Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values
2016

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Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries. However, due to their intrinsic qualities of rapid spread and irreversibility, gene drive systems raise many questions with respect to their safety relative to public and environmental health. Because gene drive systems are designed to alter the environments we share in ways that will be hard to anticipate and impossible to completely roll back, questions about the ethics surrounding use of this research are complex and will require very careful exploration.

Gene Drives on the Horizon outlines the state of knowledge relative to the science, ethics, public engagement, and risk assessment as they pertain to research directions of gene drive systems and governance of the research process. This report offers principles for responsible practices of gene drive research and related applications for use by investigators, their institutions, the research funders, and regulators.

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Framework for Addressing Ethical Dimensions of Emerging and Innovative Biomedical Technologies: A Synthesis of Relevant National Academies Reports

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230 pages · 7 x 10 · paperback
ISBN Paperback: 0-309-43787-3
ISBN Ebook: 0-309-43788-1
DOI: https://doi.org/10.17226/23405

Suggested citation

National Academies of Sciences, Engineering, and Medicine. 2016. Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values. Washington, DC: The National Academies Press.

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Front Matter i-xii
Summary 1-11
1 Introduction 12-25
2 The State of Knowledge of the Molecular Biology, Population Genetics, and Ecology of Gene-Drive Modified Organisms 26-48
3 Case Studies to Examine Questions About Gene-Drive Modified Organisms 49-62
4 Charting Human Values 63-85
5 Phased Testing and Scientific Approaches to Reducing Potential Harms of Gene Drives 86-111
6 Assessing Risks of Gene-Drive Modified Organisms 112-130
7 Engaging Communities, Stakeholders, and Publics 131-146
8 Governing Gene Drive Research and Applications 147-176
9 Gene Drives on the Horizon: Overarching Considerations 177-179
Glossary 180-186
Acronyms 187-187
Appendix A Agenda for the Workshop on the Science, Ethics, and Governance Considerations for Gene Drive Research 188-189
Appendix B List of Gene Drive Webinars 190-191
Appendix C Mosquito Control Strategies 192-196
Appendix D Rodent Control Strategies 197-200
Appendix E A Brief History of Ecological Risk Assessment 201-209
Appendix F Biographical Sketches of Committee Members 210-218

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Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016)

Chapter: 5 Phased Testing and Scientific Approaches to Reducing Potential Harms of Gene Drives

Additional materials

Publication information

Suggested citation

My Academies

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (2016)

Chapter: 5 Phased Testing and Scientific Approaches to Reducing Potential Harms of Gene Drives