Preventing and Treating Dementia: Research Priorities to Accelerate Progress (2025)
Chapter: Appendix D: Public Meeting Agendas
Appendix D
Public Meeting Agendas
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
OCTOBER 2, 2023
Virtual
Purpose
- Conduct committee and staff introductions.
- Hold an open session to hear from NIH on its perspective of the Statement of Task.
- Receive public comments.
All times listed in Eastern Time
PUBLIC SESSION
Session I: Presentation of the Committee’s Charge
| 9:00 a.m. |
Welcome and Introductions for the Session
Tia Powell, Committee Chair |
| 9:10 a.m. |
Remarks from NIH Leadership
Richard Hodes, Director, NIA Walter Koroshetz, Director, NINDS |
| 9:20 a.m. |
Presentation of the Charge to the Committee
Melinda Kelley, Associate Director for Scientific Strategy, Innovation, and Management, NIA |
| 9:35 a.m. | Clarifying Questions on the Statement of Task |
| 10:00 a.m. | Break (15 min) |
PUBLIC SESSION
Session II: Discussion of Study Context
| 10:15 a.m. |
Overview of NIH AD/ADRD Strategic Planning Activities
Eliezer Masliah, Director of the Division of Neuroscience, NIA Suzana Petanceska, Director, Office for Strategic Development and Partnerships in the Division of Neuroscience, NIA Sara Dodson, Senior Science Policy Analyst, NINDS Lis Nielsen, Director, Division of Behavioral and Social Research, NIA |
| 11:00 a.m. | Committee Discussion |
| 11:45 a.m. | Opportunity for Public Comment and Questions (Slido) |
| 12:00 p.m. | Adjourn Open Session |
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
November 8, 2023
Virtual
Purpose
- Discuss strategies for identifying promising areas of research that have the potential to catalyze scientific breakthroughs or accelerate translation.
- Explore how the development of collaborative and interdisciplinary research efforts and other approaches can be employed to open new areas of knowledge.
All times listed in Eastern Time
PUBLIC SESSION
| 9:00 a.m. |
Welcome and Review of Session Objectives
Tia Powell, Committee Chair |
| 9:05 a.m. |
Remarks from Speakers
Katja Brose, Science Program Officer, Chan Zuckerberg Initiative Tyler Best, Senior Advisor, Advanced Research Projects Agency for Health |
| 9:35 a.m. | Committee Discussion |
| 10:00 a.m. | Adjourn Public Session |
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
The Keck Center, 500 Fifth Street, NW
Washington, DC 20001
JANUARY 16, 2024
Keck 100 and Virtual
Meeting Objectives
- Engage a diverse group of stakeholders in exploring promising areas of AD/ADRD research that may have the potential to catalyze further scientific breakthroughs or accelerate translation of discoveries to effective preventive and therapeutic interventions.
- Explore barriers to the advancement of AD/ADRD research and opportunities and tools to address these impediments to progress.
- Investigate successes and failures experienced in other biomedical research fields, and discuss how lessons learned from these experiences could be translated to the AD/ADRD research context.
| 8:30 a.m. |
Welcome and Review of Meeting Objectives
Tia Powell, Committee Chair |
OPEN SESSION
Session I: Envisioning the Future of AD/ADRD Research
Session Objectives
- Hear from funders of research aimed at preventing and treating AD/ADRD about their perspectives on future research priorities and infrastructural and technological barriers that limit progress in those priority research areas.
- Discuss opportunities to accelerate translation from basic to clinical research and catalyze advances in AD/ADRD prevention and treatment.
| 8:40 a.m. |
Overview of Session Objectives
Tia Powell, Committee Chair, Moderator |
| 8:45 a.m. |
Panelist Remarks
Maria Carrillo, Alzheimer’s Association Russ Paulsen, UsAgainstAlzheimer’s Meg Smith, Cure Alzheimer’s Fund Ian Kremer, LEAD Coalition |
| 9:25 a.m. | Committee Discussion |
OPEN SESSION
Session II: Lessons Learned from Successes and Failures in Other Fields
Session Objectives
- Explore the experiences in other research fields with learning from failure and opportunities to translate those lessons into successes.
- Examine the process by which research priorities evolved in other biomedical research fields over time, specific strategies used to accelerate and support translation, and efforts that were made to enhance diversity and inclusion in all aspects of research.
