriol | 1.15 mg; 175 mg; 1.15 mg |
| 145 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 0.08 mg/1 mL; 10 mg/1 mL; 0.32 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 146 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 0.08 mg/1 mL; 30 mg/1 mL; 0.32 mg/1 mL |
| 147 | Estradiol Estriol; Progesterone | Cream | Estriol; Estradiol; Progesterone | 0.1 mg/1 mL; 0.1 mg/1 mL; 40 mg/1 mL |
| 148 | Estradiol Estriol; Progesterone | Cream | Estriol; Estradiol; Progesterone | 0.25 mg/1 mL; 0.25 mg/1 mL; 25 mg/1 mL |
| 149 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 0.25 mg/1 mL; 200 mg/1 mL; 0.25 mg/1 mL |
| 150 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 0.25 mg/1 mL; 25 mg/1 mL; 0.25 mg/1 mL |
| 151 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 0.5 mg/1 g; 200 mg/1 g; 0.5 mg/1 g |
| 152 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 0.5 mg/1 g; 200 mg/1 g; 0.5 mg/1 g |
| 153 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 0.5 mg/1 g; 40 mg/1 g; 0.5 mg/1 g |
| 154 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 0.5 mg/1 mL; 30 mg/1 mL; 0.5 mg/1 mL |
| 155 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 0.8 mg/1 g; 20 mg/1 g; 0.2 mg/1 g |
| 156 | Estradiol Estriol; Progesterone | Cream | Estriol, Estradiol; Progesterone | 0.2%; 0.2%; 12.5% |
| 157 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 100 mg/1 g; 1 mg/1 g |
| 158 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 100 mg/1 g; 1 mg/1 g |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 159 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 100 mg/1 g; 1 mg/1 g |
| 160 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 200 mg/1 g; 1 mg/1 g |
| 161 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 40 mg/1 g; 0.25 mg/1 g |
| 162 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 1 mg/1 g; 50 mg/1 g; 1 mg/1 g |
| 163 | Estradiol Estriol; Progesterone | Cream | Estriol; Estradiol; Progesterone | 1 mg/1 mL; 0.25 mg/1 mL; 100 mg/1 mL |
| 164 | Estradiol Estriol; Progesterone | Cream | Estriol; Progesterone; Estradiol | 2 mg/1 g; 160 mg/1 g; 2 mg/1 g |
| 165 | Estradiol Estriol; Progesterone | Cream | Estradiol; Progesterone; Estriol | 2.5 mg/1 mL; 50 mg/1 mL; 2.5 mg/1 mL |
| 166 | Estradiol Estriol; Progesterone | Cream | Progesterone; Estriol; Estradiol | 20 mg/0.5 g; 0.1 mg/0.5 g; 0.1 mg/0.5 g |
| 167 | Estradiol Estriol; Progesterone | Cream | Progesterone; Estriol; Estradiol | 20 mg/1 mL; 0.2 mg/1 mL; 0.05 mg/1 mL |
| 168 | Estradiol Estriol; Progesterone | Lozenge | Estradiol; Progesterone; Estriol | 0.16 mg; 200 mg; 0.64 mg |
| 169 | Estradiol Estriol; Progesterone | Lozenge | Estradiol; Progesterone; Estriol | 2.8 mg; 120 mg; 11.2 mg |
| 170 | Estradiol Estriol; Progesterone | Lozenge | Progesterone; Estriol; Estradiol | 25 mg; 2.4 mg; 0.6 mg |
| 171 | Estradiol Estriol; Progesterone | Lozenge | Progesterone; Estriol; Estradiol | 30 mg; 1.6 mg; 0.4 mg |
| 172 | Estradiol Estriol; Progesterone | Lozenge | Progesterone; Estriol; Estradiol | 30 mg; 2 mg; 0.5 mg |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 173 | Estradiol Estriol; Testosterone | Cream | Estriol; Estradiol; Testosterone | 0.2 mg/0.5 g; 0.2 mg/0.5 g; 1 mg/0.5 g |
| 174 | Estradiol Estriol; Testosterone | Cream | Estriol; Estradiol; Testosterone | 0.25 mg/1 mL; 0.25 mg/1 mL; 2 mg/1 mL |
| 175 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 0.25 mg/1 mL; 0.5 mg/1 mL; 1 mg/1 mL |
