Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons: HFC-236fa, HFC-23,and HFC-404a (2000)

Chapter: Toxicokinetics

Visit NAP.edu/10766 to get more information about this book, to buy it in print, or to download it as a free PDF.
Previous Chapter: 4 Hydrofluorocarbon-404a
Page 41 Cite Bookmark
Suggested Citation: "Toxicokinetics." National Research Council. 2000. Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons: HFC-236fa, HFC-23,and HFC-404a. Washington, DC: The National Academies Press. doi: 10.17226/9815.
Save
Cancel

HFC-143a

Chemical and Physical Properties

Common name:

HFC-143a

Chemical name:

1,1,1-Trifluoroethane

Synonyms:

FC-143a; hydrofluorocarbon 143a

CAS number:

420-46-6

Structural formula:

CH3CF3

Description:

Colorless gas

Molecular weight:

84.04

Boiling point:

-47.3°C at 760 mm Hg

Melting point:

-111.3°C

Flash point and flammability:

-90°C

Solubility:

Soluble in chloroform and ether

Auto-ignition:

750°C

Conversion factors:

1 ppm = 3.40 mg/m3;

1 mg/m3 = 0.29 ppm
Toxicokinetics

In a study of rats exposed by inhalation to HFC-143a at 4,800 ppm for 4-5 hr, 2,2,2-trifluoroethanol was the only metabolite detected. Nuclear magnetic resonance showed that HFC-143a was metabolized slowly, primarily through an oxidative route (DuPont 1994, as cited in AIHA 1996).

Page 41 Cite Bookmark
Suggested Citation: "Toxicokinetics." National Research Council. 2000. Submarine Exposure Guidance Levels for Selected Hydrofluorocarbons: HFC-236fa, HFC-23,and HFC-404a. Washington, DC: The National Academies Press. doi: 10.17226/9815.
Save
Cancel
Page 41
Next Chapter: Subchronic Toxicity
Subscribe to Email from the National Academies
Keep up with all of the activities, publications, and events by subscribing to free updates by email.