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A committee of the National Research Council (NRC) will conduct a two-part study to assess and advance current approaches to toxicity testing and assessment to meet regulatory data needs. In the first part of the study, the committee will prepare a report reviewing selected aspects of several relevant reports by EPA and others on this topic. In the second part of the study, the committee will prepare a second report presenting a long-range vision and strategic plan for advancing the practices of toxicity testing and human health assessment for environmental contaminants.
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Consensus
·2007
Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the sta...
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Description
A committee of the National Research Council (NRC) will conduct a two-part study to assess and advance current approaches to toxicity testing and assessment to meet regulatory data needs. In the first part of the study (12 months), the committee will prepare a report reviewing selected aspects of several relevant reports by EPA and others on this topic (see below). In the second part of the study (24 months), to be funded separately at the government's option, the committee will prepare a second report presenting a long-range vision and strategic plan for advancing the practices of toxicity testing and human health assessment for environmental contaminants (see below). In developing the vision and strategic plan, the committee will consider evolving regulatory data needs; current toxicity testing guidelines and standards used by EPA and other federal agencies; the use of emerging science and tools (e.g., genomics, proteomics, transgenics, bioinformatics, computational toxicology, in vitro testing, and other alternatives to animal testing); and the challenges of incorporating more complex understanding of toxicity (e.g., toxicokinetics, mechanisms of action, systems biology) into human health risk assessment.Sponsor: U.S. Environmental Protection AgencyApproximate starting date is March 1, 2004Note: The report on the first part of the study is expected to be issued in summer 2005. This will be followed by another report at the end of second part of the study.
Contributors
Committee
Chair
Member
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Committee Membership Roster Comments
NOTE: Effective 09/10/04 there has been a change in committee membership with the resignation of Dr. Joseph Rodricks and Dr. James Swenberg and the addition of a new committee member, Dr. Lauren Zeise.
Effective 09/28/04: There has been a change in the committee membership with the resignation of Dr. George Daston.
Effective 11/10/04 there has been a change to the committee membership with the addition of three new committee members, Dr. Kim Boekelheide, Dr, Karl Kelsey and Dr, George Lucier.
11/30/04: We deeply regret the recent death our dear friend and fellow committee member Dr. Herbert Rosenkranz.
10/07/05: There has been a change in the committee membership with the resignation of Dr. George Lucier.
Sponsors
EPA
Staff
Ellen Mantus
Lead
Major units and sub-units
Division on Earth and Life Studies
Lead
Board on Environmental Studies and Toxicology
Lead