| AoA | Analysis of Alternatives |
| B&R | budget and reporting |
| CEPE | Cost Estimating and Program Evaluation |
| CRENEL | Commission to Review the Effectiveness of the National Energy Laboratories |
| DoD | Department of Defense |
| DOE | Department of Energy |
| DOE-EM | DOE Office of Environmental Management |
| FEVS | Federal Employee Viewpoint Survey |
| FFRDC | federally funded research and development center |
| GAO | Government Accountability Office |
| KCNSC | Kansas City National Security Campus |
| LANL | Los Alamos National Laboratory |
| LDRD | laboratory directed research and development |
| LLNL | Lawrence Livermore National Laboratory |
| M&O | management and operating |
| MOX | Mixed-Oxide Program |
| NA-APM | NNSA Office of Acquisition and Program Management |
| NAPA | National Academy of Public Administration |
| NNSA | National Nuclear Security Administration |
| NPR | Nuclear Posture Review |
| NWC | Nuclear Weapons Council |
| OMB | Office of Management and Budget |
| PAS | presidentially appointed and subject to Senate confirmation |
| PPBE | planning, programming, budgeting, and evaluation |
| R&D | research and development |
| S&E | science and engineering |
| SES | Senior Executive Service |
| SNL | Sandia National Laboratories |
| SRS | Savannah River Site |