Suggested Citation:
"APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press.
doi: 10.17226/28669.
EPIGENETICS: Plays an important role in understanding climate change and health, with environmental changes impacting health outcomes and the way genes are expressed.
CLIMATE MIGRATION: Prioritize research on climate-driven migration and its impacts, improve knowledge translation from research to policy, and address mental health effects of climate change.
IMPLEMENTATION RESEARCH: Implementation research as an evaluation context, piloting within a local context, evidence from the community perspective.
MEASURE INDIVIDUAL EXPOSURE AND RESPONSE: Low-tech wearables, epigenetic age acceleration, and pre-clinical models using human-relevant exposure.
BUILDING CAPACITY AND PARTNERSHIPS with local researchers, community engagement, technology and knowledge transfer, and investing in people.
MENTAL HEALTH among children and adolescents, and the social, political, and commercial determinants of climate change impact the physical and mental health of children.
EXPOSOME RESEARCH: Trying to the totality of exposures that are influencing health.
Suggested Citation:
"APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press.
doi: 10.17226/28669.
UTILIZING AI FOR DATA SYNTHESIS and understanding public sources of information on climate and health.
BIOMARKER IDENTIFICATION: There is promise in the use of biomarker identification as they relate to climate change and its impacts on human health.
IMPLEMENTATION SCIENCE RESEARCH as it relates to educational resources pertaining to climate change, health, and equity.
IMPACTS ON AIR QUALITY
FRAMEWORKS ON PHYSICIAN ADVOCACY AND CLIMATE CHANGE
BASIC SCIENCE: Identification of preventative measures for extreme climate impacts on health and understanding the long-term effects autoimmune disorders, cardiovascular and reproductive health.
FRAMEWORKS FOR COMMUNITY INVOLVEMENT: Interdisciplinary collaboration, private-sector engagement, and building resilient health care systems with justice and equity at the forefront.
Suggested Citation:
"APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press.
doi: 10.17226/28669.
Suggested Citation:
"APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press.
doi: 10.17226/28669.
Climate change is a defining health challenge of the 21st century. Its impacts, from heat-related illness and extreme weather to food insecurity and mental health distress, are already affecting populations across the United States and globally. However, gaps in research, data, infrastructure, and public engagement hinder the nation's ability to respond effectively and equitably.
A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate outlines a bold vision to advance climate-health research. This agenda identifies key research domains including health impacts, adaptation and mitigation strategies, infrastructure and capacity building, and policy and public engagement. The publication provides actionable guidance to accelerate transdisciplinary science, inform evidence-based policy, and support community resilience, especially for those most vulnerable to climate threats.
National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press.
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