The Promise of Adolescence: Realizing Opportunity for All Youth, a new report from the National Academies of Sciences, Engineering, and Medicine, finds ample evidence that changes in brain structure and connectivity that happen in adolescence present young people with unique opportunities for positive, life-shaping development, and for recovery from past adversity. The report provides multiple recommendations for policy and practice that capitalize on these developmental opportunities and address inequities–such as in health care and education–that undermine the well-being of many adolescents and leave them less able to take advantage of the promise offered by this stage of life.