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References

Anderson, A. M., J. L. Lennox, M. M. Mulligan, D. W. Loring, H. Zetterberg, K. Blennow, C. Kessing, R. Koneru, K. Easley, and W. R. Tyor. 2017. Cerebrospinal fluid interferon alpha levels correlate with neurocognitive impairment in ambulatory HIV-infected individuals. Journal of Neurovirology 23(1):106-112.

Aucott, J. N., M. J. Soloski, A. W. Rebman, L. A. Crowder, L. J. Lahey, C. A. Wagner, W. H. Robinson, and K. T. Bechtold. 2016. CCL19 as a chemokine risk factor for posttreatment lyme disease syndrome: a prospective clinical cohort study. Clinical and Vaccine Immunology 23(9).

Bach, K. 2022a. Is ‘Long COVID’ worsening the labor shortage? Brookings Institute. https://www.brookings.edu/articles/is-long-covid-worsening-the-labor-shortage/ (accessed September 13, 2023).

Bach, K. 2022b. New data shows Long COVID is keeping as many as 4 million people out of work. Brookings Institute. https://www.brookings.edu/articles/new-data-shows-long-covid-is-keeping-as-many-as-4-million-people-out-of-work/ (accessed September 20, 2023).

Bains, J. S., K. A. Sharkey. 2022. Stress and immunity – the circuit makes the difference. Nature Immunology 23:1137-1139.

Balcom, E. F., A. Nath, and C. Power. 2021. Acute and chronic neurological disorders in COVID-19: Potential mechanisms of disease. Brain 144(12):3576-3588.

Bjornevik, K., K. L. Munger, M. Cortese, C. Barro, B. C. Healy, D. W. Niebuhr, A. I. Scher, J. Kuhle, and A. Ascherio. 2020. Serum neurofilament light chain levels in patients with presymptomatic multiple sclerosis. Journal of the American Medical Assoication Neurology 77(1):58-64.

Bjornevik, K., M. Cortese, B. C. Healy, J. Kuhle, M. J. Mina, Y. Leng, S. J. Elledge, D. W. Niebuhr, A. I. Scher, K. L. Munger, and A. Ascherio. 2022. Longitudinal analysis reveals high prevalence of Epstein-Barr virus associated with multiple sclerosis. Science 375(6578):296-301.

Bourne, K. M., R. S. Sheldon, J. Hall, M. Lloyd, K. Kogut, N. Sheikh, J. Jorge, J. Ng, D. V. Exner, J. V. Tyberg, and S. R. Raj. 2021. Compression garment reduces orthostatic tachycardia and symptoms in patients with postural orthostatic tachycardia syndrome. Journal of the American College of Cardiology 77(3):285-296.

Capuron, L., G. Pagnoni, D. F. Drake, B. J. Woolwine, J. R. Spivey, R. J. Crowe, J. R. Votaw, M. M. Goodman, and A. H. Miller. 2012. Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration. Archives of General Psychiatry 69(10):1044-1053. https://doi.org/10.1001/archgenpsychiatry.2011.2094.

CDC (Centers for Disease Control and Prevention). 2023a. Ebola disease: Survivors. https://www.cdc.gov/vhf/ebola/treatment/survivors.html (accessed September 21, 2023).

CDC. 2023b. Post-COVID conditions: Information for healthcare providers. https://www.cdc.gov/coronavirus/2019-ncov/hcp/clinical-care/post-covid-conditions.html (accessed October 4, 2023).

Ceban, F., S. Ling, L. M. W. Lui, Y. Lee, H. Gill, K. M. Teopiz, N. B. Rodrigues, M. Subramaniapillai, J. D. Di Vincenzo, B. Cao, K. Lin, R. B. Mansur, R. C. Ho, J. D. Rosenblat, K. W. Miskowiak, M. Vinberg, V. Maletic, and R. S. McIntyre. 2022. Fatigue and cognitive impairment in post-COVID-19 syndrome: A systematic review and meta-analysis. Brain, Behavior, and Immunity 101:93-135. https://doi.org/https://doi.org/10.1016/j.bbi.2021.12.020.

Cha, A. 2022. She went to one doctor, then another and another. The Washington Post. https://www.washingtonpost.com/health/2022/04/18/long-covid-medical-care-challenge/ (accessed October 5, 2023).

