Completed
This 2015 workshop featured presentations and panel discussions examining the role pets with naturally occurring tumors can play in the translation of veterinary cancer research to human cancer research. Workshop participants discussed the rationale and potential for integrating clinical trials for pets with into translational cancer research and drug development. Topics included: strategies to support the incorporation of data from veterinary cancer trials in drug development pathways, gaps in the evidence base to support integration of such trials, and challenges and potential solutions to greater integration of such trials.
Featured publication
Workshop
·2015
Traditional preclinical mouse models of cancer have been very useful for studying the biology of cancer, however they often lack key characteristics of human cancers. As a result, many novel drug candidates fail in human clinical trials despite evidence of drug efficacy in those preclinical models....
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Description
An ad hoc committee will plan and host a 1.5-day public workshop that will feature invited presentations and panel discussions. Workshop participants will examine the rationale and potential for integrating clinical trials for pets with naturally occurring cancer into translational cancer research and drug development. Participants will be invited to discuss topics that may include:
· An overview of the limitations of current preclinical oncology models and resulting late-stage drug development failures and costs;
· Strategies to support the incorporation of data from clinical trials for pets with cancer in drug development pathways;
· Gaps in the evidence base to support integration of such trials in the drug development continuum and ways to address those gaps;
· Challenges and potential solutions to greater integration of such trials in cancer drug development pathways; and
· Opportunities for further collaborations and information exchange between human and veterinary oncologists.
The committee will develop the agenda for the workshop sessions, select and invite speakers and discussants, and moderate the discussions. An individually-authored workshop summary of the presentations and discussions at the workshopwill be prepared by a designated rapporteur based on the information gathered and the discussions held during the workshop in accordance with institutional guidelines.
Collaborators
Sponsors
Animal Cancer Foundation
College of Veterinary Medicine at North Carolina State University
Cornell University School of Veterinary Medicine
Flint Animal Cancer Center, Colorado State University
Ohio State University School of Veterinary Medicine
Purdue University College of Veterinary Medicine and the Center for Cancer Research
The Morris Animal Foundation
The Skippy Frank Translational Medicine and Life Sciences Fund
The University of California, Davis, School of Veterinary Medicine
The University of Colorado Cancer Center
The University of Florida College of Veterinary Medicine
The University of Georgia College of Veterinary Medicine
The University of Illinois College of Veterinary Medicine
The University of Minnesota College of Veterinary Medicine
The University of Missouri College of Veterinary Medicine and the Ellis Fischel Cancer Center
The University of Pennsylvania
The University of Wisconsin–Madison Carbone Cancer Center
The University of Wisconsin–Madison Institute for Clinical and Translational Research
The University of Wisconsin–Madison School of Veterinary Medicine
The Washington State University College of Veterinary Medicine
Staff
Sharyl Nass
Lead
Patrick Burke
Erin Balogh
Cyndi Trang
Major units and sub-units
Center for Health, People, and Places
Lead
Health and Medicine Division
Lead
Institute of Medicine
Lead
Board on Health Care Services
Lead
Health Care and Public Health Program Area
Lead