| 176 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 0.3 mg/1 mL; 1 mg/1 mL; 1.2 mg/1 mL |
| 177 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 0.5 mg/1 mL; 0.5 mg/1 mL; 0.5 mg/1 mL |
| 178 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 0.5 mg/1 mL; 1 mg/1 mL; 0.5 mg/1 mL |
| 179 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 0.5 mg/1 mL; 1.5 mg/1 mL; 0.5 mg/1 mL |
| 180 | Estradiol Estriol; Testosterone | Cream | Estriol; Estradiol; Testosterone | 1 mg/1 g; 1 mg/1 g; 2 mg/1 g |
| 181 | Estradiol Estriol; Testosterone | Cream | Estriol; Estradiol; Testosterone | 1 mg/1 g; 1 mg/1 g; 4 mg/1 g |
| 182 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 1 mg/1 mL; 1 mg/1 mL; 1 mg/1 mL |
| 183 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 1 mg/1 mL; 3 mg/1 mL; 1 mg/1 mL |
| 184 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 2 mg/1 mL; 1 mg/1 mL; 8 mg/1 mL |
| 185 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 2 mg/1 mL; 1.5 mg/1 mL; 2 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 186 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 3 mg/1 mL; 4 mg/1 mL; 3 mg/1 mL |
| 187 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 3.75 mg/1 mL; 2.5 mg/1 mL; 3.75 mg/1 mL |
| 188 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 4 mg/1 mL; 6 mg/1 mL; 4 mg/1 mL |
| 189 | Estradiol Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol | 5 mg/1 mL; 2.5 mg/1 mL; 5 mg/1 mL |
| 190 | Estriol; Progesterone; Testosterone | Cream | Testosterone; Estriol; Progesterone | 4 mg/1 g; 6 mg/1 g; 100 mg/1 g |
| 191 | Dehydroepiandrosterone; Estradiol; Progesterone; Testosterone | Capsule | Estradiol; Methyltestosterone; Progesterone; Dehydroepiandrosterone | 0.75 mg; 1.5 mg; 150 mg; 7.5 mg |
| 192 | Dehydroepiandrosterone; Estradiol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Dehydroepiandrosterone | 0.35 mg/1 mL; 150 mg/1 mL; 1.9 mg/1 mL; 7 mg/1 mL |
| 193 | Dehydroepiandrosterone; Estradiol; Estriol; Progesterone | Capsule | Estradiol; Progesterone; Dehydroepiandrosterone; Estriol | 0.85 mg; 95 mg; 5 mg; 0.35 mg |
| 194 | Dehydroepiandrosterone; Estradiol; Estriol; Progesterone | Cream | Estriol; Estradiol; Progesterone; 7-Keto-Dehydroepiandrosterone | 0.05 mg/1 mL; 0.05 mg/1 mL; 15 mg/1 mL; 6 mg/1 mL |
| 195 | Dehydroepiandrosterone; Estradiol; Estriol; Progesterone | Cream | Estradiol; Progesterone; Dehydroepiandrosterone; Estriol | 0.12 mg/1 mL; 40 mg/1 mL; 2 mg/1 mL; 0.48 mg/1 mL |
| 196 | Dehydroepiandrosterone; Estradiol; Estriol; Progesterone | Cream | Estriol; Estradiol; 7-Keto-Dehydroepiandrosterone; Progesterone | 0.7 mg/1 mL; 0.3 mg/1 mL; 5 mg/1 mL; 40 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 197 | Dehydroepiandrosterone; Estradiol; Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol; Dehydroepiandrosterone | 0.225 mg/1 mL; 1.5 mg/1 mL; 0.225 mg/1 mL; 5 mg/1 mL |
| 198 | Dehydroepiandrosterone; Estradiol; Estriol; Testosterone | Cream | Estradiol; Testosterone; Estriol; Dehydroepiandrosterone | 0.225 mg/1 mL; 3 mg/1 mL; 0.225 mg/1 mL; 5 mg/1 mL |
| 199 | Dehydroepiandrosterone; Estradiol; Estriol; Testosterone | Cream | Estriol; Estradiol; Testosterone; 7-Keto-Dehydroepiandrosterone | 1.25 mg/1 mL; 1.25 mg/1 mL; 4 mg/1 mL; 20 mg/1 mL |
| 200 | Estradiol; Estriol; Estrone; Progesterone | Capsule | Estradiol; Progesterone; Estriol; Estrone | 0.125 mg; 50 mg; 1 mg; 0.125 mg |
| 201 | Estradiol; Estriol; Progesterone; Testosterone | Capsule | Estradiol; Progesterone; Testosterone; Estriol | 0.1 mg; 150 mg; 2 mg; 0.4 mg |