Chao, S., J. Lotfi, B. Lin, J. Shaw, S. Jhandi, M. Mahoney, B. Singh, L. Nguyen, H. Halawi, and L. N. Geng. 2022. Diagnostic journeys: Characterization of patients and diagnostic outcomes from an academic second opinion clinic. Diagnosis (Berl) 9(3):340-347. https://doi.org/10.1515/dx-2022-0029.

Coughlin, J. M., T. Yang, A. W. Rebman, K. T. Bechtold, Y. Du, W. B. Mathews, W. G. Lesniak, E. A. Mihm, S. M. Frey, E. S. Marshall, H. B. Rosenthal, T. A. Reekie, M. Kassiou, R. F. Dannals, M. J. Soloski, J. N. Aucott, and M. G. Pomper. 2018. Imaging glial activation in patients with post-treatment Lyme disease symptoms: A pilot study using [(11)C] DPA-713 PET. Journal of Neuroinflammation 15(1):346.

Cutler, D. M., and L. H. Summers. 2020. The COVID-19 pandemic and the $16 trillion virus. JAMA 324(15):1495-1496.

Davis, H. E., G. S. Assaf, L. McCorkell, H. Wei, R. J. Low, Y. Re’em, S. Redfield, J. P. Austin, and A. Akrami. 2021. Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. eClinicalMedicine 38:101019.

Davis, H. E., L. McCorkell, J. M. Vogel, and E. J. Topol. 2023. Long COVID: Major findings, mechanisms and recommendations. Nature Reviews Microbiology 21(3):133-146.

Doshi, S., J. G. Keilp, B. Strobino, M. McElhiney, J. Rabkin, and B. A. Fallon. 2018. Depressive symptoms and suicidal ideation among symptomatic patients with a history of Lyme disease vs two comparison groups. Psychosomatics 59(5):481-489.

Durstenfeld, M. S., M. J. Peluso, P. Kaveti, C. Hill, D. Li, E. Sander, S. Swaminathan, V. M. Arechiga, S. Lu, S. A. Goldberg, R. Hoh, A. Chenna, B. C. Yee, J. W. Winslow, C. J. Petropoulos, J. D. Kelly, D. V. Glidden, T. J. Henrich, J. N. Martin, Y. J. Lee, M. A. Aras, C. S. Long, D. J. Grandis, S. G. Deeks, and P. Y. Hsue. 2023. Reduced exercise capacity, chronotropic incompetence, and early systemic inflammation in cardiopulmonary phenotype long coronavirus disease 2019. Journal of Infectious Diseases 228(5):542-554.

Eisenberger, N. I., E. T. Berkman, T. K. Inagaki, L. T. Rameson, N. M. Mashal, and M. R. Irwin. 2010. Inflammation-induced anhedonia: Endotoxin reduces ventral striatum responses to reward. Biological Psychiatry 68(8):748-754. https://doi.org/https://doi.org/10.1016/j.biopsych.2010.06.010.

Fallon, B. A., J. G. Keilp, K. M. Corbera, E. Petkova, C. B. Britton, E. Dwyer, I. Slavov, J. Cheng, J. Dobkin, D. R. Nelson, and H. A. Sackeim. 2008. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for lyme encephalopathy. Neurology 70(13).

Fallon, B. A., T. Madsen, A. Erlangsen, and M. E. Benros. 2021. Lyme borreliosis and associations with mental disorders and suicidal behavior: A nationwide Danish cohort study. American Journal of Psychiatry 178(10):921-931.

FDA (Food and Drug Administration). 2018. Evaluating inclusion and exclusion criteria in clinical trials: Workshop report. https://www.federalregister.gov/documents/2018/08/23/2018-18232/evaluating-inclusion-and-exclusion-criteria-in-clinical-trials-workshop-report-availability (accessed October 17, 2023).

FDA. 2022. Patient-focused drug development: Selecting, developing, or modifying fit-for-purpose clinical outcome assessments. https://www.fda.gov/regulatory-information/search-fda-guidance-documents/patient-focused-drug-development-selecting-developing-or-modifying-fit-purpose-clinical-outcome (accessed September 12, 2023).

Felger, J. C., Z. Li, E. Haroon, B. J. Woolwine, M. Y. Jung, X. Hu, and A. H. Miller. 2016. Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression. Molecular Psychiatry 21(10):1358-1365.

Fitzgerald, B. L., B. Graham, M. J. Delorey, A. Pegalajar-Jurado, M. N. Islam, G. P. Wormser, J. N. Aucott, A. W. Rebman, M. J. Soloski, J. T. Belisle, and C. R. Molins. 2021. Metabolic response in patients with post-treatment Lyme disease symptoms/syndrome. Clinical Infectious Disease 73(7):e2342-e2349.

