An ad hoc planning committee will plan and host a two-day public workshop to explore opportunities to hasten the pathway from discovery to approval of new therapeutics for nervous system disorders. The workshop will feature invited presentations of new and emerging technologies and allow for interactive discussions around potential challenges.

Participants will be specifically invited to:

• Examine opportunities and challenges in neuroscience research for facilitating faster entry of potential treatments into first-in-human trials.

o Identify avenues for moving directly from cellular models to human trials minimizing the need for animal models to test efficacy

• Discuss the potential usefulness of new neuroscience technologies and techniques that would hasten the translation of research and facilitate the jump from cellular models to first-in-human trials (e.g. iPSCs, in vitro neuronal circuits, connectomics, brain imaging, etc.)

• Consider mechanisms of the regulatory review process which may facilitate faster entry of potential treatments into first-in-human trials.

o Explore the role of alternative tools, methods and approaches for validation (e.g. surrogate models)

• Consider mechanisms for integration and proliferation of new technologies and techniques to the broader neuroscience research community

An individually authored workshop summary will be prepared by a designated rapporteur based on the information gathered and the discussions held during the workshop in accordance with institutional policy and procedures.