A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate (2025)

Chapter: APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)

Previous Chapter: APPENDIX B: KEY WORDS FROM LITERATURE SEARCH
Suggested Citation: "APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press. doi: 10.17226/28669.

APPENDIX C
RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)

  • EPIGENETICS: Plays an important role in understanding climate change and health, with environmental changes impacting health outcomes and the way genes are expressed.
  • CLIMATE MIGRATION: Prioritize research on climate-driven migration and its impacts, improve knowledge translation from research to policy, and address mental health effects of climate change.
  • IMPLEMENTATION RESEARCH: Implementation research as an evaluation context, piloting within a local context, evidence from the community perspective.
  • MEASURE INDIVIDUAL EXPOSURE AND RESPONSE: Low-tech wearables, epigenetic age acceleration, and pre-clinical models using human-relevant exposure.
  • BUILDING CAPACITY AND PARTNERSHIPS with local researchers, community engagement, technology and knowledge transfer, and investing in people.
  • MENTAL HEALTH among children and adolescents, and the social, political, and commercial determinants of climate change impact the physical and mental health of children.
  • EXPOSOME RESEARCH: Trying to the totality of exposures that are influencing health.
Suggested Citation: "APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press. doi: 10.17226/28669.
  • UTILIZING AI FOR DATA SYNTHESIS and understanding public sources of information on climate and health.
  • BIOMARKER IDENTIFICATION: There is promise in the use of biomarker identification as they relate to climate change and its impacts on human health.
  • IMPLEMENTATION SCIENCE RESEARCH as it relates to educational resources pertaining to climate change, health, and equity.
  • IMPACTS ON AIR QUALITY
  • FRAMEWORKS ON PHYSICIAN ADVOCACY AND CLIMATE CHANGE
  • BASIC SCIENCE: Identification of preventative measures for extreme climate impacts on health and understanding the long-term effects autoimmune disorders, cardiovascular and reproductive health.
  • FRAMEWORKS FOR COMMUNITY INVOLVEMENT: Interdisciplinary collaboration, private-sector engagement, and building resilient health care systems with justice and equity at the forefront.

Suggested Citation: "APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press. doi: 10.17226/28669.
Page 67
Suggested Citation: "APPENDIX C: RESEARCH GAPS IDENTIFIED IN PHASES 1 AND 2 (INTERVIEW SYNTHESIS AND LITERATURE SEARCH)." National Academy of Medicine. 2025. A Research Agenda to Protect Human Health and Build Resilience in the Face of a Changing Climate. Washington, DC: The National Academies Press. doi: 10.17226/28669.
Page 68
Next Chapter: APPENDIX D: SURVEY QUESTIONS
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