Ford, N. D., D. Slaughter, D. Edwards, A. Dalton, C. Perrine, A. Vahratian, and S. Saydah. 2023. Long COVID and significant activity limitation among adults, by age - United States, June 1-13, 2022, to June 7-19, 2023. MMWR Morbidity and Mortality Weekly Report 72(32):866-870. https://doi.org/10.15585/mmwr.mm7232a3.

Freitag, H., M. Szklarski, S. Lorenz, F. Sotzny, S. Bauer, A. Philippe, C. Kedor, P. Grabowski, T. Lange, G. Riemekasten, H. Heidecke, and C. Scheibenbogen. 2021. Autoantibodies to vasoregulative g-protein-coupled receptors correlate with symptom severity, autonomic dysfunction and disability in myalgic encephalomyelitis/chronic fatigue syndrome. Journal of Clinical Medicine 10(16).

Frieden, T. R. 2017. Evidence for health decision making—Beyond randomized, controlled trials. New England Journal of Medicine 377(5):465-475.

Furman, D., V. Jojic, S. Sharma, S. S. Shen-Orr, C. J. L. Angel, S. Onengut-Gumuscu, B. A. Kidd, H. T. Maecker, P. Concannon, C. L. Dekker, P. G. Thomas, and M. M. Davis. 2015. Cytomegalovirus infection enhances the immune response to influenza. Science Translational Medicine 7(281). https://doi.org/doi:10.1126/scitranslmed.aaa2293.

Gadila, S. K. G., G. Rosoklija, A. J. Dwork, B. A. Fallon, and M. E. Embers. 2021. Detecting Borrelia spirochetes: A case study with validation among autopsy specimens. Frontiers Neurology 12:628045.

GAO (Government Accountability Office). 2022. Science & tech spotlight: Long COVID. GAO-22-105666. https://www.gao.gov/products/gao-22-105666 (accessed October 17, 2023).

Garland, E. M., A. Gamboa, V. C. Nwazue, J. E. Celedonio, S. Y. Paranjape, B. K. Black, L. E. Okamoto, C. A. Shibao, I. Biaggioni, D. Robertson, A. Diedrich, W. D. Dupont, S. R. Raj. 2021. Effect of high dietary sodium intake in patients with postural tachycardia syndrome. Journal of the American College of Cardiology 77(17):2174-2184.

Glaser, C. A., S. Honarmand, L. J. Anderson, D. P. Schnurr, B. Forghani, C. K. Cossen, F. L. Schuster, L. J. Christie, and J. H. Tureen. 2006. Beyond viruses: Clinical profiles and etiologies associated with encephalitis. Clinical Infectious Diseases 43(12):1565-1577. https://doi.org/10.1086/509330. https://doi.org/10.1086/509330.

Gold, J. E., R. A. Okyay, W. E. Licht, and D. J. Hurley. 2021. Investigation of long COVID prevalence and its relationship to Epstein-Barr virus reactivation. Pathogens 10(6).

Grut, V., M. Biström, J. Salzer, P. Stridh, D. Jons, R. Gustafsson, A. Fogdell-Hahn, J. Huang, N. Brenner, J. Butt, N. Bender, A. Lindam, L. Alonso-Magdalena, M. Gunnarsson, M. Vrethem, T. Bergström, O. Andersen, I. Kockum, T. Waterboer, T. Olsson, and P. Sundström. 2021. Cytomegalovirus seropositivity is associated with reduced risk of multiple sclerosis—A presymptomatic case-control study. European Journal of Neurology 28(9):3072-3079.

Guo, C., X. Che, T. Briese, A. Ranjan, O. Allicock, R. A. Yates, A. Cheng, D. March, M. Hornig, A. L. Komaroff, S. Levine, L. Bateman, S. D. Vernon, N. G. Klimas, J. G. Montoya, D. L. Peterson, W. I. Lipkin, and B. L. Williams. 2023. Deficient butyrate-producing capacity in the gut microbiome is associated with bacterial network disturbances and fatigue symptoms in ME/CFS. Cell Host Microbe 31(2):288-304.e288.

Harrison, N. A., V. Voon, M. Cercignani, E. A. Cooper, M. Pessiglione, and H. D. Critchley. 2016. A neurocomputational account of how inflammation enhances sensitivity to punishments versus rewards. Biological Psychiatry 80(1):73-81. https://doi.org/https://doi.org/10.1016/j.biopsych.2015.07.018.

