Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use (2020)

Chapter: 4 Gaps in Regulation, Oversight, and Surveillance

Previous Chapter: 3 Fundamentals, Use, and Common Ingredients in Compounded Topical Pain Creams
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 63.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 64.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 65.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 66.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 67.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 68.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 69.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 70.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 71.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 72.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 73.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 74.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 75.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 76.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 77.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 78.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 79.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 80.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 81.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 82.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 83.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 84.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 85.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.

There was a problem loading page 86.

Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 63
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 64
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 65
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 66
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 67
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 68
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 69
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 70
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 71
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 72
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 73
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 74
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 75
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 76
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 77
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 78
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 79
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 80
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 81
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 82
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 83
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 84
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 85
Suggested Citation: "4 Gaps in Regulation, Oversight, and Surveillance." National Academies of Sciences, Engineering, and Medicine. 2020. Compounded Topical Pain Creams: Review of Select Ingredients for Safety, Effectiveness, and Use. Washington, DC: The National Academies Press. doi: 10.17226/25689.
Page 86
Next Chapter: 5 Science of Compounded Topical Pain Creams
Subscribe to Email from the National Academies
Keep up with all of the activities, publications, and events by subscribing to free updates by email.