- Discuss the development of precision medicine approaches and the diversification of the therapeutic portfolio in the context of other diseases.
| 10:10 a.m. |
Overview of Session Objectives
Ken Ramos, Committee Member, Moderator |
| 10:15 a.m. |
Panelist Remarks
Emelia Benjamin, Boston University Laura Esserman, University of California, San Francisco |
| 10:35 a.m. | Committee Discussion |
| 11:10 a.m. | Break (10 min) |
OPEN SESSION
Session III: The Exposome and Risk and Protective Factors for AD/ADRD
Session Objectives
- Discuss modifiable risk and protective factors across diverse populations and implications for priority research on strategies for preventing and treating AD/ADRD.
- Elucidate priorities for research at the intersection of social determinants of health and AD/ADRD and how those may help to address existing disparities in AD/ADRD.
- Explore barriers and opportunities for the timely translation of knowledge on risk and protective factors to effective, accessible interventions.
| 11:20 a.m. |
Overview of Session Objectives
Maria Glymour, Committee Member, Moderator Pamela Lein, Committee Member, Moderator |
| 11:25 a.m. |
Presentations
Lisa Barnes, Rush University Gary Miller, Columbia University Maria Corrada, University of California, Irvine Margaret Pericak-Vance, University of Miami |
| 11:45 p.m. |
Discussant Perspectives and Committee Discussion Expert Discussants
Kirk Erickson, University of Pittsburgh Amy Kind, University of Wisconsin Gill Livingston, University College London Jennifer Weuve, Boston University |
| 12:45 p.m. | Lunch (45 min) |
OPEN SESSION
Session IV: Molecular and Cellular Mechanisms of Neurodegenerative Disease
Session Objectives
- Explore research priorities related to mechanistic hypotheses for AD/ADRD, including those that are shared across multiple forms of dementia and have great potential to illuminate the mechanistic underpinnings of brain health and disease and broaden approaches to AD/ADRD prevention and treatment.
- Discuss promising advances and remaining gaps in tools, technologies, and analytic methods needed to advance the identification of effective intervention strategies for AD/ADRD.
| 1:30 p.m. |
Overview of Session Objectives
Christian Behl, Committee Member, Moderator |
| 1:35 p.m. |
Opening Remarks
Zaven Khachaturian, Alzheimer’s & Dementia |
| 1:45 p.m. |
Panelist Remarks
Virginia Lee, University of Pennsylvania Bart de Strooper, UK Dementia Research Institute Jürgen Götz, University of Queensland Bruce Lamb, Indiana University Ameer Taha, University of California, Davis Ralph Nixon, New York University |
| 2:20 p.m. | Committee Discussion |
| 3:00 p.m. | Break (15 min) |
OPEN SESSION
Session V: Advancing Knowledge Across the Life Course
Session Objectives
- Identify gaps in existing cohorts (e.g., diversity of participants, lack of data on factors from earlier phases of life, cost), and discuss the importance of obtaining representative population samples from across the life course.
- Discuss opportunities for using unconventional markers and methods (e.g., digital phenotyping, plasma biomarkers, multiomics approaches) to expand understanding of the complexity of brain health and AD/ADRD disease over the life course and how these can be incorporated into longitudinal data collection efforts.
- Explore technological approaches to overcome existing infrastructure and resource barriers.
| 3:15 p.m. |
Overview of Session Objectives
Nilüfer Ertekin-Taner, Committee Member, Moderator Hector González, Committee Member, Moderator |
| 3:20 p.m. |
Panel Discussion with Committee
Laura Baker, Wake Forest University Dawn Mechanic-Hamilton, University of Pennsylvania Rachel Buckley, Harvard Medical School Sid O’Bryant, University of North Texas Goldie S. Byrd, Wake Forest University Mark Mapstone, University of California, Irvine |
| 4:10 p.m. | Adjourn Public Session |
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
JANUARY 17, 2024
Keck 100 and Virtual
OPEN SESSION
Day 2 Opening Remarks
| 8:30 a.m. |
Welcome
Tia Powell, Committee Chair |
| 8:35 a.m. |
The Fundamental Importance of Early and Accurate Diagnosis
Daniel Gibbs, author and neurologist living with dementia |
| 8:45 a.m. | Committee Q&A |
OPEN SESSION
Session VI: Unlocking Innovation to Aid Detection, Diagnosis, and Monitoring
Panel 1: Development and Use of Digital Technologies to Assess Human Health
Objectives:
- Explore opportunities and research priorities for the development and use of sensitive digital tools and unconventional biomarkers to catalyze advances in the monitoring of human brain health and the detection and diagnosis of AD/ADRD.