Hensley-McBain, T., and J. A. Manuzak. 2021. Zonulin as a biomerker and potential therapeutic target in multisystem inflammatory syndrome in children. The Journal of Clinical Investigation 131(14).

Hernández, S. A., K. Ogrinc, M. Korva, A. Kastrin, P. Bogovič, T. Rojko, K. W. Kelley, J. J. Weis, F. Strle, and K. Strle. 2023. Association of persistent symptoms after Lyme neuroborreliosis and increased levels of interferon-α in blood. Emerging Infectious Disease 29(6):1091-1101.

Hira, R., J. R. Baker, T. Siddiqui, S. I. Ranada, A. Soroush, K. Karalasingham, H. Ahmad, V. Mavai, L. M. Ayala Valani, S. Ambreen, K. M. Bourne, M. G. Lloyd, C. A. Morillo, R. S. Sheldon, and S. R. Raj. 2023. Objective hemodynamic cardiovascular autonomic abnormalities in post-acute sequelae of COVID-19. Canadian Journal of Cardiology 39(6):767-775. https://doi.org/10.1016/j.cjca.2022.12.002.

Hoad, A., G. Spickett, J. Elliott, and J. Newton. 2008. Postural orthostatic tachycardia syndrome is an under-recognized condition in chronic fatigue syndrome. QJM: An International Journal of Medicine 101(12):961-965. https://doi.org/10.1093/qjmed/hcn123.https://doi.org/10.1093/qjmed/hcn123.

Hook, S. A., S. Jeon, S. A. Niesobecki, A. P. Hansen, J. I. Meek, J. Bjork, and A. F. Hinckley. 2022. Economic burden of reported Lyme disease in high-incidence areas, United States, 2014–2016. Emerging Infectious Diseases 28(6):1170-1179. https://doi.org/10.3201/eid2806.211335.

Horwitz, R. I., A. Hayes-Conroy, B. H. Singer, M. R. Cullen, K. Badal, and I. Sim. 2022. Falling down the biological rabbit hole: Epstein-Barr virus, biography, and multiple sclerosis. The Journal of Clinical Investigation 132(17). https://doi.org/10.1172/JCI164141.

Hrvatin, S., S. Sun, O. F. Wilcox, H. Yao, A. J. Lavin-Peter, M. Cicconet, E. G. Assad, M. E. Palmer, S. Aronson, A. S. Banks, E. C. Griffith, and M. E. Greenberg. 2020. Neurons that regulate mouse torpor. Nature 583:115-121.

Ilanges, A. R. Shiao, J. Shaked, J. Luo, X. Yu, and J. M. Friedman. 2022. Brainstem ADCYAP1⁺ neurons control multiple aspects of sickness behaviour. Nature 609:761-771.

IOM (Institute of Medicine). 2015. Beyond myalgic encephalomyelitis/chronic fatigue syndrome: Redefining an illness. Washington, DC: The National Academies Press. https://doi.org/10.17226/19012.

Jacek, E., B. A. Fallon, A. Chandra, M. K. Crow, G. P. Wormser, and A. Alaedini. 2013. Increased IFNα activity and differential antibody response in patients with a history of Lyme disease and persistent cognitive deficits. Journal of Neuroimmunology 255(1-2):85-91.

Jain, S., W. H. Self, R. G. Wunderink, S. Fakhran, R. Balk, A. M. Bramley, C. Reed, C. G. Grijalva, E. J. Anderson, D. M. Courtney, J. D. Chappell, C. Qi, E. M. Hart, F. Carroll, C. Trabue, H. K. Donnelly, D. J. Williams, Y. Zhu, S. R. Arnold, K. Ampofo, G. W. Waterer, M. Levine, S. Lindstrom, J. M. Winchell, J. M. Katz, D. Erdman, E. Schneider, L. A. Hicks, J. A. McCullers, A. T. Pavia, K. M. Edwards, and L. Finelli. 2015. Community-acquired pneumonia requiring hospitalization among U.S. adults. New England Journal of Medicine 373(5):415-427. https://doi.org/10.1056/NEJMoa1500245.

Jason, L. A., M. C. Benton, L. Valentine, A. Johnson, and S. Torres-Harding. 2008. The economic impact of ME/CFS: Individual and societal costs. Dynamic Medicine 7:6. https://doi.org/10.1186/1476-5918-7-6.

