| AAAS | American Academy of Arts and Sciences |
| AAPI | Asian American and Pacific Islander |
| ABS | acrylonitrile butadiene styrene |
| ACE | advanced colloids experiment |
| ACME | advanced combustion microgravity experiment |
| AFM | atomic force microscopy |
| AFRL | Air Force Research Laboratory |
| AHA2 | Arabidopsis plasma membrane proton APTase 2 |
| AI | artificial intelligence |
| ALS | advanced life support |
| ALSDA | animal life sciences data archive |
| AM | additive manufacturing |
| AMF | ISS Additive Manufacturing Facility |
| AMO | atomic, molecular, and optical (physics) |
| AMR | anti-microbial resistance |
| AOX | alternative oxidase |
| APH | Advanced Plant Habitat |
| ASEP | advanced space experiment processor |
| ATP | adenosine triphosphate |
| AWG | Analysis Working Group (GeneLab) |
| BASS | Burning and Supression of Solids (NASA) |
| BBB | blood-brain barrier |
| BCAT | binary colloidal aggregation test |
| BEC | Bose-Einstein condensate |
| BFF | BioFabrication Facility |
| BGC | biosynthetic gene cluster |
| BiPS-Free | Biological and Physical Science Free Flyer |
| BLEO | beyond LEO |
| BLiSS | Bioregenerative Life Support Systems |
| BPAC | Biological and Physical Advisory Committee |
| BPS | biological and physical sciences |
| BPS Division | Division of Biological and Physical Sciences (NASA) |
| BRIC | Biological Research in Canister |
| BSM | beyond standard model |
| BSP | Biospecimen Sharing Program |
| CACES | Cold Atom Clock Experiment in Space (China) |
| CAL | Cold Atom Laboratory |
| CASIS | Center for the Advancement of Science in Space |
| CBEF | Cell Biology Equipment Facility (JAXA) |
| CBPSS | Committee on Biological and Physical Space Sciences |
| CERISS | Commercially Enabled Rapid Space Science Initiative |
| CESA1 | cellulose synthase 1 |
| CESI-MS | capillary electrospray ionization |
| CFD | computational fluid dynamics |
| CFM | cryogenic fluid management |
| CheX | confined helium experiment |
| CHF | critical heat flux |
| CI | computational infrastructure |
| CIR | Combustion Integrated Rack |
| CLD | coflow laminar diffusion |
| CLD | Commercial LEO Destination |
| CLPS | commercial lunar payload services (NASA) |
| CM-HT | flow condensation module for heat transfer measurements |
| CNS | central nervous system |
| COTS | commercial off-the-shelf |
| CPU | computer processing unit |
| CRISPR | Clustered Regularly Interspaced Short Palindromic Repeats |
| CSA | Canadian Space Agency |
| CSF | cerebrospinal fluid |
| CSK | cytoskeleton |
| CTE | coefficient of thermal expansion |
| CubeSat | cube-satellite |
| DARPA | Defense Advanced Research Projects Agency |
| DEIA | diversity, equity, inclusion, and accessibility |
| DLR | German Space Agency |
| DNA | deoxyribonucleic acid |
| DoD | Department of Defense |
| DOE | Department of Energy |
| DOTT | Deep Space OTT |
| DSAC | deep space atomic clock |
| DYNAMX | science requirements document for the critical dynamics in microgravity |
| ECLSS | environmental control and life support system (ISS) |
| ECM | extracellular matrix |
| EEA | Erasmus Experiment Archive |
| EEF | ecology experiment facility |
| EGF | epidermal growth factor |
| ELF | Electrostatic Levitation Furnace (JAXA) |
| EMCS | European Modular Cultivation System |
| EMILI | European Molecular Indicator of Life |
| EML | ISS Electromagnetic Levitator (ESA) |
| EMU | extravehicular mobility unit |
| EPS | extracellular polymeric substance |
| ESA | European Space Agency |
| EV | extracellular vesicle |
| EVA | extravehicular activity |
| EXPRESS | Expedite the Processing of Experiments to Space Station |
| FAIR | findable, accessible, interoperable, and reusable |
| FBCE | flow boiling and condensation experiment |
| FBM | flow boiling module |
| FFE | far-from-equilibrium |
| FFI | fractional frequency instability |
| FLEX | flame extinguishment experiment |
| FPS | fission power system |
| FTIR | Fourier transformed infrared spectroscopy |
| GC | gas chromatography |
| GCR | galactic cosmic ray |
| GEM | graduate education for minority students |
| GEO | geostationary orbit |
| GPI | glycosylphosphatidylinositol |
| GPS | Global Positioning System |
| GSE | ground support equipment |
| GW | gravitational wave |
| HBCU | Historically Black College and University |
| HCCI | homogeneous charge compression ignition |
| HCU | Habitat Cage Unit (JAXA) |
| HEO | Human Exploration and Operations Mission Directorate (NASA) |
| HLS | human landing system (NASA) |
| HRP | Human Research Program (NASA) |
| HSF | heat shock factor |
| HSI | Hispanic-serving institution |
| HSP | heat shock protein |
| ICP | intracranial pressure |
| ISRU | in situ resource utilization |
| ISS | International Space Station |
| ISSNL | ISS National Laboratory |
| ISSPO | ISS Program Office |
| JAXA | Japan Aerospace Exploration Agency |
| JWST | James Webb Space Telescope |
| KSQ | key scientific question |
| LC | liquid chromatography |
| LEO | low Earth orbit |
| LGBTQ+ | lesbian, gay, bisexual, transgender, queer, + |
