Appendix C

Committee Member and Staff Biographies

COMMITTEE MEMBER BIOGRAPHIES

Bruce N. Calonge, M.D., M.P.H. (chair), is the associate dean for public health practice and a professor of epidemiology at the Colorado School of Public Health and an associate professor of family medicine at the Colorado School of Medicine, Aurora, Colorado. He was previously president and CEO of the Colorado Trust, a private grant-making foundation dedicated to achieving health equity for all Coloradans. Dr. Calonge chairs the National Academies Board on Population Health and Public Health Practice (BPH) and is a member of the Roundtable on the Advancement of Health Equity. Dr. Calonge has substantial expertise and experience in evidence assessment, synthesis, and causal decision making, having developed and updated methods in past roles as chair of the Centers for Disease Control and Prevention (CDC) Community Preventive Services Task Force, U.S Preventive Services Task Force, and CDC Evaluating Genomic Applications for Practice and Prevention Working Group; and founding member of the Health Resources and Services Administration’s Advisory Committee on Heritable Disorders in Newborns and Children, for which he is now the chair. Dr. Calonge also served as the chief medical officer of the Colorado Department of Public Health and Environment. Dr. Calonge has served on five National Academies consensus committees and chaired three of them; four of these required developing novel evidence synthesis and causal-related recommendation frameworks. He is an elected member of the National Academy of Medicine. He received his M.D. from the University of Colorado and his M.P.H. from the University of Washington, where he also completed his

preventive medicine residency. He completed his family medicine residency at Oregon Health Sciences University.

Lawrence Deyton, M.D., M.S.P.H., is the Murdock Head Professor of Medicine and Health Policy and senior associate dean for clinical public health at the George Washington University School of Medicine and Health Sciences. He served at several federal agencies, including as the founding director of the Food and Drug Administration (FDA) Center for Tobacco Products, where he created scientific, research, regulatory, and enforcement frameworks for FDA tobacco product regulation. Before FDA, Dr. Deyton held several national leadership positions at the Department of Veterans Affairs (VA) for 10 years (1999–2009) and was the chief public health and environmental hazards officer (2005–2009), where he oversaw VA’s public health programs, including environmental hazards, women’s health, occupational health, and emergency preparedness and response for VA’s health system. While in this position, Dr. Deyton presented to the National Academies Committee on Improving the Presumptive Disability Decision-Making Process for Veterans and wrote a white paper about the process of how Institute of Medicine (IOM) reports on exposures and health outcomes of Vietnam and Gulf War veterans were reviewed internally by VA to be used in the presumption determination process, but he was not involved in revising the presumption decision process itself and left VA soon after the report was received. Dr. Deyton has been a volunteer physician for the Washington DC VA medical center for 23 years and continues to see and treat patients, specializing in HIV and AIDS. He has not performed compensation and pension examinations. Since leaving VA, he has not consulted for or had research collaborations with VA. Dr. Deyton also served for 11 years in leadership positions at the National Institute of Allergy and Infectious Diseases, for 6 years in the Office of the Assistant Secretary for Health at the Department of Health and Human Services, and as a legislative aide with the House of Representatives Subcommittee on Health and the Environment in the 1970s. Dr. Deyton was a founder of the Whitman-Walker Clinic, now a community-based AIDS service organization in Washington, DC, in 1978. In 2011, Dr. Deyton was a finalist for the prestigious Samuel J. Heyman Service to America Medal for his outstanding contributions to the health, safety, and well-being of Americans, and in 2019, he received the James Bruce Award for Distinguished Contributions in Preventive Medicine by the American College of Physicians. He earned his M.D. from George Washington University and his M.S.P.H. at Harvard School of Public Health.

Javier I. Escobar, M.D., M.Sc., is professor emeritus of psychiatry and family medicine at Rutgers University. He has been an active researcher in clinical

psychopharmacology, psychiatric epidemiology, psychiatric diagnosis, cross-cultural medicine, mental disorders in primary care, somatic symptom disorders, and global mental health. He has been the principal investigator of National Institutes of Health (NIH)–funded grants (medically unexplained symptoms, mental health in primary care, and global mental health). He has published more than 250 scientific articles in books and journals and served on several advisory committees and task forces for NIH, World Health Organization (WHO), FDA, VA, Robert Wood Johnson Foundation, and American Psychiatric Association (DSM-5 Task Force). Dr. Escobar was on two National Academies committees focusing on veterans’ health issues (Gulf War and Health volume 10 and Treatment of Chronic Multisymptom Illness). His career included positions of full professor of psychiatry at University of California, Los Angeles (UCLA), University of Connecticut, and Florida International University. He was also the chair of psychiatry and associate dean for global health at Rutgers University Biomedical Health Sciences. He received his M.D. from Universidad de Antioquia, Medellin, Colombia, completed his specialty training in psychiatry, and obtained an M.Sc. in psychiatry/medical genetics at the University of Minnesota.