Kedor, C., H. Freitag, L. Meyer-Arndt, K. Wittke, L. G. Hanitsch, T. Zoller, F. Steinbeis, M. Haffke, G. Rudolf, B. Heidecker, T. Bobbert, J. Spranger, H.-D. Volk, C. Skurk, F. Konietschke, F. Paul, U. Behrends, J. Bellmann-Strobl, and C. Scheibenbogen. 2022. A prospective observational study of post-COVID-19 chronic fatigue syndrome following the first pandemic wave in Germany and biomarkers associated with symptom severity. Nature Communications 13(1):5104.

Kingery, J. R., M. M. Safford, P. Martin, J. D. Lau, M. Rajan, G. T. Wehmeyer, H. A. Li, M. N. Alshak, A. Jabri, A. Kofman, C. S. Babu, E. K. Benitez, F. Palacardo, I. G. Das, K. Kaylor, K. M. Woo, N. L. Roberts, S. Rahiel, V. Gali, L. Han, J. Lee, N. Roszkowska, Y. E. Kim, S. Bakshi, C. Hogan, M. McNairy, L. C. Pinheiro, and P. Goyal. 2022. Health status, persistent symptoms, and effort intolerance one year after acute COVID-19 infection. Journal of General Internal Medicine 37(5):1218-1225.

Klempner, M. S., L. T. Hu, J. Evans, C. H. Schmid, G. M. Johnson, R. P. Trevino, D. Norton, L. Levy, D. Wall, J. McCall, M. Kosinski, and A. Weinstein. 2001. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of lyme disease. New England Journal of Medicine 345:85-92.

Komaroff, A. L., and W. I. Lipkin. 2023. ME/CFS and long COVID share similar symptoms and biological abnormalities: Road map to the literature. Frontiers in Medicine (Lausanne) 10:1187163.

Krupp, L. B., L. G. Hyman, R. Grimson, P. K. Coyle, P. Melville, S. Ahnn, R. Dattwyler, and B. Chandler. 2003. Study and treatment of post lyme disease (STOP-LD): A randomized double masked clinical trial. Neurology 60(12).

Larsen, N. W., L. E. Stiles, and M. G. Miglis. 2021. Preparing for the long-haul: Autonomic complications of COVID-19. Autonomic Neuroscience 235:102841. https://doi.org/10.1016/j.autneu.2021.102841.

Larsen, N. W., L. E. Stiles, R. Shaik, L. Schneider, S. Muppidi, C. T. Tsui, L. N. Geng, H. Bonilla, and M. G. Miglis. 2022. Characterization of autonomic symptom burden in long COVID: A global survey of 2,314 adults. Frontiers in Neurology 13:1012668.

Laubscher, G. J., P. J. Lourens, C. Venter, D. B. Kell, and E. Pretorius. 2021. TEG®, microclot and platelet mapping for guiding early management of severe COVID-19 coagulopathy. Journal of Clinical Medicine 10(22):5381. https://www.mdpi.com/2077-0383/10/22/5381 (accessed October 17, 2023).

Levin, L. I., K. L. Munger, M. V. Rubertone, C. A. Peck, E. T. Lennette, D. Spiegelman, and A. Ascherio. 2005. Temporal relationship between elevation of Epstein-Barr virus antibody titers and initial onset of neurological symptoms in multiple sclerosis. JAMA 293(20):2496-2500. https://doi.org/10.1001/jama.293.20.2496.

Lowenstein, F. 2020. We need to talk about what Coronavirus recoveries look like. New York Times. https://www.nytimes.com/2020/04/13/opinion/coronavirus-recovery.html (accessed October 4, 2023).

Lucido, M. J., M. Bekhbat, D. R. Goldsmith, M. T. Treadway, E. Haroon, J. C. Felger, and A. H. Miller. 2021. Aiding and abetting anhedonia: Impact of inflammation on the brain and pharmacological implications. Pharmacology Review 73(3):1084-1117.

