HYDROFLUOROCARBON (HFC)-236FA, or 1,1,1,3,3,3-hexafluoropropane, is a gaseous halocarbon that is being considered as a replacement for the refrigerant chlorofluorocarbon (CFC)-114, which is used in centrifugal chillers aboard U.S. Navy submarines. To protect submariners from large accidental releases or low-level slow leaks of HFC-236fa, emergency exposure guidance levels (EEGLs) and continuous exposure guidance levels (CEGLs) are needed to avoid adverse health effects from short-term or prolonged exposures to HFC-236fa and to avoid degradation in crew performance. This chapter presents the available toxicity information on HFC-236fa and the subcommittee's evaluation of the Navy's proposed 1-hr and 24-hr EEGLs and 90-day CEGL.