| 202 | Estradiol; Estriol; Progesterone; Testosterone | Capsule | Estriol; Estradiol; Progesterone; Testosterone | 2.5 mg; 50 mg; 1 mg |
| 203 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.02 mg/1 mL; 125 mg/1 mL; 2 mg/1 mL; 0.08 mg/1 mL |
| 204 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.08 mg/1 mL; 20 mg/1 mL; 1 mg/1 mL; 0.32 mg/1 mL |
| 205 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.15 mg/1 mL; 100 mg/1 mL; 4 mg/1 mL; 0.35 mg/1 mL |
| 206 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.2 mg/1 mL; 150 mg/1 mL; 0.5 mg/1 mL; 0.8 mg/1 mL |
| 207 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.2 mg/1 mL; 30 mg/1 mL; 0.5 mg/1 mL; 0.3 mg/1 mL |
| 208 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.25 mg/1 mL; 30 mg/1 mL; 1 mg/1 mL; 0.25 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 209 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.3 mg/1 mL; 25 mg/1 mL; 0.25 mg/1 mL; 1 mg/1 mL |
| 210 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.3 mg/1 mL; 40 mg/1 mL; 1 mg/1 mL; 0.3 mg/1 mL |
| 211 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.4 mg/1 mL; 200 mg/1 mL; 0.5 mg/1 mL; 1.6 mg/1 mL |
| 212 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.4 mg/1 mL; 200 mg/1 mL; 2 mg/1 mL; 1.6 mg/1 mL |
| 213 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 100 mg/1 g; 1 mg/1 g |
| 214 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 100 mg/1 g; 2 mg/1 g |
| 215 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 100 mg/1 g; 2 mg/1 g |
| 216 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 150 mg/1 g; 2 mg/1 g |
| 217 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 200 mg/1 g; 2 mg/1 g |
| 218 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 200 mg/1 g; 2 mg/1 g |
| 219 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 50 mg/1 g; 2 mg/1 g |
| 220 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.5 mg/1 g; 0.5 mg/1 g; 80 mg/1 g; 3 mg/1 g |
| 221 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Testosterone; Progesterone | 0.5 mg/1 mL; 0.5 mg/1 mL; 0.5 mg/1 mL; 60 mg/1 mL |
| 222 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Testosterone; Progesterone | 0.5 mg/1 mL; 0.5 mg/1 mL; 0.5 mg/1 mL; 60 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 223 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.5 mg/1 mL; 100 mg/1 mL; 1 mg/1 mL; 2 mg/1 mL |
| 224 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.5 mg/1 mL; 20 mg/1 mL; 0.5 mg/1 mL; 0.5 mg/1 mL |
| 225 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.5 mg/1 mL; 20 mg/1 mL; 1 mg/1 mL; 0.5 mg/1 mL |
| 226 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 0.6 mg/1 mL; 100 mg/1 mL; 1 mg/1 mL; 2.4 mg/1 mL |
| 227 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.8 mg/1 g; 0.2 mg/1 g; 50 mg/1 g; 1 mg/1 g |
| 228 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 0.875 mg/1 g; 0.875 mg/1 g; 50 mg/1 g; 5 mg/1 g |
| 229 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Testosterone; Estriol; Estradiol; Progesterone | 1 mg/1 g; 0.5 mg/1 g; 0.5 mg/1 g; 60 mg/1 g |
| 230 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 100 mg/1 g; 1 mg/1 g |
| 231 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 100 mg/1 g; 1 mg/1 g |
| 232 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 100 mg/1 g; 2 mg/1 g |
| 233 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 100 mg/1 g; 2 mg/1 g |