Mbala-Kingebeni, P., C. Pratt, M. Mutafali-Ruffin, M. G. Pauthner, F. Bile, A. Nkuba-Ndaye, A. Black, E. Kinganda-Lusamaki, M. Faye, A. Aziza, M. M. Diagne, D. Mukadi, B. White, J. Hadfield, K. Gangavarapu, N. Bisento, D. Kazadi, B. Nsunda, M. Akonga, O. Tshiani, J. Misasi, A. Ploquin, V. Epaso, E. Sana-Paka, Y. T. T. N’kasar, F. Mambu, F. Edidi, M. Matondo, J. Bula Bula, B. Diallo, M. Keita, M. R. D. Belizaire, I. S. Fall, A. Yam, S. Mulangu, A. W. Rimoin, E. Salfati, A. Torkamani, M. A. Suchard, I. Crozier, L. Hensley, A. Rambaut, O. Faye, A. Sall, N. J. Sullivan, T. Bedford, K. G. Andersen, M. R. Wiley, S. Ahuka-Mundeke, and J.-J. Muyembe Tamfum. 2021. Ebola virus transmission initiated by relapse of systemic ebola virus disease. New England Journal of Medicine 384(13):1240-1247.

Miglis, M. G., J. Seliger, R. Shaik, and C. H. Gibbons. 2022. A case series of cutaneous phosphorylated α-synuclein in Long-COVID POTS. Clinical Autonomic Research 32: 209-212.

Mouchati, C., J. C. Durieux, S. N. Zisis, D. Labbato, M. A. Rodgers, K. Ailstock, B. L. Reinert, N. T. Funderburg, and G. A. McComsey. 2023. Increase in gut permeability and oxidized LDL is associated with post-acute sequelae of SARS-CoV-2. Frontiers in Immunology 14:1182544.

Nittas, V., M. Gao, E. A. West, T. Ballouz, D. Menges, S. Wulf Hanson, and M. A. Puhan. 2022. Long COVID through a public health lens: An umbrella review. Public Health Reviews 43. https://doi.org/10.3389/phrs.2022.1604501.

Novak, P., S. S. Mukerji, H. S. Alabsi, D. Systrom, S. P. Marciano, D. Felsenstein, W. J. Mullally, and D. M. Pilgrim. 2022. Multisystem involvement in post-acute sequelae of coronavirus disease 19. Annals of Neurology 91(3):367-379. https://doi.org/10.1002/ana.26286.

Nystrom, S., and P. Hammarstrom. 2022. Amyloidogenesis of SARS-CoV-2 spike protein. Journal of the American Chemical Society 144(20):8945-8950. https://doi.org/10.1021/jacs.2c03925.

Paul, B. D., M. D. Lemle, A. L. Komaroff, and S. H. Snyder. 2021. Redox imbalance links COVID-19 and myalgic encephalomyelitis/chronic fatigue syndrome. Proceedings of the National Academy of Sciences 118(34):e2024358118.

Peluso, M. J., and S. G. Deeks. 2022. Early clues regarding the pathogenesis of long COVID. Trends in Immunology 43(4):268-270.

Peluso, M. J., M. A. Spinelli, T. M. Deveau, C. A. Forman, S. E. Munter, S. Mathur, A. F. Tang, S. Lu, S. A. Goldberg, M. I. Arreguin, R. Hoh, V. Tai, J. Y. Chen, E. O. Martinez, B. C. Yee, A. Chenna, J. W. Winslow, C. J. Petropoulos, A. Sette, D. Weiskopf, N. Kumar, K. L. Lynch, P. W. Hunt, M. S. Durstenfeld, P. Y. Hsue, J. D. Kelly, J. N. Martin, D. V. Glidden, M. Gandhi, S. G. Deeks, R. L. Rutishauser, and T. J. Henrich. 2022. Postacute sequelae and adaptive immune responses in people with HIV recovering from SARS-CoV-2 infection. AIDS 36(12):F7-f16.

Peluso, M. J., T.-M. Deveau, S. E. Munter, D. Ryder, A. Buck, G. Beck-Engeser, F. Chan, S. Lu, S. A. Goldberg, R. Hoh, V. Tai, L. Torres, N. S. Iyer, M. Deswal, L. H. Ngo, M. Buitrago, A. Rodriguez, J. Y. Chen, B. C. Yee, A. Chenna, J. W. Winslow, C. J. Petropoulos, A. N. Deitchman, J. Hellmuth, M. A. Spinelli, M. S. Durstenfeld, P. Y. Hsue, J. D. Kelly, J. N. Martin, S. G. Deeks, P. W. Hunt, and T. J. Henrich. 2023a. Chronic viral coinfections differentially affect the likelihood of developing long COVID. Journal of Clinical Investigation 133(3).

