The National Academies of Science, Engineering, and Medicine (NASEM) will convene an ad hoc planning committee of international scientists to develop a workshop series that discusses adaptation of existing frameworks for assessing and reducing dual-use potential of biological research to emerging biotechnology-related research and development efforts. The committee will engage early-career and established scientists in these workshops to: a) understand the complex interplay between dual-use risks and scientific progress (i.e., scientific benefit) for biotechnology-related research; b) explore the potential that knowledge, technologies and equipment, and materials of biotechnology-related research and development could be exploited; c) review existing frameworks and guidance for assessing and mitigating dual-use potential of biological research activities, including resources focused on responsible science and innovation; and d) discuss defined steps for assessing and mitigating exploitation of biotechnology-related research and development activities to enable scientific progress in a positive and peaceful manner. The key themes from the workshop series will be summarized in a Proceedings.