James Giordano, Ph.D, is Pellegrino Center Professor of Neurology, Biochemistry, and Ethics at Georgetown University Medical Center; and chief of the Neuroethics Studies Program; director of the Program in Biotechnology, Biosecurity and Ethics of the Cyber-SMART Center; and chair of the Subprogram in Military Medical Ethics at Georgetown University. In these roles, he provides education and training, consultation, and oversight for ethical issues focused on clinical medicine and biomedical research. He is bioethicist-in-residence at the Defense Medical Ethics Center; senior fellow in biosecurity, technology, and ethics at the U.S. Naval War College, Newport, RI; and distinguished fellow in science, technology, and ethics of the Stockdale Center of the U.S. Naval Academy. Dr. Giordano is an elected member of the European Academy of Science and Arts and a Fellow of the Royal Society of Medicine (U.K.). A former Naval officer, holding designations as an aerospace physiologist, research physiologist, and research psychologist, he served with the Navy and Marine Corps, with the rank of lieutenant. He maintains no affiliation with VA for medical or other benefits. Dr. Giordano received his Ph.D. (with highest honors) in biopsychology from the City University of New York, received postgraduate training in ethics and health policy at Loyola University (IL), and completed a postdoctoral fellowship in neuropathology and toxicology at the Johns Hopkins University School of Public Health.

Francine Laden, Sc.D., is professor of environmental epidemiology and associate chair of the Department of Environmental Health at the Harvard

T.H. Chan School of Public Health and an associate professor of medicine at the Harvard Medical School and the Brigham & Women’s Hospital. Her research interests focus on the environmental epidemiology of chronic diseases, including cancer, respiratory, and cardiovascular disease, and exposures of air pollution (from ambient and occupational sources), persistent organic pollutants, secondhand smoke, and the contextual environment (e.g., built environment and green spaces). She studies the geographic distribution of disease risk and all-cause and cardiovascular mortality among large cohorts. Dr. Laden has served on five National Academies committees, including three of the Gulf War and Health series (volumes 4, 8, and 10) and Contaminated Drinking Water at Camp Lejeune. She was a member of the Environmental Protection Agency (EPA) Science Advisory Board and past president of the International Society of Environmental Epidemiology. Dr. Laden received her Sc.D. in epidemiology and M.S. in environmental health from the Harvard T.H. Chan School of Public Health.

Juleen Lam, Ph.D., is an assistant professor at California State University East Bay in the Department of Public Health. Her research focuses on environmental epidemiology, evaluation of population exposures to environmental contaminants, risk assessment, and reproductive and developmental health. Over the past decade, Dr. Lam has been closely involved in developing systematic review methods for environmental health data and played a pivotal role in implementing, publishing, and disseminating these approaches in academic and government settings. Dr. Lam contributed to developing and implementing the University of California, San Francisco systematic review methodology (Navigation Guide) and has been involved with the GRADE (grading of recommendations assessment, development and evaluation) working group. Dr. Lam has published four case studies illustrating the implementation of systematic review methodology in environmental health and numerous other publications focused on specific aspects of systematic review (such as evaluating risk of bias, developing systematic evidence maps, and incorporating semiautomated machine learning software). Dr. Lam has served on four National Academies committees. She received her M.S. in environmental engineering management from George Washington University and her M.H.S. in biostatistics and Ph.D. in environmental health policy from the Johns Hopkins University Bloomberg School of Public Health.