Peluso, M. J., H. Pickering, F. Chan, G. C. Ambayec, G. Beck-Engeser, K. Wick, M. Matthay, C. Calfee, J. Martin, S. G. Deeks, S. Iyer, H. Maecker, T. Henrich, E. F. Reed, and P. W. Hunt. 2023b. Differential association of cytomegalovirus with acute and post-acute COVID-19. Paper presented at Conference on Retroviruses and Opportunistic Infections, Seattle, WA.

Pollack, B., E. von Saltza, L. McCorkell, L. Santos, A. Hultman, A. K. Cohen, and L. Soares. 2023. Female reproductive health impacts of long COVID and associated illnesses including ME/CFS, POTS, and connective tissue disorders: A literature review. Frontiers in Rehabilitation Sciences 4:1122673.

Porritt, R. A., A. Binek, L. Paschold, M. N. Rivas, A. McArdle, L. M. Yonker, G. Alter, H. K. Chandnani, M. Lopez, A. Fasano, J. E. Van Eyk, M. Binder, and M. Arditi. 2021. The autoimmune signature of hyperinflammatory syndrome in children. Journal of Clinical Investigation 131(20).

Pretorius, E., M. Vlok, C. Venter, J. A. Bezuidenhout, G. J. Laubscher, J. Steenkamp, and D. B. Kell. 2021. Persistent clotting protein pathology in Long COVID/post-acute sequelae of COVID-19 (PASC) is accompanied by increased levels of antiplasmin. Cardiovascular Diabetology 20(1):172. https://doi.org/10.1186/s12933-021-01359-7.

Round, J. L., and S. K. Mazmanian. 2009. The gut microbiota shapes intestinal immune responses during health and disease. Nature Reviews Immunology 9(5):313-323.

Schneider-Hohendorf, T., L. A. Gerdes, B. Pignolet, R. Gittelman, P. Ostkamp, F. Rubelt, C. Raposo, B. Tackenberg, M. Riepenhausen, C. Janoschka, C. Wünsch, F. Bucciarelli, A. Flierl-Hecht, E. Beltrán, T. Kümpfel, K. Anslinger, C. C. Gross, H. Chapman, I. Kaplan, D. Brassat, H. Wekerle, M. Kerschensteiner, L. Klotz, J. D. Lünemann, R. Hohlfeld, R. Liblau, H. Wiendl, and N. Schwab. 2022. Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis. Journal of Experimental Medicine 219(11).

Schutzer, S. E., T. E. Angel, T. Liu, A. A. Schepmoes, T. R. Clauss, J. N. Adkins, D. G. Camp, II, B. K. Holland, J. Bergquist, P. K. Coyle, R. D. Smith, B. A. Fallon, and B. H. Natelson. 2011. Distinct cerebrospinal fluid proteomes differentiate post-treatment Lyme disease from chronic fatigue syndrome. PLOS ONE 6(2):e17287.

Servellita, V., J. Bouquet, A. Rebman, T. Yang, E. Samayoa, S. Miller, M. Stone, M. Lanteri, M. Busch, P. Tang, M. Morshed, M. J. Soloski, J. Aucott, and C. Y. Chiu. 2022. A diagnostic classifier for gene expression-based identification of early Lyme disease. Nature Communications Medicine 2(92).

Sotzny, F., I. S. Filgueiras, C. Kedor, H. Freitag, K. Wittke, S. Bauer, N. Sepúlveda, D. L. Mathias da Fonseca, G. C. Baiocchi, A. H. C. Marques, M. Kim, T. Lange, D. R. Plaça, F. Luebber, F. M. Paulus, R. De Vito, I. Jurisica, K. Schulze-Forster, F. Paul, J. Bellmann-Strobl, R. Rust, U. Hoppmann, Y. Shoenfeld, G. Riemekasten, H. Heidecke, O. Cabral-Marques, and C. Scheibenbogen. 2022. Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in post COVID syndrome correlate with symptom severity. Frontiers in Immunology 13:981532.

