Established in 2019, the Roundtable on Black Men and Black Women in Science, Engineering, and Medicine (SEM) convenes a broad array of stakeholders that focus on the barriers and opportunities encountered by Black men and Black women as they navigate the pathways from K-12 and postsecondary education to careers in SEM. Through meetings, public workshops, and publications, the Roundtable advances discussions that highlight promising practices for increasing the representation, retention and inclusiveness of Black men and Black women in SEM.