Roger Lewis, M.D., Ph.D., is a senior physician in the Los Angeles County Department of Health Services, professor of emergency medicine at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA), and a statistical editor for JAMA. He is the senior medical scientist at Berry Consultants, LLC, a group that specializes in innovative

clinical trial design. Dr. Lewis’s expertise is on adaptive and Bayesian clinical trials, including platform trials; translational, clinical, health services, and outcomes research methodology; data and safety monitoring boards; and the oversight of clinical trials. He has broad expertise in interpreting experimental and observational clinical data. Dr. Lewis has served as a member of several advisory committees, including FDA’s Blood Products Advisory Committee, the Center for Biologics Evaluation and Research, and the Centers for Medicare & Medicaid Services Medicare Evidence Development & Coverage Advisory Committee. He has chaired data and safety monitoring boards for numerous federally funded, industry-sponsored, and multinational clinical trials. He has also served on multiple National Academies consensus committees. Dr. Lewis is a past president of the Society for Academic Emergency Medicine and was on the board of directors for the Society for Clinical Trials. He is also the former chair of the Department of Emergency Medicine at Harbor–UCLA Medical Center. He is a fellow of the American College of Emergency Physicians, the American Statistical Association, and the Society for Clinical Trials. Dr. Lewis is an elected member of the National Academy of Medicine. He received both his Ph.D. in biophysics and his M.D. from Stanford University.

Jennifer S. Lin, M.D., M.C.R., F.A.C.P., is a board-certified practicing general internist in primary care with Northwest Permanente and the director of the Kaiser Permanente Evidence-Based Practice Center. Dr. Lin’s career interests have focused on evidence-based medicine and health care policy in primary and preventive care. She serves as the principal investigator on several contracts to support the U.S. Preventive Services Task Force, including work conducting systematic review, methods development, and portfolio management. She is recognized as an expert in systematic review methodology, evidence-based medicine, and clinical prevention. Dr. Lin has significant experience conducting reviews across a wide range of areas, including complex interventions, care of older adults, screening and evaluation of medical testing, prognosis, and risk prediction. Dr. Lin also serves on the American College of Physicians Clinical Guideline Committee and has done consultant methods work for international and national guideline committees, federal and nongovernmental agencies, and systematic review groups. Dr. Lin received her medical degree from New York University School of Medicine.

Lorenz Rhomberg, Ph.D., is an advising principal at the consulting firm Gradient. He is an expert in quantitative human health risk assessment, including dose–response analysis, pharmacokinetic modeling, probabilistic methods, and extrapolation of toxic effects from animals to humans. He has published several high-profile risk assessments of industrial chemicals, with

particular expertise in chlorinated solvents and endocrine-active agents, that have been used to revise national-level environmental exposure standards for these agents. His experience encompasses work relating to a variety of regulatory programs, including the Comprehensive Environmental Response; Compensation and Liability Act; Federal Insecticide, Fungicide, and Rodenticide Act; and Toxic Substances Control Act (TSCA). Before Gradient, Dr. Rhomberg was on the faculty of the Harvard T.H. Chan School of Public Health; earlier, he spent 10 years as a risk assessor at EPA. Dr. Rhomberg is a fellow of the Academy of Toxicological Sciences, was recognized by the Society for Risk Analysis in 2009 as Outstanding Practitioner of the Year, and earned the 2017 Arnold V. Lehman award. He has been a member of four previous National Academies consensus committees. Dr. Rhomberg received his Ph.D. in population biology from the State University of New York at Stony Brook.

Daniele Wikoff, Ph.D., is the health sciences practice director at ToxStrategies, LLC. She specializes in the use of evidence-based methods to support hazard and risk assessment applications for a wide variety of consumer products, food ingredients and additives, pharmaceuticals, and industrial chemicals. She has applied these methods across evidence streams (human, experimental animal, mechanistic) and to heterogeneous data sets to examine a variety of outcomes. Dr. Wikoff is well versed in frameworks and guidance from authorities worldwide, including National Toxicology Program—Office of Health Assessment and Translation, EPA-TSCA and EPA-Integrated Risk Information System (IRIS), European Food Safety Authority/European Chemicals Agency, IOM, WHO, GRADE, and Cochrane, that are used to manage and facilitate the systematic review process. Dr. Wikoff uses both qualitative and quantitative integration techniques to characterize confidence and/or uncertainty in hazard analyses, points of departure, estimates of relative potency, and dose–response relationships. She has particular interest in methods development related to defining and evaluating data quality and how elements of internal, construct, and external validity can be used to transparently inform conclusions and provide critical information to decision makers. Dr. Wikoff is vice chair of the Science Advisory Council for the Evidence-Based Toxicology Collaboration, cochair of its Education Workgroup, and an associate editor for Toxicological Sciences and Regulatory Toxicology and Pharmacology. She was a member of the National Academies Committee to Evaluate the IRIS Protocol for Inorganic Arsenic. She received her Ph.D. in toxicology from the University of North Carolina at Chapel Hill.