| 234 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 100 mg/1 g; 2 mg/1 g |
| 235 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 150 mg/1 g; 1 mg/1 g |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 236 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 150 mg/1 g; 2 mg/1 g |
| 237 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 150 mg/1 g; 2 mg/1 g |
| 238 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 150 mg/1 g; 2 mg/1 g |
| 239 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 200 mg/1 g; 2 mg/1 g |
| 240 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 50 mg/1 g; 1 mg/1 g |
| 241 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 1 mg/1 g; 1 mg/1 g; 60 mg/1 g; 2 mg/1 g |
| 242 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Testosterone; Estradiol; Progesterone; Estriol | 1 mg/1 mL; 0.2 mg/1 mL; 30 mg/1 mL; 0.2 mg/1 mL |
| 243 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 1 mg/1 mL; 50 mg/1 mL; 4 mg/1 mL; 1 mg/1 mL |
| 244 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 1 mg/1 mL; 50 mg/1 mL; 8 mg/1 mL; 1 mg/1 mL |
| 245 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 2 mg/1 g; 2 mg/1 g; 120 mg/1 g; 4 mg/1 g |
| 246 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 2 mg/1 g; 2 mg/1 g; 200 mg/1 g; 2 mg/1 g |
| 247 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone | 2 mg/1 g; 2 mg/1 g; 50 mg/1 g; 4 mg/1 g |
| 248 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol | 2 mg/1 mL; 120 mg/1 mL; 2 mg/1 mL; 2 mg/1 mL |
| 249 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Progesterone; Estriol; Estradiol; Testosterone | 20 mg/0.5 g; 0.1 mg/0.5 g; 0.1 mg/0.5 g; 2 mg/0.5 g |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| No. | Active Ingredients Present from Listinga | Dosage Form | All Reported Active Ingredients | All Reported Active Ingredient Strengthsb |
|---|---|---|---|---|
| 250 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Progesterone; Estriol; Estradiol; Testosterone | 20 mg/0.5 g; 0.15 mg/0.5 g; 0.15 mg/0.5 g; 2 mg/0.5 g |
| 251 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Testosterone; Progesterone | 3 mg/1 mL; 1 mg/1 mL; 1 mg/1 mL; 25 mg/1 mL |
| 252 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Progesterone; Estriol; Estradiol; Testosterone | 35 mg/0.5 g; 0.25 mg/0.5 g; 0.25 mg/0.5 g; 2 mg/0.5 g |
| 253 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Progesterone; Estriol; Estradiol; Testosterone | 50 mg/0.5 g; 0.3 mg/0.5 g; 0.3 mg/0.5 g; 1.5 mg/0.5 g |
| 254 | Estradiol; Estriol; Progesterone; Testosterone | Cream | Progesterone; Estriol; Estradiol; Testosterone | 80 mg/0.5 g; 0.25 mg/0.5 g; 0.25 mg/0.5 g; 0.25 mg/0.5 g |
| 255 | Estradiol; Estriol; Progesterone; Testosterone | Solution | Estradiol; Progesterone; Testosterone; Estriol | 0.5 mg/1 mL; 100 mg/1 mL; 2 mg/1 mL; 2 mg/1 mL |
| 256 | Estradiol; Estriol; Pregnenolone; Progesterone | Cream | Estriol; Estradiol; Progesterone; Pregnenolone | 2 mg/1 g; 2 mg/1 g; 40 mg/1 g; 50 mg/1 g |
| 257 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Capsule | Estriol; Estradiol; Dehydroepiandrosterone; Methyltestosterone; Progesterone | 5.25 mg; 1.5 mg; 5 mg; 4 mg; 190 mg |
| 258 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estriol; Dehydroepiandrosterone; Estradiol; Progesterone; Testosterone | 0.14 mg/1 mL; 4 mg/1 mL; 0.06 mg/1 mL; 40 mg/1 mL; 1 mg/1 mL |
