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Oversight Unit

Physical Sciences, Systems, and Infrastructure Program Area

This program area sets research priorities, highlights critical future directions, and develops policy innovations to advance mathematical and physical sciences, energy systems, engineering and manufacturing, infrastructure and facilities, and defense and intelligence.

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News and Updates

How Innovation Could Reshape Chemistry by 2050

Feature Story

Chemistry and chemical engineering are fundamental to technologies that could revolutionize energy production, quantum computing, and materials and manufacturing over the coming decades. At a recent workshop, participants from academia, industry, and government considered the future of the chemical sciences, exploring scientific challenges that researchers should prioritize, where strategic investments could enable breakthroughs, and how the chemical sciences community can prepare for emerging capabilities.

Aug 27, 2026
Chemistry 2050: A Roadmap to the Future - A Workshop. August 6, 2026. At the Keck Center

Digital Overview: A Vision for the Manufacturing USA Program in 2030 and 2035

Announcement

American manufacturing is at a crossroads. A new National Academies' report examines how the Manufacturing USA program can be strengthened to meet the nation’s manufacturing challenges over the next decade and beyond. Find out more by exploring the digital overview.

May 14, 2026
Two Car Factory Specialists in High Visibility Vests Using Laptop Computer. Engineers Discussing Automotive Industrial Manufacturing Facility Process of Vehicle Production. Automated Assembly Plant.

DOE Should Develop AI-Based Foundation Models Fused with Traditional Computational Methods to Bring Paradigm Shift to Scientific Discovery

News Release

Foundation models are AI systems trained on vast amounts of data — often trillions of individual data points — and they are capable of learning new ways of modeling information and performing a range of tasks. A new National Academies report examines how the U.S. Department of Energy could use these models to potentially transform scientific discovery and innovation.

Dec 16, 2025
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Our Expertise

The Physical Sciences, Systems, and Infrastructure program area brings together leading experts from academia, government, and industry to provide independent and forward-thinking advice to support technology development and identify critical future research directions across the mathematical and physical sciences and engineering. Our work shapes policy and guides decision making on topics such as the future of U.S. energy systems, infrastructure needs, smart manufacturing, military force modernization, mission-focused Service systems integration, and defense applications for emerging technologies. 

Our landmark studies explore the opportunities and challenges at the frontiers of technology innovation — from digital twins to advanced nuclear reactors — and provide actionable advice on ways to harness these new advances for the benefit of the nation. Our workshops and roundtables offer unparalleled forums to discuss complex and timely issues as they arise with experts from across disciplines and perspectives. 

Statement of Task

Addresses innovations in physical sciences – math, physics, chemistry – with a systems approach across disciplines and domains including: Energy/Electricity, Manufacturing/Materials, and S&T for Defense/Intelligence.

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