Stein, S. R., S. C. Ramelli, A. Grazioli, J.-Y. Chung, M. Singh, C. K. Yinda, C. W. Winkler, J. Sun, J. M. Dickey, K. Ylaya, S. H. Ko, A. P. Platt, P. D. Burbelo, M. Quezado, S. Pittaluga, M. Purcell, V. J. Munster, F. Belinky, M. J. Ramos-Benitez, E. A. Boritz, I. A. Lach, D. L. Herr, J. Rabin, K. K. Saharia, R. J. Madathil, A. Tabatabai, S. Soherwardi, M. T. McCurdy, A. L. Babyak, L. J. Perez Valencia, S. J. Curran, M. E. Richert, W. J. Young, S. P. Young, B. Gasmi, M. Sampaio De Melo, S. Desar, S. Tadros, N. Nasir, X. Jin, S. Rajan, E. Dikoglu, N. Ozkaya, G. Smith, E. R. Emanuel, B. L. Kelsall, J. A. Olivera, M. Blawas, R. A. Star, N. Hays, S. Singireddy, J. Wu, K. Raja, R. Curto, J. E. Chung, A. J. Borth, K. A. Bowers, A. M. Weichold, P. A. Minor, M. A. N. Moshref, E. E. Kelly, M. M. Sajadi, T. M. Scalea, D. Tran, S. Dahi, K. B. Deatrick, E. M. Krause, J. A. Herrold, E. S.

Wiedemann, A., E. Foucat, H. Hocini, C. Lefebvre, B. P. Hejblum, M. Durand, M. Krüger, A. K. Keita, A. Ayouba, S. Mély, J.-C. Fernandez, A. Touré, S. Fourati, C. Lévy-Marchal, H. Raoul, E. Delaporte, L. Koivogui, R. Thiébaut, C. Lacabaratz, Y. Lévy, A. Ayouba, E. Delaporte, A. K. Keita, L. Koivogui, C. Lacabaratz, C. L. Marchal, Y. Levy, H. Raoul, A. Touré, and G. PostEboGui Study. 2020. Long-lasting severe immune dysfunction in ebola virus disease survivors. Nature Communications 11(1):3730.

Wilson, M. R., H. A. Sample, K. C. Zorn, S. Arevalo, G. Yu, J. Neuhaus, S. Federman, D. Stryke, B. Briggs, C. Langelier, A. Berger, V. Douglas, S. A. Josephson, F. C. Chow, B. D. Fulton, J. L. DeRisi, J. M. Gelfand, S. N. Naccache, J. Bender, J. Dien Bard, J. Murkey, M. Carlson, P. M. Vespa, T. Vijayan, P. R. Allyn, S. Campeau, R. M. Humphries, J. D. Klausner, C. D. Ganzon, F. Memar, N. A. Ocampo, L. L. Zimmermann, S. H. Cohen, C. R. Polage, R. L. DeBiasi, B. Haller, R. Dallas, G. Maron, R. Hayden, K. Messacar, S. R. Dominguez, S. Miller, and C. Y. Chiu. 2019. Clinical metagenomic sequencing for diagnosis of meningitis and encephalitis. New England Journal of Medicine 380(24):2327-2340.

Wong, T. L., and D. J. Weitzer. 2021. Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)—A systemic review and comparison of clinical presentation and symptomatology. Medicina (Kaunas) 57(5).

Yonker, L. M., T. Gilboa, A. F. Ogata, Y. Senussi, R. Lazarovits, B. P. Boribong, Y. C. Bartsch, M. Loiselle, M. N. Rivas, R. A. Porritt, R. Lima, J. P. Davis, E. J. Farkas, M. D. Burns, N. Young, V. S. Mahajan, S. Hajizadeh, X. I. H. Lopez, J. Kreuzer, R. Morris, E. E. Martinez, I. Han, K. Griswold, Jr., N. C. Barry, D. B. Thompson, G. Church, A. G. Edlow, W. Haas, S. Pillai, M. Arditi, G. Alter, D. R. Walt, and A. Fasano. 2021. Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier. Journal of Clinical Investigation 131(14).

Yonker, L. M., Z. Swank, T. Gilboa, Y. Senussi, V. Kenyon, L. Papadakis, B. P. Boribong, R. W. Carroll, D. R. Walt, and A. Fasano. 2022. Zonulin antagonist, larazotide (AT1001), as an adjuvant treatment for multisystem inflammatory syndrome in children: A case series. Critical Care Explorations 10(2).

Zheng, Y. B., N. Zeng, K. Yuan, S. S. Tian, Y. B. Yang, N. Gao, X. Chen, A. Y. Zhang, A. L. Kondratiuk, P. P. Shi, F. Zhang, J. Sun, J. L. Yue, X. Lin, L. Shi, A. Lalvani, J. Shi, Y. P. Bao, and L. Lu. 2023. Prevalence and risk factor for long COVID in children and adolescents: A meta-analysis and systematic review. Journal of Infection and Public Health 16(5):660-672.