Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use (2020)

Chapter: Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation

Previous Chapter: Appendix B: Literature Review
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 257.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 258.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 259.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 260.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 261.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 262.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 263.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 264.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 265.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 266.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 267.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 268.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 269.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 270.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 271.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 272.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 273.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 274.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 275.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 276.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 277.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 278.

Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 257
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 258
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 259
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 260
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 261
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 262
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 263
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 264
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 265
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 266
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 267
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 268
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 269
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 270
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 271
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 272
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 273
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 274
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 275
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 276
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 277
Suggested Citation: "Appendix C: Commissioned Paper: Topical Dosage Form Development and Evaluation." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 278
Next Chapter: Appendix D: Glossary
Subscribe to Email from the National Academies
Keep up with all of the activities, publications, and events by subscribing to free updates by email.