- Examine challenges and lessons learned from other fields/contexts related to the development and use of technology to assess and monitor human health.
- Discuss challenges related to the use of deep learning systems in biomedical research (e.g., black box effect).
| 8:50 a.m. |
Overview of Panel Objectives
Rhoda Au, Committee Member, Moderator |
| 8:55 a.m. |
Panelist Remarks
Yannis Paschalidis, Boston University Jeffrey Kaye, Oregon Health and Sciences University Diane Cook, Washington State University |
| 9:15 a.m. | Committee Discussion |
Panel 2: Considerations for the Implementation of Tools to Detect, Diagnose, and Monitor AD/ADRD
Objectives:
- Consider the real-world implementation needs for tools to monitor brain health and detect and diagnose AD/ADRD, considering how these needs might inform the design and function of tools and markers in the early stages of research and development.
- Explore lessons learned from successes and failures related to the global implementation of distinct tools and markers to predict and describe human brain health.
| 9:55 a.m. |
Overview of Panel Objectives
Chi Udeh-Momoh, Committee Member, Moderator |
| 10:00 a.m. |
Panelist Remarks
Niranjan Bose, Gates Ventures Agustín Ibáñez, Global Brain Health Institute Debby Tsuang, University of Washington Tim MacLeod, Davos Alzheimer’s Collaborative, Health System Preparedness David Cutler, Harvard University |
| 10:25 a.m. | Committee Discussion |
| 10:55 a.m. | Break (10 min) |
OPEN SESSION
Session VII: Addressing Barriers to Research Translation in AD/ADRD
Session Objectives
- Examine the current landscape of targets and interventions in AD/ADRD prevention and treatment research.
- Explore methods to accelerate AD/ADRD research and to successfully translate research from discovery to application by learning from past successes and failures.
- Describe approaches that could aid the development of tools to support nonclinical and clinical research and to build capacity and buy-in for open science practices.
- Discuss strategies to enhance diversity, inclusion, and engagement in AD/ADRD prevention and treatment research.
| 11:05 a.m. |
Overview of Session Objectives
Rita Balice-Gordon, Committee Member, Moderator |
| 11:10 a.m. |
Opening Remarks
Jeffrey Cummings, University of Nevada, Las Vegas |
| 11:20 a.m. |
Panelist Remarks
Rema Raman, University of Southern California Charlotte Teunissen, Amsterdam University Medical Centers David Bennett, Rush University Michael Irizarry, Eisai Kristine Yaffe, University of California, San Francisco |
| 11:45 a.m. | Committee Discussion |
| 12:15 p.m. | Adjourn Public Session |
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
The Keck Center, 500 Fifth Street, NW
Washington, DC 20001
APRIL 24, 2024
Virtual
Session Objectives
- Discuss research gaps and priority areas related to sex and gender differences for Alzheimer’s disease and related dementias with the commissioned paper author.
- Provide input on edits to the draft commissioned paper materials.
| 12:30 p.m. |
Welcome and Review of Session Objectives
Tia Powell, Committee Chair |
| 12:35 p.m. |
Comments by the Commissioned Paper Author
Michelle Mielke, Wake Forest University |
| 1:50 p.m. | Committee Discussion |
| 2:15 p.m. | Adjourn Public Session |
COMMITTEE ON RESEARCH PRIORITIES FOR PREVENTING AND TREATING ALZHEIMER’S DISEASE AND RELATED DEMENTIAS
MAY 24, 2024
Virtual
Session Objectives
- Highlight recent discoveries and advances that have affected the state of the science for Lewy body dementia (LBD), frontotemporal dementia (FTD), vascular dementia, limbic-predominant age-related TDP-43 encephalopathy (LATE), and mixed etiology dementias.
- Identify priority research areas specific to these related dementias that, if addressed, could lead to significant advances in prevention and treatment.
| 12:00 p.m. |
Welcome and Review of Session Objectives
Tia Powell, Committee Chair |
| 12:10 p.m. |
Committee Discussion with Subject-Matter Experts
Julie Schneider, Rush University Penny Dacks, FTD Association James Galvin, University of Miami |
| 1:30 p.m. | Adjourn Public Session |
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