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Oversight Unit

Physical Sciences, Systems, and Infrastructure Program Area

This program area sets research priorities, highlights critical future directions, and develops policy innovations to advance mathematical and physical sciences, energy systems, engineering and manufacturing, infrastructure and facilities, and defense and intelligence.

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News and Updates

Digital Overview: A Vision for the Manufacturing USA Program in 2030 and 2035

Announcement

American manufacturing is at a crossroads. A new National Academies' report examines how the Manufacturing USA program can be strengthened to meet the nation’s manufacturing challenges over the next decade and beyond. Find out more by exploring the digital overview.

May 14, 2026
Two Car Factory Specialists in High Visibility Vests Using Laptop Computer. Engineers Discussing Automotive Industrial Manufacturing Facility Process of Vehicle Production. Automated Assembly Plant.

DOE Should Develop AI-Based Foundation Models Fused with Traditional Computational Methods to Bring Paradigm Shift to Scientific Discovery

News Release

Foundation models are AI systems trained on vast amounts of data — often trillions of individual data points — and they are capable of learning new ways of modeling information and performing a range of tasks. A new National Academies report examines how the U.S. Department of Energy could use these models to potentially transform scientific discovery and innovation.

Dec 16, 2025
A 3D rendering background of various geometric shapes in blue and white, accented with orange spheres

Why Chemistry Might Be Our Best Clue to Life on Other Planets

Program News

The Chemistry in 2050–Space webinar brought together leading scientists to discuss how chemistry is essential for understanding the universe, from the origins of life on other planets to the adaptation of biology in extreme space environments. Panelists highlighted the need for more laboratory-based astrochemistry, addressed challenges in detecting biosignatures like phosphine, and emphasized the importance of innovative research and flexible mission approaches to advance space bioscience.

Jun 25, 2025
Hemispheric View of Venus Centered at 270° East Longitude. The view of Venus, after more than a decade of radar investigations culminating in the 1990-1994 NASA's Magellan mission, is centered at 270 degrees east longitude.

Our Expertise

The Physical Sciences, Systems, and Infrastructure program area brings together leading experts from academia, government, and industry to provide independent and forward-thinking advice to support technology development and identify critical future research directions across the mathematical and physical sciences and engineering. Our work shapes policy and guides decision making on topics such as the future of U.S. energy systems, infrastructure needs, smart manufacturing, military force modernization, mission-focused Service systems integration, and defense applications for emerging technologies. 

Our landmark studies explore the opportunities and challenges at the frontiers of technology innovation — from digital twins to advanced nuclear reactors — and provide actionable advice on ways to harness these new advances for the benefit of the nation. Our workshops and roundtables offer unparalleled forums to discuss complex and timely issues as they arise with experts from across disciplines and perspectives. 

Description

Addresses innovations in physical sciences – math, physics, chemistry – with a systems approach across disciplines and domains including: Energy/Electricity, Manufacturing/Materials, and S&T for Defense/Intelligence.

Work with Us
Looking for independent, nonpartisan guidance from the nation’s top subject-matter experts? We stand ready to help potential sponsors across a variety of sectors shape research and policy agendas, regulation, investments, operations, state and local initiatives, and more.
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