Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values
2016

Consensus

You must be logged in to download this publication.

Select Book Type

Paperback - $71.10
Ebook - $58.49

See project
Request an exam or desk copy

Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration.

Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

Additional materials

Press Release
Download the slides from the release briefing
Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

Publication information

230 pages · 7 x 10 · paperback
ISBN Paperback: 0-309-43787-3
ISBN Ebook: 0-309-43788-1
DOI: https://doi.org/10.17226/23405

Suggested citation

National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press.

Import this citation to:

Bibtext
EndNote
Reference manager

First Name
Last Name
Email (required)
I agree to receive emails from the National Academies (required)

We respect your privacy and will never share your information.

Search this publication

Front Matter i-xii
Summary 1-11
1 Introduction 12-25
2 The State of Knowledge of the Molecular Biology, Population Genetics, and Ecology of Gene-Drive Modified Organisms 26-48
3 Case Studies to Examine Questions About Gene-Drive Modified Organisms 49-62
4 Charting Human Values 63-85
5 Phased Testing and Scientific Approaches to Reducing Potential Harms of Gene Drives 86-111
6 Assessing Risks of Gene-Drive Modified Organisms 112-130
7 Engaging Communities, Stakeholders, and Publics 131-146
8 Governing Gene Drive Research and Applications 147-176
9 Gene Drives on the Horizon: Overarching Considerations 177-179
Glossary 180-186
Acronyms 187-187
Appendix A Agenda for the Workshop on the Science, Ethics, and Governance Considerations for Gene Drive Research 188-189
Appendix B List of Gene Drive Webinars 190-191
Appendix C Mosquito Control Strategies 192-196
Appendix D Rodent Control Strategies 197-200
Appendix E A Brief History of Ecological Risk Assessment 201-209
Appendix F Biographical Sketches of Committee Members 210-218

Log In

Former MyNAP users: You'll need to reset your password on your first login to MyAcademies. Click "Forgot password" below to receive a reset link via email. Having trouble? Visit our FAQ page to contact support.

Members of the National Academy of Sciences, National Academy of Engineering, or National Academy of Medicine should log in through their respective Academy portals.

Email (required)
Password (required)

Don't have an account?

Register

Email (required)
New password (required)
Retype password (required) Password must be at least 8 characters
I accept the terms of use
terms of use

Thank You

Thank you for creating a MyAcademies account!

Enjoy free access to thousands of National Academies' publications, a 10% discount off every purchase, and build your personal library.

Forgot Password

Enter the email address for your MyAcademies (formerly MyNAP) account to receive password reset instructions.

Email (required)

Reset Requested

We sent password reset instructions to your email . Follow the link in that email to create a new password. Didn't receive it? Check your spam folder or contact us for assistance.

Reset Password

New password (required)
Retype password (required) Password must be at least 8 characters

Reset Password

Your password has been reset.

Verify email

Verify Your Email Address

We sent a verification link to your email. Please check your inbox (and spam folder) and follow the link to verify your email address. If you did not receive the email, you can request a new verification link below

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016)

Chapter: Glossary

Additional materials

Publication information

Suggested citation

My Academies

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016)

Chapter: Glossary