Acceptable Macronutrient Distribution Ranges (AMDRs) for carbohydrate, fat, and protein were developed and incorporated into the Dietary Reference Intakes (DRI) framework to address the growing body of evidence on macronutrient intakes and the risk of chronic diseases. Since their introduction, challenges related to applying the AMDRs have been noted. Additionally, a change to the DRI framework, allowing chronic disease risk reduction considerations to be addressed in a structured and consistent way using a new DRI value, the Chronic Disease Risk Reduction (CDRR), has resulted in the question of whether the AMDR should be retained or removed from the DRI process.