Issues in Risk Assessment (1993)
Chapter: Appendix B Workshop Program
Appendix B
Workshop Program
Thursday, November 8, 1990 | |
8:30 | Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman |
8:35 | Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman |
8:45 | Biological Factors in Two-Stage Models |
| Presenter: Alfred Knudson, Fox Chase Cancer Center |
9:30 | Discussant: Robert Maronpot, NIEHS |
9:50 | Questions and Comments |
10:10 | Break |
10:30 | Two-Stage Clonal Expansion Model of Carcinogenesis |
| Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center |
11:15 | Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc. |
12:00 | Questions and Comments |
12:15 | Lunch |
1:15 | Application of the Two-Stage Model to Animal Data |
| Presenter: Samuel Cohen, University of Nebraska Medical Center |
2:00 | Discussants: William Farland, EPA; Carl Barrett, NIEHS |
2:30 | Questions and Comments |
2:45 | General Discussion |
| Leader: Richard Griesemer, NIEHS |
| Issues: |
| • The scientific basis for two-stage models of carcinogenesis. • Can two-stage models of carcinogenesis adequately represent biological processes that may involve a variety of mechanisms? • The implications for the design of rodent bioassays. • The implications for health risk assessment. |
3:30 | Adjourn |