STAFF BIOGRAPHIES

Anne N. Styka, M.P.H., PMP, is a senior program officer in the Health and Medicine Division (HMD) of the National Academies. She has worked on more than 14 consensus studies (directing or codirecting 7 of them) on a broad range of topics related to the health of military and veteran populations and environmental and occupational health. Such studies include mental health treatment offered in the Department of Defense (DoD) and VA; designing and evaluating epidemiologic research studies of deployment-related exposures, including burn pits, dioxin, and other chemical agents and the use of antimalarial drugs; and a research program fostering new research studies using data and biospecimens collected as part of the 20-year Air Force Health Study. Before the National Academies, Ms. Styka spent several years as an epidemiologist for the New Mexico Department of Health and the Albuquerque Area Southwest Tribal Epidemiology Center, specializing in survey design and the analysis of behavioral risk factors and injury. She also spent several months in Zambia as the epidemiologist on a study of silicosis and other nonmalignant respiratory diseases among copper miners. She has several peer-reviewed publications and has contributed to numerous state and national reports. She received her B.S. in cell and tissue bioengineering from the University of Illinois at Chicago, has an M.P.H. in epidemiology from the University of Michigan, and is a certified project management professional.

Roberta Wedge, M.S., is a senior program officer in HMD of the National Academies. She has directed or substantially contributed to numerous studies on veterans’ and service members’ health, including four reports on health outcomes seen in veterans serving in the 1990–1991 Gulf War; smoking cessation in military and veteran populations; the long-term health consequences of exposure to burn pits in Iraq and Afghanistan; and a comprehensive assessment of the treatment efforts for posttraumatic stress disorder in DoD and VA. She has also directed studies on the peer-review process for the DoD Congressionally Directed Medical Research Programs and a study examining the Department of Labor’s Site Exposure Matrix. She directed a study for FDA on evidence-based clinical practice guidelines for prescribing opioids for acute pain and one for the Social Security Administration on diagnosing and treating adult cancers. Earlier, she directed environmental exposure studies in the Division on Earth and Life Studies Board on Environmental Studies and Toxicology at the National Academies. Before the National Academies, Ms. Wedge was a consultant on environmental and human health for EPA and FDA. She also served as the director of emergency response for the Food Safety and Inspection Service

at the U.S. Department of Agriculture. She received her M.S. in botany (plant physiology) from The Pennsylvania State University.

Alexandra McKay, M.A., is a research associate in HMD. She graduated from Yale University, where she received her M.A. in archaeological studies. She also worked for the National Park Service as an interpretation ranger, concentrating on science education and public engagement. While at the National Academies, she has contributed to consensus studies concerning environmental health, including Guidance on PFAS Testing and Health Outcomes and Reassessment of the VA’s Airborne Hazards and Open Burn Pit Registry. She has also supported other convening activities, including Children’s Environmental Health: A Workshop on Future Priorities for Environmental Health Sciences.

Rose Marie Martinez, Sc.D., has been the senior board director of the National Academies’ HMD BPH since 1999. BPH addresses the science base for population health and public health interventions and examines the capacity of the health system, particularly the public health infrastructure, to support disease prevention and health promotion activities. BPH has examined such topics as the safety of vaccines and other drugs; systems for evaluating and ensuring drug safety post-marketing; the health effects of cannabis and cannabinoids; the health effects of environmental exposures; population health improvement strategies; integration of medical care and public health; women’s health services; health disparities; health literacy; tobacco control strategies; and chronic disease prevention. Dr. Martinez was awarded the 2010 IOM Research Cecil Award for significant contributions to IOM reports of exceptional quality and influence. Before the National Academies, she was a senior health researcher at Mathematica Policy Research (1995–1999), where she researched the impact of health system change on public health infrastructure, access to care for vulnerable populations, managed care, and the health care workforce. She is a former assistant director for health financing and policy with the General Accounting Office, where she directed evaluations and policy analysis in the area of national and public health issues (1988–1995). Her experience also includes 6 years directing research studies for the Regional Health Ministry of Madrid, Spain (1982–1988). She is a member of the Council on Education for Public Health, the accreditation body for schools of public health and public health programs. She received an Sc.D. from the Johns Hopkins School of Hygiene and Public Health.