Physical Sciences, Systems, and Infrastructure Program Area

This program area sets research priorities, highlights critical future directions, and develops policy innovations to advance mathematical and physical sciences, energy systems, engineering and manufacturing, infrastructure and facilities, and defense and intelligence.

Work with us

In progress

Bundle of network cables during data transmission. 3d illustration.

News and Updates

DOE Should Develop AI-Based Foundation Models Fused with Traditional Computational Methods to Bring Paradigm Shift to Scientific Discovery

News Release

Foundation models are AI systems trained on vast amounts of data — often trillions of individual data points — and they are capable of learning new ways of modeling information and performing a range of tasks. A new National Academies report examines how the U.S. Department of Energy could use these models to potentially transform scientific discovery and innovation.

Dec 16, 2025

A 3D rendering background of various geometric shapes in blue and white, accented with orange spheres

Why Chemistry Might Be Our Best Clue to Life on Other Planets

Program News

The Chemistry in 2050–Space webinar brought together leading scientists to discuss how chemistry is essential for understanding the universe, from the origins of life on other planets to the adaptation of biology in extreme space environments. Panelists highlighted the need for more laboratory-based astrochemistry, addressed challenges in detecting biosignatures like phosphine, and emphasized the importance of innovative research and flexible mission approaches to advance space bioscience.

Jun 25, 2025

Hemispheric View of Venus Centered at 270° East Longitude. The view of Venus, after more than a decade of radar investigations culminating in the 1990-1994 NASA's Magellan mission, is centered at 270 degrees east longitude.

Exploring the New Nuclear Energy Landscape

Feature Story

The energy industry in the U.S. is undergoing rapid change, and the needs of “hyperscalers” and others have led to a resurgence of interest in nuclear energy. A recent workshop brought together experts in tech, policymaking, finance, and community engagement to discuss what comes next.

Feb 14, 2025