As the opioid epidemic continues to cause suffering for millions of Americans, the United States government is responding in many different ways. In 2016, lawmakers passed the Comprehensive Addiction and Recovery Act, which included several grant programs to help reduce opioid-related harm and promote recovery from substance use disorder. As part of this law, the National Academies of Sciences, Engineering, and Medicine was asked to issue a series of studies evaluating the success of these grant programs, which are funded and administered by the Substance Abuse and Mental Health Services Administration.