A committee of the National Research Council will review the scientific evidence on associations between adverse health effects and historical data on prenatal, childhood, and adult exposures to contaminated drinking water at Camp Lejeune, North Carolina. The committee will assess the strength of evidence in establishing a link or association between exposure to trichloroethylene, tetrachloroethylene, and other drinking water contaminants and each adverse health effect suspected to be associated with such exposure. For each health effect reviewed, the committee will determine to the extent practicable with the available scientific data (1) whether a statistical association between such contaminant exposures and the health effect exists, (2) whether there exist plausible biological mechanisms or other evidence of a causal relationship between contaminant exposures and the effect, (3) the strength of evidence for causal inference for each of the health effects, and (4) other scientific considerations that may help the Department of the Navy prioritize future activities. The committee's review will include an evaluation of the toxicologic and epidemiologic literature on adverse health effects of trichloroethylene and tetrachloroethylene, including studies of populations exposed to similar levels of the contaminants of concerns; risk assessment reports from government agencies; recent literature reviews by the National Research Council, Institute of Medicine and other groups; completed and ongoing ATSDR studies at Camp Lejeune; and published meta-analyses.In the evaluation of previous and current health studies of residents of Camp Lejeune, the committee will review the appropriateness of the study question, design, analysis, results, and conclusions.Sponsor: Department of DefenseStarting date: 04/10/07A final report will be issued at the end of the project in approximately 18 months.Note: The project duration has been extended. The report is expected to be issued mid 2009.