In 2011, an expert committee under the Science and Technology for Sustainability (STS) Program released a report for the U.S. Environmental Protection Agency (EPA) presenting a framework for incorporating sustainability into EPA’s principles and decision making. The framework is intended to help the agency better assess the social, environmental, and economic impacts of various options as it makes decisions. This report builds on existing sustainability efforts that EPA’s Office of Research and Development has conducted by strengthening the analytic and scientific basis for sustainability as it applies to human health and environmental protection within the Agency’s decision-making process.