A planning committee of the National Academies of Sciences, Engineering, and Medicine will organize and conduct a one-day public workshop that brings together experts and key stakeholders from academia, government, industry, and non-profit organizations to explore emerging evidence regarding differences in transcriptomic abnormalities that occur in the brains of men versus women with a variety of brain disorders including depression, post-traumatic stress disorder, drug addiction, neurodegenerative conditions, and other brain disorders.
Invited presentations and discussions will be designed to:

• Review the landscape of emerging evidence regarding sex differences in transcriptomic abnormalities in a variety of brain disorders, and discuss how this can be used to advance understanding of brain disorder pathophysiology.
• Explore ramifications for therapeutic development for these disorders, including identification of new targets, implications for preclinical and clinical study design, regulatory considerations, and potential sex-specific treatments.
• Discuss open research questions and opportunities to move the field forward.

The planning committee will develop the agenda for the workshop, select and invite speakers and discussants, and moderate the discussions. A proceedings of the presentations and discussions at the workshop will be prepared by a designated rapporteur in accordance with institutional guidelines.