Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop (2024)
Chapter: Appendix C: Workshop Agenda
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Appendix B: Workshop Statement of Task
C
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
C
Workshop Agenda
Day 1: Mechanisms Underlying Infection-Associated Chronic Illnesses
| 8:30–8:45 a.m. | Welcome remarks, workshop overview, and goals |
| Welcome | |
| Peter Daszak, EcoHealth Alliance | |
| Chair, Forum on Microbial Threats | |
| John Krystal, Yale University | |
| Cochair, Forum on Neuroscience and Nervous System Disorders | |
| Introduction and workshop overview | |
| Tim Coetzee, National Multiple Sclerosis Society | |
| Workshop Cochair | |
| Sponsor perspectives | |
| Lyle Petersen, U.S. Centers for Disease Control and Prevention | |
| Ben Nemser, Steven & Alexandra Cohen Foundation |
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
| 8:45–10:00 a.m. | Session 1: Introduction to infection-associated chronic illnesses |
| Moderator: Rafael Obregon, UNICEF | |
| Keynote | |
| Tim Henrich, University of California, San Francisco | |
| Introduction and a historical perspective | |
| Anthony Komaroff, Harvard Medical School; Brigham and Women’s Hospital | |
| Stakeholder perspectives | |
| Joseph Breen, National Institutes of Health (NIH) RECOVER | |
| Harlan Krumholz, Yale School of Medicine | |
| Hannah Davis, Patient-Led Research Collaborative | |
| Meghan O’Rourke, Yale University | |
| Author of The Invisible Kingdom: Reimagining Chronic Illness | |
| Q&A | |
| 10:00–10:15 a.m. | BREAK |
| 10:15 a.m.–12:00 p.m. | Session 2: Common mechanistic factors of infection-associated chronic illnesses |
| Host-mediated factors (part 1) | |
| Moderator: Peter Rowe, Johns Hopkins University | |
| Immune Dysfunction | |
| Post-COVID syndrome and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): Evidence for a role of autoantibodies and endothelial dysfunction and development of targeted therapies | |
| Carmen Scheibenbogen, Charité University | |
| Viral reactivation | |
| Michael Peluso, University of California, San Francisco |
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
| Autonomic Dysfunction | |
| Overview of orthostatic intolerance: Risk factors and treatments | |
| Satish Raj, University of Calgary | |
| Common underlying mechanisms of chronic illness: Lessons from postural orthostatic tachycardia syndrome (POTS), ME/CFS, and long COVID | |
| Mitchell Miglis, Stanford University | |
| Q&A | |
| 12:00–1:00 p.m. | LUNCH |
| 1:00 pm–3:00 p.m. | Session 3: Common mechanistic factors of infection-associated chronic illnesses |
| Host mediated factors (part 2) | |
| Moderator: Brian Fallon, Columbia University | |
| Effect of inflammation on the brain: Significance for chronic illnesses | |
| Andrew Miller, Emory University | |
| Role of the microbiome in ME/CFS | |
| Julia Oh, The Jackson Laboratory | |
| Pathogen-mediated factors and pathogen persistence | |
| Viral persistence and development of chronic illness: Lessons from Epstein-Barr virus (EBV) | |
| Bill Robinson, Stanford University | |
| Pathogen distribution and persistence: Learnings from SARS-CoV-2 | |
| Dan Chertow, NIH | |
| Modeling pathogen persistence: Lessons from animal studies | |
| Monica Embers, Tulane University | |
| Q&A |
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
| 3:00–3:15 p.m. | BREAK |
| 3:15–4:45 p.m. | Session 4: Future opportunities and research priorities in diagnostics |
| Moderator: Avindra Nath, National Institute of Neurological Disorders and Stroke (NINDS), NIH | |
| Biomarkers for Lyme disease and posttreatment Lyme | |
| John Aucott, Johns Hopkins University | |
| Biomarkers for EBV and associations with multiple sclerosis (MS) | |
| Alberto Ascherio, Harvard T.H. Chan School of Public Health | |
| Microclots as a common indicator of chronic disease | |
| Resia Pretorius, Stellenbosch University | |
| Next-generation and metagenomic sequencing | |
| Charles Chiu, University of California, San Francisco | |
| Q&A | |
| 4:45–5:00 p.m. | Synthesis and adjourn |
| Amy Proal, PolyBio Research Foundation |
END OF DAY 1
Day 2: Clinical Advancements and Collaboration
| 8:30–9:00 a.m. | Welcome remarks, review of day 1 |
| Welcome and introduction | |
| Tim Endy, Coalition for Epidemic Preparedness Innovations (CEPI) | |
| Workshop Cochair | |
| Keynote | |
| Hilary Marston | |
| Chief Medical Officer, U.S. Food and Drug Administration |
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
| Q&A | |
| 9:00–10:15 a.m. | Session 5: Patient-driven research panel |
| Moderator: Liz Horn, Lyme Disease Biobank | |
| Panel: | |
| Lisa McCorkell, Patient-Led Research Collaborative | |
| Oved Amitay, Solve ME/CFS | |
| Lorraine Johnson, MyLymeData | |
| Liz Horn, Lyme Disease Biobank | |
| Q&A | |
| 10:15–10:30 a.m. | BREAK |
| 10:30 a.m.–12:00 p.m. | Session 6: Research innovation and required infrastructures |
| Moderator: Tim Endy, CEPI | |
| Diagnostic journeys of long COVID patients | |
| Linda Geng, Stanford University | |
| Ultrasensitive diagnostic assays: Examples with SARS-CoV-2 and long COVID | |
| David Walt, Harvard University | |
| Translating infection-associated chronic illnesses research into the clinic in drug repurposing | |
| Steven Deeks, University of California, San Francisco | |
| Treatment approaches to posttreatment Lyme disease and a new clinical trials network | |
| Brian Fallon, Columbia University | |
| Q&A | |
| 12:00–1:00 p.m. | LUNCH |
| 1:00–2:45 p.m. | Session 7: Future opportunities and research priorities in therapeutics |
| Moderator: Tim Coetzee, National Multiple Sclerosis Society |
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
| Development of oral antiviral for COVID-19 | |
| Ravi Shankar Singh, Pfizer | |
| Development of antivirals and combination therapies for infection-associated chronic illnesses | |
| Sara Cherry, University of Pennsylvania | |
| Clinical trials for multisystem inflammatory syndrome in children (MIS-C) and long COVID | |
| Alessio Fasano, Harvard University | |
| Long Lyme: Opportunities for prevention and treatment | |
| Kim Lewis, Northeastern University | |
| Clinical care for patients of various infection-associated chronic illnesses | |
| David Putrino, Mount Sinai Health System | |
| Q&A | |
| 2:45–3:50 p.m. | Session 8: Developing a shared research agenda: Challenges and opportunities |
| Moderators: | |
| Avindra Nath, NINDS, NIH | |
| Amy Proal, PolyBio Research Foundation | |
| Lorraine Johnson, MyLymeData | |
| Peter Rowe, Johns Hopkins University | |
| Q&A | |
| 3:50–4:00 p.m. | Synthesis and close |
| Tim Endy, CEPI | |
| Tim Coetzee, National Multiple Sclerosis Society | |
| Workshop Cochairs |
END OF WORKSHOP
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
Suggested Citation:
"Appendix C: Workshop Agenda." National Academies of Sciences, Engineering, and Medicine. 2024. Toward a Common Research Agenda in Infection-Associated Chronic Illnesses: Proceedings of a Workshop. Washington, DC: The National Academies Press.
doi: 10.17226/27462.
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