| LHC | Large Hadron Collider |
| LIGO | Laser Interferometer Gravitational-Wave Observatory |
| LINC | linker of nucleoskeleton and cytoskeleton |
| LISA | Laser Interferometer Space Antenna |
| LMM | Light Microscopy Module |
| LOI | limiting oxygen index |
| LOTT | LEO OTT |
| LPE | Lambda Point Experiment |
| LSDA | Life Sciences Data Archive |
| LTEE | long-term evolution experiment |
| M2TIC | micro-mercury trapped-ion clock |
| MAIUS | matter-wave interferometry in microgravity (DLR) |
| MATRICES | Manufacturing Materials and Processes for Sustainability in Space |
| MCS | multi-component search |
| MDCA | Multi-User Droplet Combustion Apparatus |
| ME-LIF | microchip electrophoresis laser induced fluorescence |
| MELiSSA | Micro-Ecological Life Support System Alternative (ESA) |
| MGCB | Microgravity Database |
| MI&O | ISSPO integration and operations costs |
| MICROSCOPE | Microsatellite à traînée compensée pour l’observation du principe d’equivalence |
| miRNA | micro-RNA |
| MISSE | materials international space station experiment |
| MISSE-FF | MISSE flight facility |
| MLE | mid-deck locker equivalent |
| MLOC | minimum limiting oxygen concentration |
| MoBE | microbes of the built environment |
| MOC | maximum oxygen concentration |
| mRNA | messenger RNA |
| MS | mass spectroscopy |
| MSG | microgravity science glovebox |
| MSI | minority-serving institution |
| mtDNA | mitochondrial DNA |
| MVP | Multi-Use Variable-G Platform |
| NADPH | nicotinamide adenine dinucleotide phosphate |
| NASA | National Aeronautics and Space Administration |
| NBISC | NASA Biological Institutional Scientific Collection |
| NCATS | National Center for Advancing Translational Sciences |
| NGO | non-government organization |
| NGS | next-generation sequencing |
| NIH | National Institutes of Health |
| NIST | National Institute of Standards and Technology |
| NMR | nuclear magnetic resonance |
| NO | nitric oxide |
| NSF | National Science Foundation |
| NSRL | NASA Space Radiation Laboratory |
| OECD | Organisation for Economic Co-operation and Development |
| OHALO | operational crop production system and prototype for a Mars transit vehicle |
| OLC | optical lattice clock |
| OTT | optical time transfer |
| PAESMEM | Presidential Award for Excellence in Science, Mathematics and Engineering Mentoring |
| PCE | Polymer and Composite Experiment |
| PCR | polymerase chain reaction |
| PE | polyethylene |
| PEC | Passive Experiment Container |
| PET | polyethylene terephthalate |
| PFaST | Probing the Fabric of Spacetime |
| PGP | Plant Gravity Perception |
| PGP | plant growth promoting |
| PHA | poly-hydroxy alkanoic acid |
| PHAB | plate habitat |
| PHB | poly-hydroxy butyrate |
| PRoMO | polar radiation of model organisms |
| PSI | Physical Science Informatics |
| QUESS | Quantum Experiments at Space Scale (China) |
| R&D | research and development |
| RCCI | reactivity-controlled compression ignition |
| RCLF | relevant civilian labor force |
| RNA | ribonucleic acid |
| ROS | reactive oxygen species |
| ROS | Russian Orbital Segment |
| ROSES | Research Opportunities in Earth and Space Program |
| RTI | Rayleigh-Taylor Instability |
| S&E | science and engineering |
| SABL | Space Automated Bioproduct Laboratory |
| SAMS | space acceleration measurement system |
| SANS | Spaceflight-Associated Neuro-Ocular Syndrome |
| SciAct | science activation |
| SEDI | socially or economically disadvantaged individual |
| SES | senior executive service |
| SHERE | shear history extensional rheology experiment |
| SL | senior level |
| SLPSRA | Division of Space Life and Physical Sciences Research and Application (NASA) |
| SM | standard model |
| SMD | Science Mission Directorate (NASA) |
| SMG | simulated microgravity |
| SOC | space optical clock |
| SoFIE | Solid Fuel Ignition and Extinction |
| SoT | statement of task |
| SOTT | space-to-space OTT |
| SPE | solar particle event |
| SSERVI | Solar System Exploration Research Institute (NASA) |
| STAR | spaceflight technology, applications, and research |
| STEM | science, technology, engineering, and mathematics |
| STMD | Space Technology Mission Directorate (NASA) |
| SWaP | size, weight, and power |
| SynCom | synthetic microbial community |
| TCA | tricarboxylic acid |
| TCS | thermal control system |
| TOAST | Test of Arabidopsis Space Transcriptome |
| TRACE | technical risk and cost evaluation |
| TRISH | Translational Institute for Space Health |
| TWOTFT | two-way optical time and frequency transfer |
| UHTC | ultra-high temperature ceramic |
| UNOOSA | United Nations Office for Outer Space Affairs |
| USDA | U.S. Department of Agriculture |
| USOS | U.S. Orbital Segment, portion of the International Space Station |
| UV | ultraviolet |
| VCC | vapor compression cycle |
| Veggie | ISS vegetable production system |
| VFB | Vented Fly Box |
| VLBI | very long-baseline interferometry |
| VOC | volatile organic compound |
| WIMP | weakly interacting massive particle |
| XRD | X-ray diffraction |
| ZBOT | zero boil-off tank |