| 259 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol; Dehydroepiandrosterone | 0.15 mg/1 mL; 20 mg/1 mL; 4 mg/1 mL; 0.15 mg/1 mL; 10 mg/1 mL |
| 260 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol; Dehydroepiandrosterone | 0.35 mg/1 mL; 85 mg/1 mL; 0.35 mg/1 mL; 0.35 mg/1 mL; 5 mg/1 mL |
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
| 261 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estriol; Estradiol; Progesterone; Testosterone; Dehydroepiandrosterone | 0.75 mg/1 mL; 0.25 mg/1 mL; 20 mg/1 mL; 0.5 mg/1 mL; 5 mg/1 mL |
| 262 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Dehydroepiandrosterone; Estriol | 3.75 mg/1 mL; 75 mg/1 mL; 2 mg/1 mL; 10 mg/1 mL; 2.5 mg/1 mL |
| 263 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Cream | Estradiol; Progesterone; Testosterone; Estriol; Dehydroepiandrosterone | 4 mg/1 mL; 75 mg/1 mL; 2.5 mg/1 mL; 3 mg/1 mL; 15 mg/1 mL |
| 264 | Dehydroepiandrosterone; Estradiol Estriol; Progesterone; Testosterone | Gel | Estriol; Dehydroepiandrosterone; Estradiol; Progesterone; Testosterone | 3 mg/1 mL; 30 mg/1 mL; 1.2 mg/1 mL; 50 mg/1 mL; 2 mg/1 mL |
| 265 | Estradiol Estriol; Estrone Progesterone; Testosterone | Capsule | Estradiol; Estriol; Estrone; Progesterone; Testosterone | 2.5 mg; 100 mg; 1 mg |
| 266 | Estradiol Estriol; Estrone Progesterone; Testosterone | Cream | Estradiol; Estriol; Estrone; Progesterone; Testosterone |
a Under “Active Ingredient Present from Listing” for combination products, methyltestosterone and testosterone enanthate are categorized as testosterone, and 7-keto-dehydroepiandrosterone as dehydroepiandrosterone.
b Under “All Reported Active Ingredient Strengths,” if field is blank, ingredient strengths and/or units were not reported.
NOTE: Resources included peer-reviewed literature on use of cBHT (e.g., IJPC, 2018), cBHT preparation adverse event reports (FDA, 2018, 2020), information provided by compounding practitioners (see the National Academies Public Access File), recent biannual outsourcing facility preparation reports (FDA, 2019), and online marketing information from compounding pharmacies.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
REFERENCES
FDA (U.S. Food and Drug Administration). 2018. MedWatch. https://www.fda.gov/safety/medwatch-fda-safety-information-and-adverse-event-reporting-program (accessed June 3, 2020).
FDA. 2019. Email from G. Cosel to National Academies staff regarding aggregated volume output of products containing ingredients of interest to compounded bioidentical hormone therapy study. May 30, 2020 (available through the National Academies Public Access File).
FDA. 2020. Compounding: Inspections, recalls, and other actions. https://www.fda.gov/drugs/human-drug-compounding/compounding-inspections-recalls-and-other-actions (accessed January 13, 2020).
IJPC (International Journal of Pharmaceutical Compounding). 2018. Compounding for bioidentical hormone replacement therapy patients. Purchased compiled peer-reviewed articles from 1997–2018. In IJPC. Edmond, OK: IJPC.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
Suggested Citation:
"Appendix G: Compounded Bioidentical Hormone Therapy Formulations with Two or More Active Ingredients." National Academies of Sciences, Engineering, and Medicine. 2020. The Clinical Utility of Compounded Bioidentical Hormone Therapy: A Review of Safety, Effectiveness, and Use. Washington, DC: The National Academies Press.
doi: 10.17226/25791.
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