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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)

Chapter: K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

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Suggested Citation: "K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994." Institute of Medicine. 1998. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Washington, DC: The National Academies Press. doi: 10.17226/6015.

K
Blood Concentrations of Folate and Vitamin B₁₂ from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

TABLE K-1 Serum Folate (ng/mL) of Persons Aged 4 Years and Older: Mean and Selected Percentiles, United States, 1988–1994

Gender and Age (y)	Number of Examined Persons	Mean	Standard Error of the Mean
Both, 4–8	3,128	11.0	0.3
M, 9–13	1,129	9.0	0.3
M, 14–18	865	6.0	0.4
M, 19–30	1,856	5.0	0.1
Males, 31–50	2,493	5.7	0.2
M, 51–70	1,987	7.4	0.2
M, >70	1,370	9.0	0.3
F, 9–13	1,149	8.2	0.3
F, 14–18	936	5.7	0.2
F, 19–30	1,915	5.8	0.2
F, 31–50	2,929	6.5	0.2
F, 51–70	2,087	8.9	0.3
F, >70	1,534	10.7	0.4
Pregnant F, 14–55	327	10.5	0.8
Both, ≥4, unadjusted	23,705	7.2	0.1
NOTE: Values have been adjusted by following recommendations in Life Sciences Research Office/Federation of American Societies for Experimental Biology. 1994. Assessment of the Folate Methodology Used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). Raiten DJ, Fisher KD, eds. Bethesda, MD: LSRO/ FASEB. Values are presented as received from source.

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Selected Percentiles
5th	10th	15th	25th	50th	75th	85th	90th	95th
4.4	5.3	5.9	6.9	9.4	12.8	14.9	16.9	21.8
3.4	4.0	4.8	5.6	7.7	10.9	12.8	15.3	18.1
2.3	2.6	2.9	3.4	4.7	7.4	8.7	10.5	13.2
1.8	2.2	2.5	2.9	4.0	6.2	7.7	8.7	11.1
1.9	2.3	2.7	3.2	4.6	7.1	9.2	10.5	12.8
2.2	2.7	3.0	3.7	5.7	9.3	12.0	14.3	17.8
2.3	3.1	3.6	4.5	6.9	11.1	15.3	17.9	21.7
3.1	3.8	4.0	4.9	6.8	10.3	11.6	13.9	17.8
2.1	2.5	2.7	3.2	4.9	7.2	8.7	9.7	12.1
1.8	2.3	2.5	3.1	4.6	7.2	9.0	10.5	13.1
1.9	2.3	2.7	3.3	4.9	8.2	10.6	12.4	16.0
2.4	2.9	3.3	4.2	6.6	11.4	14.6	17.0	22.2
2.9	3.6	4.0	5.1	8.0	13.7	17.5	20.6	26.6
2.7^a	3.4	3.7	4.7	8.4	13.9	16.6	18.5	20.5^a
2.1	2.5	2.9	3.6	5.5	9.0	11.4	13.5	17.2
^a Value does not meet standard of reliability or precision. SOURCE: NHANES III, 1988–1994, unpublished data, C.L.Johnson and J.D.Wright, National Center for Health Statistics, Centers for Disease Control and Prevention, 1997.

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TABLE K-2 Erythrocyte Folate (ng/mL) of Persons Aged 4 Years and Older: Mean and Selected Percentiles, United States, 1988–1994

Gender and Age (y)	Number of Examined Persons	Mean	Standard Error of the Mean
Both, 4–8	3,157	222	12.6
M, 9–13	1,137	202	4.2
M, 14–18	864	164	4.4
M, 19–30	1,853	164	2.8
M, 31–50	2,484	182	3.0
M, 51–70	1,968	216	4.5
M, >70	1,266	242	7.3
F, 9–13	1,145	175	3.4
F, 14–18	934	157	4.0
F, 19–30	1,917	168	3.3
F, 31–50	2,924	194	3.4
F, 51–70	2,059	238	5.5
F, >70	1,374	259	7.3
Pregnant F, 14–55	322	261	12.5
Both, ≥4, unadjusted	23,404	197	1.2
NOTE: Values have been adjusted by following recommendations in Life Sciences Research Office/Federation of American Societies for Experimental Biology. 1994. Assessment of the Folate Methodology Used in the Third National Health and Nutrition Examination Survey (NHANES III, 1988–1994). Raiten DJ, Fisher KD, eds. Bethesda, MD: LSRO/ FASEB. Values are presented as received from source.

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Selected Percentiles
5th	10th	15th	25th	50th	75th	85th	90th	95th
123	140	151	170	212	258	289	312	359
102	116	129	149	190	242	280	306	342
83	94	101	116	149	197	237	261	301
84	95	107	119	151	192	219	244	300
86	102	112	127	166	217	255	282	335
93	108	120	139	188	269	318	353	425
93	113	125	149	207	305	362	419	471
87	104	113	129	167	216	239	260	288
77	89	98	115	141	190	221	240	269
77	88	97	116	149	206	242	270	315
84	97	107	125	172	239	286	324	369
95	113	128	149	206	296	356	408	462
96	116	133	160	228	325	391	432	519
114^a	123	140	164	248	344	379	429	461^a
87	101	113	130	175	238	284	319	380
^a Value does not meet standard of reliability or precision. SOURCE: NHANES III, 1988–1994, unpublished data, C.L.Johnson and J.D.Wright, National Center for Health Statistics, Centers for Disease Control and Prevention, 1997.

