New and improved therapies to treat and protect against drug dependence and
abuse are urgently needed. In the United States alone about 50 million people regularly
smoke tobacco and another 5 million are addicted to other drugs. In a given
year, millions of these individuals attempt—with or without medical assistance—to
quit using drugs, though relapse remains the norm. Furthermore, each year several
million teenagers start smoking and nearly as many take illicit drugs for the first
time. Research is advancing on promising new means of treating drug addiction
using immunotherapies and sustained-release (depot) medications. The aim of this
research is to develop medications that can block or significantly attenuate the psychoactive
effects of such drugs as cocaine, nicotine, heroin, phencyclidine, and
methamphetamine for weeks or months at a time. This represents a fundamentally
new therapeutic approach that shows promise for treating drug addiction problems
that were difficult to treat in the past. Despite their potential benefits, however, several
characteristics of these new methods pose distinct behavioral, ethical, legal, and
social challenges that require careful scrutiny. Such issues can be considered unique
aspects of safety and efficacy that are fundamentally related to the distinct nature
and properties of these new types of medications.
Institute of Medicine and National Research Council. 2004. New Treatments for Addiction: Behavioral, Ethical, Legal, and Social Questions. Washington, DC: The National Academies Press.
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