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TABLE K-3 Serum Vitamin B₁₂ (pg/mL) of Persons Aged 4 Years and Older: Mean and Selected Percentiles, United States, 1991–1994

Gender and Age (y)	Number of Examined Persons	Mean	Standard Error of the Mean
Both, 4–8	1,519	781	13.2
M, 9–13	550	620	12.7
M, 14–18	458	516	14.0
M, 19–30	891	470	8.1
M, 31–50	1,201	473	8.4
M, 51–70	937	460	23.7
M, >70	614	449	21.0
F, 9–13	595	612	13.6
F, 14–18	496	509	14.6
F, 19–30	1,049	479	42.1
F, 31–50	1,639	497	42.8
F, 51–70	1,078	504	12.7
F, >70	824	536	66.1
Pregnant F, 14–55	173	426	53.1
Both, ≥4, unadjusted	12,024	517	9.0
NOTE: Values are presented as received from source. ^a Value does not meet standard of reliability or precision.

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Selected Percentiles
5th	10th	15th	25th	50th	75th	85th	90th	95th
409	474	517	569	720	909	1,034	1,103	1,270
344	379	420	470	590	746	825	868	947
261	335	344	395	485	589	656	767	871
251	281	312	355	466	550	623	666	762
236	287	305	348	436	556	633	681	803
190	247	273	317	414	540	630	688	884
187	218	239	298	382	512	629	719	881
344	383	401	453	569	694	794	880	1,060
276	300	319	362	460	618	733	791	871
214	250	277	328	437	580	669	721	805
223	262	287	332	427	589	666	729	827
224	266	291	344	465	605	698	769	919
186	232	261	315	436	622	718	795	953
232^a	246	255	293	421	501	549	579	631^a
233	274	303	351	466	615	707	790	924
SOURCE: NHANES III, 1988–1994, unpublished data, C.L.Johnson and J.D.Wright, National Center for Health Statistics, Centers for Disease Control and Prevention, 1997.

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TABLE K-4 Serum Homocysteine (µmol/L) of Persons Aged 12 Years and Older: Mean and Selected Percentiles, United States, 1991–1994

Gender and Age (y)	Number of Examined Persons	Mean	Standard Error of the Mean
M, 12–13	177	6.61	0.20
M, 14–18	395	8.39	0.34
M, 19–30	816	10.29	0.26
M, 31–50	1,055	9.93	0.20
M, 51–70	821	11.94	0.49
M, >70	502	13.40	0.49
F, 12–13	226	6.19	0.22
F, 14–18	448	7.08	0.19
F, 19–30	938	8.05	0.15
F, 31–50	1,446	8.36	0.16
F, 51–70	937	9.68	0.19
F, >70	681	11.83	0.36
Pregnant F, 14–55	143	5.41	0.36
Both, ≥12, unadjusted	8,585	9.51	0.09
^a Value does not meet standard of reliability or precision. SOURCE: NHANES III, 1988–1994, unpublished data, C.L.Johnson and J.D.Wright, National Center for Health Statistics, Centers for Disease Control and Prevention, 1997.

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Selected Percentiles
5th	10th	15th	25th	50th	75th	85th	90th	95th
3.90^a	4.40	4.80	5.30	16.50	7.70	8.59	8.61	9.51^a
4.80	5.40	5.60	6.20	7.40	9.01	9.81	11.60	15.30
5.70	6.40	6.80	7.60	9.20	11.20	12.90	13.90	17.53
6.00	6.40	6.80	7.70	9.00	10.89	12.60	13.90	16.38
6.40	7.40	7.80	8.51	10.20	12.89	13.90	15.30	18.38
6.80	7.90	8.40	9.31	12.11	15.70	17.72	19.01	22.70
3.40^a	3.70	4.30	4.70	5.80	7.20	7.91	8.51	9.51^a
3.50	4.20	4.90	5.60	6.50	7.90	9.01	9.90	12.10
4.70	5.10	5.40	5.90	7.20	9.40	11.10	12.20	14.09
4.50	5.09	5.50	6.10	7.50	9.20	10.91	12.40	14.30
5.20	5.70	6.30	7.40	8.90	11.01	12.80	14.10	16.01
6.40	7.01	7.50	8.40	10.61	13.40	15.31	17.30	20.53
2.80^a	2.80^a	3.50	3.50	4.90	6.40	7.30	7.80^a	9.30^a
4.90	5.50	6.00	6.70	8.51	10.81	12.60	13.90	16.51

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Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (1998)

Chapter: K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

K Blood Concentrations of Folate and Vitamin B12 from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994

K
Blood Concentrations of Folate and Vitamin B₁₂ from the Third National Health and Nutrition Examination Survey (NHANES III), 1988–1994